Patents by Inventor Eyal Breitbart

Eyal Breitbart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210095044
    Abstract: Disclosed herein are methods of treating, reducing the incidence of, or preventing one or more activities in or of a cancer cell, methods of treating, reducing the incidence of, or preventing migration or metastasis of a cancer cell, methods of treating, reducing the incidence of, or preventing a cancer by reducing tumor associated macrophages (TAMs) or their migration, and methods of treating, reducing the incidence of, or preventing a cancer (including metastatic cancer), for example, with an inhibitor of Motile Sperm Domain containing Protein 2 (MOSPD2). Also disclosed are inhibitors of MOSPD2 (e.g., anti-MOSPD2 antibodies or antigen binding fragments thereof) and pharmaceutical compositions containing MOSPD2 inhibitors. Also disclosed are methods for the prediction, diagnosis, or prognosis of cancer, cancer metastasis, tumor progression, or tumor invasiveness in a subject.
    Type: Application
    Filed: October 13, 2020
    Publication date: April 1, 2021
    Inventors: ITZHAK MENDEL, Oshrat PROPHETA-MEIRAN, Yaniv SALEM, Anat SHOHAM, Niva YACOV, Eyal BREITBART
  • Publication number: 20210077622
    Abstract: Disclosed herein are methods of treating, preventing, or reducing the incidence of an inflammatory disease or disorder and methods of inhibiting, preventing, or reducing the incidence of one or more activities in a cell with an inhibitor of a Motile Sperm Domain containing Protein 2 (MOSPD2). Also disclosed are inhibitors of MOSPD2 and pharmaceutical compositions containing MOSPD2 inhibitors.
    Type: Application
    Filed: September 14, 2020
    Publication date: March 18, 2021
    Inventors: ITZHAK MENDEL, Oshrat Propheta-Meiran, Yaniv Salem, Anat Shoham, Eyal Breitbart
  • Publication number: 20200407434
    Abstract: Disclosed herein are bispecific antibodies or antigen binding fragments thereof that specifically bind to Motile Sperm Domain Containing Protein 2 (MOSPD2) and to a T cell-specific or NK cell-specific receptor molecule, pharmaceutical compositions and kits containing the same, and methods of making and using the same.
    Type: Application
    Filed: March 13, 2019
    Publication date: December 31, 2020
    Inventors: Itzhak MENDEL, Yaniv SALEM, Eyal BREITBART
  • Publication number: 20200046852
    Abstract: The invention provides methods of inducing or improving responsiveness to a VEGF antagonist to a subject or a subject population comprising administering an adenovirus comprising a nucleic acid construct comprising a F AS-chimera gene operably linked to an endothelial cell-specific promoter and administering the VEGF antagonist.
    Type: Application
    Filed: July 8, 2019
    Publication date: February 13, 2020
    Applicant: Vascular Biogenics Ltd.
    Inventors: Andrea Rachel LEUBITZ, Naamit SHER, Erez FEIGE, Eyal BREITBART
  • Patent number: 10464957
    Abstract: The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of making an oxidized lipid of the invention and to methods of treating or preventing fibrosis or inflammatory diseases or disorders comprising an oxidized lipid of the invention.
    Type: Grant
    Filed: August 16, 2017
    Date of Patent: November 5, 2019
    Assignee: VASCULAR BIOGENICS LTD.
    Inventors: Eti Kovalevski Ishai, Itzhak Mendel, Yaniv Salem, Niva Yacov, Eyal Breitbart
  • Patent number: 10383954
    Abstract: The invention provides methods of inducing or improving responsiveness to a VEGF antagonist to a subject or a subject population comprising administering an adenovirus comprising a nucleic acid construct comprising a F AS-chimera gene operably linked to an endothelial cell-specific promoter and administering the VEGF antagonist.
    Type: Grant
    Filed: May 26, 2017
    Date of Patent: August 20, 2019
    Assignee: Vascular Biogenics Ltd.
    Inventors: Andrea Rachel Leubitz, Naamit Sher, Erez Feige, Eyal Breitbart
  • Patent number: 10369196
    Abstract: Methods of treating a malignant glioma in a subject are disclosed. The methods comprise administering to the subject a therapeutically effective amount of a viral vector comprising: (i) a first polynucleotide sequence encoding a Fas-chimera (Fas-c), said first polynucleotide sequence comprising SEQ ID NOs: 2 and 3; and (ii) a second polynucleotide sequence encoding an endothelial cell-specific promoter or a periendothelial cell-specific promoter.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: August 6, 2019
    Assignee: Vascular Biogenics Ltd.
    Inventors: Yael Cohen, Livnat Bangio, Andrew J. Brenner, Eyal Breitbart
  • Publication number: 20190054130
    Abstract: The invention provides methods of reducing or decreasing a size of a tumor or eliminating a tumor by inhibiting, decreasing, or reducing neo-vascularization or angiogenesis in a tumor in a patient by administering an adenovirus comprising a nucleic acid construct comprising a FAS-chimera gene operably linked to an endothelial cell-specific promoter. Also provided is a homogeneous population of an adenovirus comprising a FAS-chimera gene operably linked to an endothelial cell-specific promoter and its uses thereof.
    Type: Application
    Filed: July 23, 2018
    Publication date: February 21, 2019
    Applicant: Vascular Biogenics Ltd.
    Inventors: Eyal Breitbart, Andrea Leubitz, Erez Feige, Richard Penson
  • Patent number: 10206936
    Abstract: The present invention is directed to methods of treating or preventing fibrosis comprising an oxidized lipid or pharmaceutical composition comprising the same.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: February 19, 2019
    Assignee: Vascular Biogenics Ltd.
    Inventors: Itzhak Mendel, Yaniv Salem, Niva Yacov, Eyal Breitbart
  • Publication number: 20190040150
    Abstract: Disclosed herein are methods of treating, reducing the incidence of, or preventing one or more activities in or of a cancer cell, methods of treating, reducing the incidence of, or preventing migration or metastasis of a cancer cell, methods of treating, reducing the incidence of, or preventing a cancer by reducing tumor associated macrophages (TAMs) or their migration, and methods of treating, reducing the incidence of, or preventing a cancer (including metastatic cancer), for example, with an inhibitor of Motile Sperm Domain containing Protein 2 (MOSPD2). Also disclosed are inhibitors of MOSPD2 (e.g., anti-MOSPD2 antibodies or antigen binding fragments thereof) and pharmaceutical compositions containing MOSPD2 inhibitors. Also disclosed are methods for the prediction, diagnosis, or prognosis of cancer, cancer metastasis, tumor progression, or tumor invasiveness in a subject.
    Type: Application
    Filed: July 29, 2016
    Publication date: February 7, 2019
    Inventors: Itzhak Mendel, Oshrat PROPHETA-MEIRAN, Yaniv SALEM, Anat SHOHAM, Niva YACOV, Eyal BREITBART
  • Publication number: 20180325928
    Abstract: The present invention is directed to methods of treating or preventing fibrosis comprising an oxidized lipid or pharmaceutical composition comprising the same.
    Type: Application
    Filed: July 16, 2018
    Publication date: November 15, 2018
    Inventors: Itzhak MENDEL, Yaniv SALEM, Niva YACOV, Eyal BREITBART
  • Publication number: 20180214543
    Abstract: Disclosed herein are methods of treating, preventing, or reducing the incidence of an inflammatory disease or disorder and methods of inhibiting, preventing, or reducing the incidence of one or more activities in a cell with an inhibitor of a Motile Sperm Domain containing Protein 2 (MOSPD2). Also disclosed are inhibitors of MOSPD2 and pharmaceutical compositions containing MOSPD2 inhibitors.
    Type: Application
    Filed: July 29, 2016
    Publication date: August 2, 2018
    Inventors: Itzhak Mendel, Oshrat PROPHETA-MEIRAN, Yaniv SALEM, Anat SHOHAM, Eyal BREITBART
  • Patent number: 10022388
    Abstract: The present invention is directed to methods of treating or preventing fibrosis comprising an oxidized lipid or pharmaceutical composition comprising the same.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: July 17, 2018
    Assignee: Vascular Biogenics Ltd.
    Inventors: Itzhak Mendel, Yaniv Salem, Niva Yacov, Eyal Breitbart
  • Publication number: 20170369516
    Abstract: The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of making an oxidized lipid of the invention and to methods of treating or preventing fibrosis or inflammatory diseases or disorders comprising an oxidized lipid of the invention.
    Type: Application
    Filed: August 16, 2017
    Publication date: December 28, 2017
    Inventors: Eti Kovalevski ISHAI, Itzhak MENDEL, Yaniv SALEM, Niva YACOV, Eyal BREITBART
  • Publication number: 20170354746
    Abstract: The invention provides methods of inducing or improving responsiveness to a VEGF antagonist to a subject or a subject population comprising administering an adenovirus comprising a nucleic acid construct comprising a F AS-chimera gene operably linked to an endothelial cell-specific promoter and administering the VEGF antagonist.
    Type: Application
    Filed: May 26, 2017
    Publication date: December 14, 2017
    Applicant: Vascular Biogenics Ltd.
    Inventors: Andrea Rachel LEUBITZ, Naamit Sher, Erez Feige, Eyal Breitbart
  • Patent number: 9771385
    Abstract: The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of making an oxidized lipid of the invention and to methods of treating or preventing fibrosis or inflammatory diseases or disorders comprising an oxidized lipid of the invention.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: September 26, 2017
    Assignee: Vascular Biogenics Ltd.
    Inventors: Eti Kovalevski Ishai, Itzhak Mendel, Yaniv Salem, Niva Yacov, Eyal Breitbart
  • Publication number: 20170258818
    Abstract: The present invention is directed to methods of treating or preventing fibrosis comprising an oxidized lipid or pharmaceutical composition comprising the same.
    Type: Application
    Filed: May 23, 2017
    Publication date: September 14, 2017
    Inventors: Itzhak Mendel, Yaniv Salem, Niva Yacov, Eyal Breitbart
  • Patent number: 9682154
    Abstract: The invention provides methods of inducing or improving responsiveness to a VEGF antagonist to a subject or a subject population comprising administering an adenovirus comprising a nucleic acid construct comprising a FAS-chimera gene operably linked to an endothelial cell-specific promoter and administering the VEGF antagonist.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: June 20, 2017
    Assignee: Vascular Biogenics Ltd.
    Inventors: Andrea Rachel Leubitz, Naamit Sher, Erez Feige, Eyal Breitbart
  • Patent number: 9567605
    Abstract: Anti-angiogenic adenovirus vectors, and therapeutic use thereof are provided, and more particularly, but not exclusively, clinical protocols for treatment of solid tumors in patients with an Ad5-PPE-1-3X-fas-chimera adenovirus vector.
    Type: Grant
    Filed: January 5, 2011
    Date of Patent: February 14, 2017
    Assignee: Vascular Biogenics Ltd.
    Inventors: Yael Cohen, Naamit Sher, Erez Feige, Livnat Bangio, Eyal Breitbart
  • Publication number: 20160304544
    Abstract: The present invention is directed to oxidized lipids and pharmaceutical compositions comprising the same. The present invention is also directed to methods of making an oxidized lipid of the invention and to methods of treating or preventing fibrosis or inflammatory diseases or disorders comprising an oxidized lipid of the invention.
    Type: Application
    Filed: November 25, 2015
    Publication date: October 20, 2016
    Inventors: Eti Kovalevski ISHAI, Itzhak Mendel, Yaniv Salem, Niva Yacov, Eyal Breitbart