Patents by Inventor Ewen Kirkness

Ewen Kirkness has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GABAalpha receptor epsilon subunits
    Publication number: 20060148036
    Abstract: The present invention relates to a novel GABAA receptor ? subunit (GABRE) and an alternative transcript thereof (ET2). More specifically, isolated nucleic acid molecules are provided encoding human GABRE and ET2 receptor subunits. ET2 and GABRE polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of ET2 and GABRE activities. Also provided are diagnostic methods for detecting aberrant GABRE and ET2 expression, as well as therapeutic methods for treating disorders involving ET2 and GABRE.
    Type: Application
    Filed: February 3, 2006
    Publication date: July 6, 2006
    Applicant: Human Genome Sciences, Inc.
    Inventors: Michael Hanna, Ewen Kirkness
  • Human osteoclast derived cathepsin
    Publication number: 20060024299
    Abstract: Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
    Type: Application
    Filed: July 21, 2005
    Publication date: February 2, 2006
    Applicants: Human Genome Sciences, Inc., SmithKline Beecham Corp.
    Inventors: Gregg Hastings, Mark Adams, Claire Fraser, Norman Lee, Ewen Kirkness, Judith Blake, Lisa Fitzgerald, Fred Drake, Maxine Gowan
  • Human osteoclast derived cathepsin
    Publication number: 20050019889
    Abstract: Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases.
    Type: Application
    Filed: December 4, 2003
    Publication date: January 27, 2005
    Applicants: Human Genome Sciences, Inc., SmithKline Beecham Corporation
    Inventors: Gregg Hastings, Mark Adams, Claire Fraser, Norman Lee, Ewen Kirkness, Judith Blake, Lisa Fitzgerald, Fred Drake, Maxine Gowan
  • Polynucleotides encoding haemopoietic maturation factor
    Patent number: 5922572
    Abstract: Disclosed is a human maturation factor polypeptide and DNA(RNA) encoding such haemopoietic maturation factor polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques and antibodies against such polypeptide. Such polypeptides may be combined with a suitable pharmaceutical carrier or diluent to provide diagnostic, therapeutic and/or prophylactic effects against various diseases related to the underexpression of such human haemopoietic maturation factor polypeptide.
    Type: Grant
    Filed: January 25, 1994
    Date of Patent: July 13, 1999
    Assignee: Human Genome Sciences, Inc.
    Inventors: Craig A. Rosen, Henrik Olsen, Mark D. Adams, Ewen Kirkness