Patents by Inventor Ewa Witkowska

Ewa Witkowska has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hybrid peptidomimetics for use in neuropathic pain
    Patent number: 11041010
    Abstract: The invention pertains to novel hybrid peptidomimetics, pharmaceutical composition comprising thereof and use thereof in the treatment of neuropathic pain. The hybrid peptidomimetics according to the invention are comprised of two components: an opioid receptor agonist (OP) and a MC4 receptor antagonist, connected by a linker. The compounds of such a structure will allow to activate opioid receptors with simultaneous blocking of melanocortin type 4 receptors (MC4), which results in enhancing efficiency of the opioid therapy in neuropathic pain.
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: June 22, 2021
    Assignees: Uniwersytet Warszawski, Instytut Farmakologii Polskiej Akademii Nauk
    Inventors: Aleksandra Misicka-Kesik, Ewa Witkowska, Beata Wilenska, Barbara Przewlocka, Joanna Mika, Joanna Starnowska-Sokol, Anna Piotrowska-Murzyn
  • Cyclic peptidomimetics, compositions containing them and their use in the treatment of diseases associated with angiogenesis
    Patent number: 10800814
    Abstract: The present invention relates to novel cyclic peptidomimetics, pharmaceutical compositions containing them and their use in the treatment of diseases associated with angiogenesis especially tumors and chronic inflammation in psoriasis, diabetes, degenerative diseases of the eye (ARMD), nephropathy and neuropathy.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: October 13, 2020
    Assignee: UNIWERSYTET WARSZAWSKI
    Inventors: Aleksandra Misicka-Kesik, Karolina Grabowska, Anna Puszko, Anna Niescioruk, Piotr Sosnowski, Bartlomiej Fedorczyk, Dagmara Tymecka, Beata Wilenska, Ewa Witkowska
  • Novel Hybrid Peptidomimetics for Use in Neuropathic Pain
    Publication number: 20200207827
    Abstract: The invention pertains to novel hybrid peptidomimetics, pharmaceutical composition comprising thereof and use thereof in the treatment of neuropathic pain. The hybrid peptidomimetics according to the invention are comprised of two components: an opioid receptor agonist (OP) and a MC4 receptor antagonist, connected by a linker. The compounds of such a structure will allow to activate opioid receptors with simultaneous blocking of melanocortin type 4 receptors (MC4), which results in enhancing efficiency of the opioid therapy in neuropathic pain.
    Type: Application
    Filed: July 3, 2018
    Publication date: July 2, 2020
    Inventors: Aleksandra Misicka-Kesik, Ewa Witkowska, Beata Wilenska, Barbara Przewlocka, Joanna Mika, Joanna Starnowska-Sokol, Anna Piotrowska-Murzyn
  • Peptidomimetics with antiangiogenic activity
    Patent number: 10301352
    Abstract: We disclose novel peptidomimetics with antiangiogenic activity and their uses, particularly in the treatment of neoplasms and chronic inflammation (in particular of: rheumatoid arthritis, colitis), in eczema, diabetes, age-related macular degeneration (ARMD), nephropathy and neuropathy, in particular for use in the form of intravenous infusions or injections, or implants releasing the active ingredient.
    Type: Grant
    Filed: August 23, 2014
    Date of Patent: May 28, 2019
    Assignee: UNIWERSYTET WARSZAWSKI
    Inventors: Aleksandra Misicka-Kęsik, Dagmara Tymecka, Bartlomiej Fedorczyk, Piotr Sosnowski, Beata Wileńska, Ewa Witkowska, Patrick Ladam, Gerard Y. Perret, Anna Starzec
  • CYCLIC PEPTIDOMIMETICS, COMPOSITIONS CONTAINING THEM AND THEIR USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ANGIOGENESIS
    Publication number: 20180327455
    Abstract: The present invention relates to novel cyclic peptidomimetics, pharmaceutical compositions containing them and their use in the treatment of diseases associated with angiogenesis especially tumors and chronic inflammation in psoriasis, diabetes, degenerative diseases of the eye (ARMD), nephropathy and neuropathy.
    Type: Application
    Filed: August 29, 2016
    Publication date: November 15, 2018
    Inventors: Aleksandra MISICKA-KESIK, Karolina GRABOWSKA, Anna PUSZKO, Anna NIESCIORUK, Piotr SOSNOWSKI, Bartlomiej FEDORCZYK, Dagmara TYMECKA, Beata WILENSKA, Ewa WITKOWSKA
  • Novel Peptidomimetics With Antiangiogenic Activity
    Publication number: 20160333047
    Abstract: We disclose novel peptidomimetics with antiangiogenic activity and their uses, particularly in the treatment of neoplasms and chronic inflammation (in particular of: rheumatoid arthritis, colitis), in eczema, diabetes, age-related macular degeneration (ARMD), nephropathy and neuropathy, in particular for use in the form of intravenous infusions or injections, or implants releasing the active ingredient.
    Type: Application
    Filed: August 23, 2014
    Publication date: November 17, 2016
    Inventors: Aleksandra MISICKA-KESIK, Dagmara TYMECKA, Bartlomiej FEDORCZYK, Piotr SOSNOWSKI, Beata WILENSKA, Ewa WITKOWSKA, Patrick LADAM, Gerard Y. PERRET, Anna STARZEC
  • Analogs of human growth hormone-releasing hormone, their preparation and use
    Patent number: 7928063
    Abstract: Growth hormone-releasing hormone analogs having the amino acid sequence of the formula: Dat-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr10-R11-R12-VAL-Leu-Ala-Gln-Leu-Ser-Ala-R20-R21-Leu-Leu-Gln-Asp-Ile-Nle-Asp-R29-NH2 (I), wherein R11 is hArg, Gab or Gap; R12 is hArg, Orn, Gab or Gap; R20 is hArg, hArg, Gab or Gap; R21 is hArg, Orn, Gab or Gap; R29 is D-Arg, hArg, Gab or Gap; and their pharmaceutically acceptable salts. Said peptides are potent and selective stimulators of GH release and they are highly resistant to enzymatic degradation.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: April 19, 2011
    Assignees: Instytut Farmaceutyczny, Zaklady Farmaceutyczne Polpharma
    Inventors: Jan Izdebski, Danuta Kunce, Alicja Orlowska, Ewa Witkowska, Wieslaw Szelejewski, Andrzej Kutner, Krzysztof Bankowski, Elzbieta Frackiewicz
  • Analogs of human growth hormone-releasing hormone, their preparation and use
    Publication number: 20060172927
    Abstract: Growth hormone-releasing hormone analogs having the amino acid sequence of the formula: Dat-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr10-R11-R12-VAL-Leu-Ala-Gln-Leu-Ser-Ala-R20-R2-Leu-Leu-Gln-Asp-Ile-Nle-Asp-R29-NH2 (I), wherein R11 is hArg, Gab or Gap; R12 is hArg, Orn, Gab or Gap; R20 is hArg, hArg, Gab or Gap; R21 is hArg, Orn, Gab or Gap; R29 is D-Arg, hArg, Gab or Gap; and their pharmaceutically acceptable salts. Said peptides are potent and selective stimulators of GH release and they are highly resistant to enzymatic degradation.
    Type: Application
    Filed: October 30, 2002
    Publication date: August 3, 2006
    Inventors: Jan Izdebski, Danuta Kunce, Alicja Orlowska, Ewa Witkowska, Wieslaw Szelejewski, Andrzej Kutner, Krzysztof Bankowski, Elzbieta Frackiewicz