Patents by Inventor Eyal Grunebaum

Eyal Grunebaum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ephrin and EPH receptor mediated immune modulation
    Publication number: 20070292904
    Abstract: Methods and compositions for immune modulation are described. The methods involve modulating an ephrin or Eph receptor which consequently modulates an immune response, in particular a T cell response, modulates immune adhesion cell, modulates chemotaxis and/or migration or modulates apoptosis. The method is useful in treating a variety of conditions, including autoimmune disease, allergy, graft versus host disease, transplant rejection and cancer.
    Type: Application
    Filed: February 8, 2007
    Publication date: December 20, 2007
    Applicant: The Hospital for Sick Children
    Inventors: Chaim Roifman, Andrew Freywald, Nigel Sharfe, Thomas Grunberger, Eyal Grunebaum
  • Methods of modulation of the immune system
    Publication number: 20070218070
    Abstract: Manipulation of the EphB6 receptor and its active Eph partners allow for regulation of T cell responses, including TCR signalling, T cell proliferation, and induction of T cell death. Methods of modulating EphB6 are described as well as various therapeutic applications.
    Type: Application
    Filed: March 2, 2007
    Publication date: September 20, 2007
    Applicant: The Hospital For Sick Children
    Inventors: Chaim Roifman, Andrew Freywald, Nigel Sharfe, Thomas Grunberger, Eyal Grunebaum
  • Ephrin and eph receptor mediated immune modulation
    Publication number: 20040247592
    Abstract: Methods and compositions for immune modulation are described. The methods involve modulating an ephrin or Eph receptor which consequently modulates an immune response, in particular a T cell response, modulates immune adhesion cell, modulates chemotaxis and/or migration and modulates apoptosis. The method is useful in treating a variety of conditions, including autoimmune disease, allergy, graft versus host disease, transplant rejection and cancer.
    Type: Application
    Filed: June 29, 2004
    Publication date: December 9, 2004
    Inventors: Chaim M. Roifman, Andrew Freywald, Nigel Sharfe, Thomas Grunberger, Eyal Grunebaum