Patents by Inventor Eyal Zussman
Eyal Zussman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170002481Abstract: A method of attaching a molecule-of-interest to a microtube, by co-electrospinning two polymeric solutions through co-axial capillaries, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution and the second polymeric solution comprises the molecule-of-interest, thereby attaching the molecule-of-interest to the microtube. An electrospun microtube comprising an electrospun shell, an electrospun coat over an internal surface of the shell and a molecule-of-interest attached to the microtube.Type: ApplicationFiled: September 1, 2016Publication date: January 5, 2017Inventors: Eyal ZUSSMAN, Yael DROR, Jonathan Charles KUHN
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Patent number: 9469919Abstract: A method of attaching a cell or a membrane-coated particle-of-interest to a microtube is provided. The method comprising: co-electrospinning two polymeric solutions through co-axial capillaries, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution and wherein the second polymeric solution comprises the cell or the membrane-coated particle-of-interest, thereby attaching the cell or the membrane-coated panicle-of-interest to the microtube. Also provided are microtubes with attached, entrapped or encapsulated cells or membrane-coated particles and methods of using same.Type: GrantFiled: February 12, 2009Date of Patent: October 18, 2016Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Jonathan Charles Kuhn, Eyal Zussman, Michal Green, Shiri Klein
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Patent number: 9464368Abstract: Provided is a method of attaching a molecule-of-interest to a microtube, by co-electrospinning two polymeric solutions through co-axial capillaries, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution and wherein the second polymeric solution comprises the molecule-of-interest, thereby attaching the molecule-of-interest to the microtube. Also provided is an electrospun microtube comprising an electrospun shell, an electrospun coat over an internal surface of the shell and a molecule-of-interest attached to the microtube.Type: GrantFiled: February 12, 2009Date of Patent: October 11, 2016Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Eyal Zussman, Yael Dror, Jonathan Charles Kuhn
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Patent number: 9297094Abstract: Provided is a method of delivering a medicament or a diagnostic agent to a subject in need thereof by (a) introducing a microtube configured to deliver the medicament or the diagnostic agent into the subject, said microtube comprises an electrospun shell and an electrospun coat over an internal surface of said shell, and (b) administering the medicament or the diagnostic agent through said microtube, thereby delivering the medicament or the diagnostic agent to the subject. Also provided are kits for delivering a medicament or a diagnostic agent.Type: GrantFiled: February 12, 2009Date of Patent: March 29, 2016Assignee: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventor: Eyal Zussman
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Publication number: 20160032271Abstract: A method of preserving organisms in viable form, the method comprising: suspending organisms in a solution of electrospinnable polymer; drawing droplets of said solution through a spinneret; applying an electrostatic field to said droplets under electrospinning conditions; so as to form fibers having a diameter no greater than about 5 ?m within which distinct organisms are encapsulated in viable form.Type: ApplicationFiled: August 4, 2015Publication date: February 4, 2016Applicant: Technion Research & Development Foundation LimitedInventors: Jonathan Charles KUHN, Eyal ZUSSMAN
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Patent number: 9144585Abstract: Provided are methods of isolating an extracellular matrix from mesenchymal progenitor cells which are characterized by a reduced differentiation ability into an adipogenic lineage as compared to adipose-derived mesenchymal stem cells. Also provide isolated extracellular matrix and hybrid devices comprising electrospun elements and extracellular matrix which can be used for various tissue regeneration, repair and reconstruction surgeries.Type: GrantFiled: July 27, 2011Date of Patent: September 29, 2015Assignee: Technion Research & Development Foundation LimitedInventors: Joseph Itskovitz-Eldor, Ronit Shtrichman, Eyal Zussman, Efrat Barak
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Patent number: 9096845Abstract: A method of preserving organisms in viable form, the method comprising: suspending organisms in a solution of electrospinnable polymer; drawing droplets of said solution through a spinneret; applying an electrostatic field to said droplets under electrospinning conditions; so as to form fibers having a diameter no greater than about 5 ?m within which distinct organisms are encapsulated in viable form.Type: GrantFiled: August 29, 2007Date of Patent: August 4, 2015Assignee: Technion Research & Development Foundation LimitedInventors: Jonathan Charles Kuhn, Eyal Zussman
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Publication number: 20150183661Abstract: Provided are methods of petroleum sequestration, which use electrospun microtubes capable of sequestering the petroleum from the water, and method of depleting and optionally degrading petroleum from water using floating devices which comprise the electrospun microtube attached to a floating carrier.Type: ApplicationFiled: July 3, 2013Publication date: July 2, 2015Inventors: Ohad Ben Dror, Eyal Zussman, Yael Dror
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Publication number: 20150105863Abstract: A fiber-reinforced hydrogel composite is provided. The composite includes a hydrogel and a fibrous component containing a plurality of fibers. Length of each of the plurality of fibers is less than about 1,000 ?m. A method of preparing a fiber-reinforced hydrogel composite is also provided. The method includes coating a hydrogel precursor solution on a substrate to form a hydrogel precursor film, depositing the plurality of fibers onto the hydrogel precursor film, and allowing the hydrogel precursor film to form a hydrogel film, (ii) thereby forming the fiber-reinforced hydrogel composite. A scaffold containing the fiber-reinforced composite, and a tissue repair method (iii) using the fiber-reinforced composite are also provided.Type: ApplicationFiled: May 15, 2013Publication date: April 16, 2015Applicant: National University of SingaporeInventors: Eyal Zussman, Srinivasa Reddy Chaganti, Jayarama Reddy Venugopal, Seeram Ramakrishna, Omri Regev
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Patent number: 8911996Abstract: A porous scaffold is disclosed, the porous scaffold comprising electrospun polymeric nanofibers, wherein an average diameter of a pore of the porous scaffold is about 300 ?m is disclosed. An average diameter of the polymeric nanofibers ranges from about 100 to 400 nm. The scaffold may comprise a plurality of particles, the particles being greater than about 1 ?m in diameter. Methods of fabricating scaffolds, methods for generating tissue and methods of using scaffolds for tissue reconstruction are also disclosed.Type: GrantFiled: January 31, 2008Date of Patent: December 16, 2014Assignee: Technion Research & Development Foundation LimitedInventors: Samer Srouji, Eyal Zussman, Erella Livne
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Patent number: 8871237Abstract: Articles of manufacturing comprising electrospun elements having continuous or stepwise gradients of porosity, average pore size, weight per volume and/or of agents for promoting cell colonization, differentiation, extravasation and/or migration are provided. Also provided are methods of manufacturing and using same for guiding tissue regeneration.Type: GrantFiled: April 4, 2006Date of Patent: October 28, 2014Assignee: Technion Research & Development Foundation LimitedInventors: Eyal Zussman, Erella Livne, Samer Srouji, Shmuel Chervinsky
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Publication number: 20140010850Abstract: Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue.Type: ApplicationFiled: September 16, 2013Publication date: January 9, 2014Applicant: Technion Research & Development Foundation LimitedInventors: Eyal ZUSSMAN, David Simhon, Shmuel Chervinsky, Abraham Katzir, Zvi Nevo, Yael Dror
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Patent number: 8551948Abstract: Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue.Type: GrantFiled: March 28, 2013Date of Patent: October 8, 2013Assignee: Technion Research & Development Foundation LimitedInventors: Eyal Zussman, David Simhon, Shmuel Chervinsky, Abraham Katzir, Zvi Nevo, Yael Dror
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Patent number: 8546333Abstract: Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue.Type: GrantFiled: January 31, 2008Date of Patent: October 1, 2013Assignee: Technion Research & Development Foundation LimitedInventors: Eyal Zussman, David Simhon, Shmuel Chervinsky, Abraham Katzir, Zvi Nevo, Yael Dror
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Publication number: 20130230601Abstract: Provided are methods of isolating an extracellular matrix from mesenchymal progenitor cells which are characterized by a reduced differentiation ability into an adipogenic lineage as compared to adipose-derived mesenchymal stem cells. Also provide isolated extracellular matrix and hybrid devices comprising electrospun elements and extracellular matrix which can be used for various tissue regeneration, repair and reconstruction surgeries.Type: ApplicationFiled: July 27, 2011Publication date: September 5, 2013Applicant: Technion Research & Development Foundation Ltd.Inventors: Joseph Itskovitz-Eldor, Ronit Shtrichman, Eyal Zussman, Efrat Barak
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Publication number: 20130030452Abstract: Provided is a device comprising at least two layers, said at least two layers being at least partially overlapping (e.g., superposed) and contacting one another, wherein a first layer of said at least two layers comprises a non-biodegradable mesh, and wherein a second layer of the at least two layers comprises an electrospun element, and wherein the device is devoid of an extracellular matrix generated by mesenchymal progenitor cells, which are characterized by a reduced differentiation potential into an adipogenic lineage by at least about 50% as compared to differentiation potential of mesenchymal stem cells from an adult adipose source under identical assay conditions, and by an increased osteogenic differentiation potential by at least about 20% as compared to the osteogenic differentiation potential of adipose-derived MSCs under identical assays conditions.Type: ApplicationFiled: July 26, 2012Publication date: January 31, 2013Applicants: Health Corporation - Rambam, Technion Research & Development Foundation Ltd.Inventors: Joseph ITSKOVITZ-ELDOR, Eyal Zussman, Lior Lowenstein, Naama Zeevi-Levin, Liron Eldor
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Publication number: 20110230411Abstract: Provided are method of generating a fiber from a globular protein such as albumin. Also provided are albumin fibers and fabrics and methods of using same for bonding a damaged tissue or for ex vivo or in vivo formation of a tissue.Type: ApplicationFiled: January 31, 2008Publication date: September 22, 2011Applicant: ZVI NEVOInventors: Eyal Zussman, David Simhon, Shmuel Chervinsky, Abraham Katzir, Zvi Nevo, Yael Dror
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Publication number: 20110081394Abstract: Provided is a method of attaching a molecule-of-interest to a microtube, by co-electrospinning two polymeric solutions through co-axial capillaries, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution and wherein the second polymeric solution comprises the molecule-of-interest, thereby attaching the molecule-of-interest to the microtube. Also provided is an electrospun microtube comprising an electrospun shell, an electrospun coat over an internal surface of the shell and a molecule-of-interest attached to the microtube.Type: ApplicationFiled: February 12, 2009Publication date: April 7, 2011Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Eyal Zussman, Yael Dror, Jonathan Charles Kuhn
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Publication number: 20110082565Abstract: A method for fabricating a nonwoven structure is disclosed. The method comprises: forming a nonwoven layer of polymer fibers on the collector liquid surface, transferring the layer to a solid surface, and repeating the formation and the transfer in a layerwise manner. The method is generally effected by spinning liquefied polymer, in particular by employing electrostatic or hydrostatic forces. The nonwoven structure formed comprises of plurality of nonwoven layers: the average thickness of the nonwoven structure is at least 0.5 mm and the structure has an overall porosity of at least 90%. The nonwoven structure an be used in forming a scaffold for tissue engineering, in particular a cell-scaffold composition, suitable for implanting in a patient, wherein at least one cell population is seeded on at least one of the plurality of layers.Type: ApplicationFiled: June 8, 2009Publication date: April 7, 2011Inventors: Roey Tzezana, Shulamit Levenberg, Eyal Zussman
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Publication number: 20110039296Abstract: A method of attaching a cell or a membrane-coated particle-of-interest to a microtube is provided. The method comprising: co-electrospinning two polymeric solutions through co-axial capillaries, wherein a first polymeric solution of the two polymeric solutions is for forming a shell of the microtube and a second polymeric solution of the two polymeric solutions is for forming a coat over an internal surface of the shell, the first polymeric solution is selected solidifying faster than the second polymeric solution and a solvent of the second polymeric solution is selected incapable of dissolving the first polymeric solution and wherein the second polymeric solution comprises the cell or the membrane-coated particle-of-interest, thereby attaching the cell or the membrane-coated panicle-of-interest to the microtube. Also provided are microtubes with attached, entrapped or encapsulated cells or membrane-coated particles and methods of using same.Type: ApplicationFiled: February 12, 2009Publication date: February 17, 2011Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LTD.Inventors: Jonathan Charles Kuhn, Eyal Zussman, Michal Green, Shiri Klein