Patents by Inventor Ewan McIntosh Clark

Ewan McIntosh Clark has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combinations of proteasome inhibitors and cyclic peptides
    Patent number: 10328116
    Abstract: The present invention relates to a combination comprising a proteasome inhibitor and a cyclic peptide that comprises an exposed Arg-Gly-Asp (RGD) moiety. In particular, the present invention relates to a combination comprising a proteasome inhibitor selected from the group consisting of: a boronate, an epoxyketone, a peptide aldehyde and a ?-lactone protease inhibitor; and a cyclic peptide that comprises an exposed Arg-Gly-Asp (RGD) moiety. More particularly, the present invention relates to a combination comprising a proteasome inhibitor selected from the group consisting of: bortezomib, delanzomib, ixazomib, carfilzomib, oprozomib, MG132 and marizomib; and a cyclic peptide that comprises an exposed Arg-Gly-Asp (RGD) moiety.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: June 25, 2019
    Assignee: BIG DNA LTD
    Inventors: John Bernard March, Ewan McIntosh Clark
  • Combination Therapy
    Publication number: 20190175687
    Abstract: The present invention relates to a combination comprising a proteasome inhibitor and a cyclic peptide that comprises an exposed Arg-Gly-Asp (RGD) moiety. In particular, the present invention relates to a combination comprising a proteasome inhibitor selected from the group consisting of: a boronate, an epoxyketone, a peptide aldehyde and a ?-lactone protease inhibitor; and a cyclic peptide that comprises an exposed Arg-Gly-Asp (RGD) moiety. More particularly, the present invention relates to a combination comprising a proteasome inhibitor selected from the group consisting of: bortezomib, delanzomib, ixazomib, carfilzomib, oprozomib, MG132 and marizomib; and a cyclic peptide that comprises an exposed Arg-Gly-Asp (RGD) moiety.
    Type: Application
    Filed: November 13, 2018
    Publication date: June 13, 2019
    Inventors: John BERNARD March, Ewan McIntosh Clark
  • COMBINATION THERAPY
    Publication number: 20190134148
    Abstract: The present invention relates to a combination comprising a proteasome inhibitor and a cyclic peptide that comprises an exposed Arg-Gly-Asp (RGD) moiety; wherein the combination is formulated for oral administration of both the proteasome inhibitor and cyclic peptide components. In particular, the present invention relates to a combination comprising a proteasome inhibitor selected from the group consisting of: a boronate, anepoxyketone, a peptide aldehyde and a ?-lactone protease inhibitor; and a cyclic peptide that comprises an exposed Arg-Gly-Asp (RGD) moiety; wherein the combination is formulated for oral administration of both the proteasome inhibitor and cyclic peptide components.
    Type: Application
    Filed: April 25, 2017
    Publication date: May 9, 2019
    Inventors: John Bernard MARCH, Ewan McIntosh CLARK
  • Combinations of proteasome inhibitors and cyclic peptides
    Patent number: 10166269
    Abstract: The present invention relates to a combination comprising a proteasome inhibitor and a cyclic peptide that comprises an exposed Arg-Gly-Asp (RGD) moiety. In particular, the present invention relates to a combination comprising a proteasome inhibitor selected from the group consisting of: a boronate, an epoxyketone, a peptide aldehyde and a ?-lactone protease inhibitor; and a cyclic peptide that comprises an exposed Arg-Gly-Asp (RGD) moiety. More particularly, the present invention relates to a combination comprising a proteasome inhibitor selected from the group consisting of: bortezomib, delanzomib, ixazomib, carfilzomib, oprozomib, MG132 and marizomib; and a cyclic peptide that comprises an exposed Arg-Gly-Asp (RGD) moiety.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: January 1, 2019
    Assignee: BIG DNA LTD
    Inventors: John Bernard March, Ewan McIntosh Clark