Patents by Inventor EWART GRANT

EWART GRANT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for making opioids including 14-hydroxycodeinone and 14-hydroxymorphinone
    Patent number: 10649669
    Abstract: Improved processes for making opioid products having low impurity levels including making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.
    Type: Grant
    Filed: June 17, 2019
    Date of Patent: May 12, 2020
    Assignee: Johson Matthey Public Limited Company
    Inventors: Saroop Matharu, Brian Heinrich, Ewart Grant, Hongzhi Zhang
  • Processes for Making Opioids Including 14-Hydroxycodeinone and 14-Hydroxymorphinone
    Publication number: 20190310778
    Abstract: Improved processes for making opioid products having low impurity levels including making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.
    Type: Application
    Filed: June 17, 2019
    Publication date: October 10, 2019
    Inventors: Saroop MATHARU, Brian HEINRICH, Ewart GRANT, Hongzhi ZHANG
  • Process for the Preparation of Oxymorphone Alkaloid and Oxymorphone Salts
    Publication number: 20190225622
    Abstract: The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40° C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6?-oxymorphol produced is ?3.00 area % as determined by HPLC.
    Type: Application
    Filed: March 25, 2019
    Publication date: July 25, 2019
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Ewart GRANT, Brian HEINRICH, Saroop MATHARU, Nicholas ARCHER
  • Processes for Making Opioids Including 14-Hydroxycodeinone and 14-Hydroxymorphinone
    Publication number: 20190187914
    Abstract: Improved processes for making opioid products having low impurity levels including making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.
    Type: Application
    Filed: December 19, 2017
    Publication date: June 20, 2019
    Inventors: Saroop MATHARU, Brian HEINRICH, Ewart GRANT, Hongzhi ZHANG
  • Processes for making opioids including 14-hydroxycodeinone and 14-hydroxymorphinone
    Patent number: 10324632
    Abstract: Improved processes for making opioid products having low impurity levels including making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: June 18, 2019
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Saroop Matharu, Brian Heinrich, Ewart Grant, Hongzhi Zhang
  • Processes for Making Opioids Including 14-Hydroxycodeinone and 14-Hydroxymorphinone
    Publication number: 20180107407
    Abstract: Improved processes for making opioid products having low impurity levels including making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.
    Type: Application
    Filed: December 19, 2017
    Publication date: April 19, 2018
    Inventors: Saroop MATHARU, Brian HEINRICH, Ewart GRANT, Hongzhi ZHANG
  • Processes for making hydrocodone, hydromorphone and their derivatives
    Patent number: 9657027
    Abstract: Improved processes for making hydrocodone and hydromorphone as well as their 8,14-dihydrothebaine and 8,14-dihydrooripavine derivatives and salts are disclosed.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: May 23, 2017
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh Matharu, Ewart Grant, Brian W. Heinrich
  • Processes for making hydrocodone, hydromorphone and their derivatives
    Patent number: 9657028
    Abstract: Improved processes for making hydrocodone and hydromorphone as well as their 8,14-dihydrothebaine and 8,14-dihydrooripavine derivatives and salts are disclosed.
    Type: Grant
    Filed: January 22, 2016
    Date of Patent: May 23, 2017
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh Matharu, Ewart Grant, Brian W. Heinrich
  • PROCESSES FOR MAKING HYDROCODONE, HYDROMORPHONE AND THEIR DERIVATIVES
    Publication number: 20160137656
    Abstract: Improved processes for making hydrocodone and hydromorphone as well as their 8,14-dihydrothebaine and 8,14-dihydrooripavine derivatives and salts are disclosed.
    Type: Application
    Filed: January 22, 2016
    Publication date: May 19, 2016
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh MATHARU, Ewart GRANT, Brian W. HEINRICH
  • PROCESSES FOR MAKING HYDROCODONE, HYDROMORPHONE AND THEIR DERIVATIVES
    Publication number: 20160137655
    Abstract: Improved processes for making hydrocodone and hydromorphone as well as their 8,14-dihydrothebaine and 8,14-dihydrooripavine derivatives and salts are disclosed.
    Type: Application
    Filed: January 22, 2016
    Publication date: May 19, 2016
    Applicant: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh MATHARU, Ewart GRANT, Brian W. HEINRICH
  • Processes for making hydrocodone, hydromorphone and their derivatives
    Patent number: 9273060
    Abstract: Improved processes for making hydrocodone and hydromorphone as well as their 8,14-dihydrothebaine and 8,14-dihydrooripavine derivatives and salts are disclosed.
    Type: Grant
    Filed: March 5, 2014
    Date of Patent: March 1, 2016
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Saroop Singh Matharu, Ewart Grant, Brian W. Heinrich
  • Processes for Making Opioids Including 14-Hydroxycodeinone and 14-hydroxymorphinone
    Publication number: 20160052932
    Abstract: Improved processes for making opioid products having low impurity levels including making 14-hydroxycodeinone and 14-hydroxymorphinone from thebaine and oripavine, respectively.
    Type: Application
    Filed: August 25, 2014
    Publication date: February 25, 2016
    Inventors: Saroop Singh MATHARU, Brian W. HEINRICH, Ewart GRANT, Hongzhi ZHANG
  • Process for the preparation of oxymorphone alkaloid and oxymorphone salts
    Publication number: 20150329553
    Abstract: The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40° C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6?-oxymorphol produced is ?3.00 area % as determined by HPLC.
    Type: Application
    Filed: July 28, 2015
    Publication date: November 19, 2015
    Inventors: EWART GRANT, BRIAN HEINRICH, SAROOP MATHARU, NICOLAS ARCHER
  • PROCESSES FOR MAKING HYDROCODONE, HYDROMORPHONE AND THEIR DERIVATIVES
    Publication number: 20150252052
    Abstract: Improved processes for making hydrocodone and hydromorphone as well as their 8,14-dihydrothebaine and 8,14-dihydrooripavine derivatives and salts are disclosed.
    Type: Application
    Filed: March 5, 2014
    Publication date: September 10, 2015
    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
    Inventors: Saroop Singh MATHARU, Ewart GRANT, Brian W. HEINRICH
  • Process for the preparation of oxymorphone alkaloid and oxymorphone salts
    Patent number: 9120800
    Abstract: The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40° C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6?-oxymorphol produced is ?3.00 area % as determined by HPLC.
    Type: Grant
    Filed: February 5, 2014
    Date of Patent: September 1, 2015
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Ewart Grant, Brian Heinrich, Saroop Matharu, Nicolas Archer
  • PROCESS
    Publication number: 20150038715
    Abstract: The present invention provides a process for preparing an oxymorphone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxymorphinone and an acid to form a solution of the oxymorphone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than 40° C. in the presence of a hydrogenation catalyst and hydrogen gas, wherein the level of 6?-oxymorphol produced is ?3.00 area % as determined by HPLC.
    Type: Application
    Filed: February 5, 2014
    Publication date: February 5, 2015
    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
    Inventors: EWART GRANT, BRIAN HEINRICH, SAROOP MATHARU, NICOLAS ARCHER
  • Process
    Patent number: 8916707
    Abstract: The present invention provides a process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6?-oxycodol in an amount ?about 0.800 area % as determined by HPLC.
    Type: Grant
    Filed: August 2, 2013
    Date of Patent: December 23, 2014
    Assignee: Johnson Matthey Public Limited Company
    Inventors: Nicolas Archer, Maureen Young, Timothy Davies, Amy Price, Michael Bease, Barbara Jamieson, Ewart Grant, Brian Heinrich, Saroop Matharu
  • PROCESS
    Publication number: 20140045876
    Abstract: The present invention provides a process for preparing an oxycodone acid adduct, said process comprising hydrogenating an aqueous solution of 14-hydroxycodeinone and an acid to form a solution of the oxycodone acid adduct, wherein the hydrogenation is carried out at one or more temperatures greater than ambient temperature in the presence of a hydrogenation catalyst and hydrogen gas, wherein the solution of oxycodone acid adduct comprises 6?-oxycodol in an amount ?about 0.800 area % as determined by HPLC.
    Type: Application
    Filed: August 2, 2013
    Publication date: February 13, 2014
    Applicant: JOHNSON MATTHEY PUBLIC LIMITED COMPANY
    Inventors: NICOLAS ARCHER, MAUREEN YOUNG, TIMOTHY DAVIES, AMY PRICE, MICHAEL BEASE, BARBARA JAMIESON, EWART GRANT, BRIAN HEINRICH, SAROOP MATHARU