Abstract: Various approaches to generating and maintaining an ultrasound focus at a target region include configuring a controller to cause transmission of treatment ultrasound pulses from a transducer having multiple transducer elements; cause the transducer to transmit focusing ultrasound pulses to the target region and generate an acoustic reflector therein; measure reflections of the focusing ultrasound pulses from the acoustic reflector; based at least in part on the measured reflections, adjust a parameter value associated with one or more transducer elements so as to maintain and/or improve the ultrasound focus at the target region.

Abstract: In ultrasound therapy, the frequency of sonications can be optimized, within a certain frequency range, to maximize the absorption or the acoustic intensity at the target in a manner specific to the patient.

Abstract: Various approaches for heating a target region substantially uniformly include identifying one or more locations of one or more hot spots in the target region and/or surrounding regions of the target region during an ultrasound sonication process; computing a temporal variation to an output parameter of at least one of the transducer elements based at least in part on the identified location(s) of the hot spot(s); and operating the at least one transducer element to achieve the temporal variation of the output parameter so as to minimize the hot spot(s).

Abstract: Embodiments of the present invention provide systems and methods to verify and/or obtain a registration of images obtained two image systems (such as a CT system and an MRI system) via the use of a third imaging modality (such as an ultrasound system).

Abstract: Various approaches for reducing microbubble interference with ultrasound waves transmitted from multiple transducer elements and traversing tissue onto a target region include measuring microbubbles in high-throughput areas of ultrasound exposure and reducing the amount of microbubbles using the ultrasound waves.

Abstract: Embodiments of the present invention provide systems and methods to detect a moving anatomic feature during a treatment sequence based on a computed and/or a measured shortest distance between the anatomic feature and at least a portion of an imaging system.

Abstract: Embodiments of the present invention provide systems and methods to verify and/or obtain a registration of images obtained two image systems (such as a CT system and an MRI system) via the use of a third imaging modality (such as an ultrasound system).

Abstract: Skull inhomogeneity may be quantified in accordance with the skull density measured in skull images acquired using a conventional imager; the quantified inhomogeneity may then be used to determine whether the patient is suitable for ultrasound treatment and/or determine parameters associated with the ultrasound transducer for optimizing transskull ultrasound treatment.

Abstract: In ultrasound therapy, the frequency of sonications can be optimized, within a certain frequency range, to maximize the absorption or the acoustic intensity at the target in a manner specific to the patient.

Abstract: The present invention provides procedures and systems that use a closed-loop approach for directing ultrasound energy at a clot while monitoring blood flow and/or liquification of the clot tissue so as to allow automated and/or manual adjustments to various treatment parameters.

Abstract: Treatment of moving tissue may be facilitated by identifying voxels within a volume of the tissue, associating treatment-related attributes with the voxels, and shifting positions of the voxels based on the tissue movement. One or more treatment parameters may then be altered based on the treatment-related attributes of the shifted voxels.

Abstract: Ultrasound energy is delivered to a patient in a controlled manner using a focused ultrasound system, thus maintaining the desired therapeutic effect without causing unwanted damage to surrounding tissue. An ultrasound transducer device includes multiple transducer elements, each of which is controlled by drive circuitry and a drive signal controller. An acoustic detector detects signals indicative of cavitation in tissue targeted by the transducer elements, and the drive signal controller manages the delivery of acoustic energy from the transducer elements based on the detected cavitation signals such that a therapeutic effect at the target tissue remains within an efficacy range.

Abstract: The emission intensities of transducer elements of an ultrasound transducer array are controlled based on anatomical characteristics of non-uniform tissue regions, e.g., regions of a skull, and a pre-determined threshold.

Abstract: The present invention provides procedures and systems that use a closed-loop approach for directing ultrasound energy at a clot while monitoring blood flow and/or liquification of the clot tissue so as to allow automated and/or manual adjustments to various treatment parameters.