Patents by Inventor Eyal Kalie

Eyal Kalie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant interferon ?2 (IFN?2) mutants and methods of use thereof
    Patent number: 7919078
    Abstract: The present invention provides IFN?2 mutants and active fragments, analogs, derivatives, and variants thereof, nucleotide molecules encoding same, pharmaceutical compositions containing the same, and methods utilizing the same for treating cancer, infectious diseases, and autoimmune diseases.
    Type: Grant
    Filed: January 4, 2008
    Date of Patent: April 5, 2011
    Assignee: Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Gideon E Schreiber, Laila C. Roisman, Diego Jaitin, Eyal Kalie
  • Nucleic acid molecules encoding recombinant interferon-?2 (IFN?2) mutants
    Patent number: 7767799
    Abstract: The present invention provides IFN?2 mutants and active fragments, analogs, derivatives, and variants thereof that have improved specific agonist or antagonist activity as compared to wild-type IFN?2. The present invention further provides pharmaceutical compositions comprising IFN?2 mutants useful for treating or preventing cancer, autoimmune diseases, infectious diseases or disorders associated with increased expression of IFN?2.
    Type: Grant
    Filed: June 28, 2006
    Date of Patent: August 3, 2010
    Assignee: Yeda Research and Development Co. Ltd. at the Weizmann Institute of Science
    Inventors: Gideon E Schreiber, Laila C. Roisman, Diego Jaitin, Eyal Kalie
  • Recombinant Interferon 2alpha (Infalpha2) Mutants
    Publication number: 20080279823
    Abstract: The present invention provides IFN?2 mutants and active fragments, analogs, derivatives, and variants thereof that have improved specific agonist or antagonist activity as compared to wild-type IFN?2. The present invention further provides pharmaceutical compositions comprising IFN?2 mutants useful for treating or preventing cancer, autoimmune diseases, infectious diseases or disorders associated with increased expression of IFN?2.
    Type: Application
    Filed: June 28, 2006
    Publication date: November 13, 2008
    Inventors: Gideon E. Schreiber, Laila C. Roisman, Diego Jaitin, Eyal Kalie
  • RECOMBINANT INTERFERON ALPHA2 (IFNALPHA2) MUTANTS AND METHODS OF USE THEREOF
    Publication number: 20080166319
    Abstract: The present invention provides IFN?2 mutants and active fragments, analogs, derivatives, and variants thereof, nucleotide molecules encoding same, pharmaceutical compositions containing the same, and methods utilizing the same for treating cancer, infectious diseases, and autoimmune diseases.
    Type: Application
    Filed: January 4, 2008
    Publication date: July 10, 2008
    Inventors: Gideon E Schreiber, Laila C. Roisman, Diego Jaitin, Eyal Kalie