Patents by Inventor Ez-Zoubir Amri

Ez-Zoubir Amri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Established human brown adipocyte line and method for differentiation from an hMADS cell line
    Patent number: 9790469
    Abstract: The subject matter of the invention is a functional population of human brown adipocytes, in which the expression of UCP1, CIDEA, CPT1B and Bc12 is higher, the expression of Bax is lower and the expression of PPAR-alpha, PGC-1alpha, PGC-1 beta and PRDM16 is similar compared with the corresponding expressions of a population of human white adipocytes. The invention also relates to a method for differentiation of hMADS cells into the functional population of human brown adipocytes, to a method for conversion of a population of human white adipocytes into the functional population of human brown adipocytes, and also to a method of screening for molecules capable of modulating the bodyweight in an individual.
    Type: Grant
    Filed: June 23, 2009
    Date of Patent: October 17, 2017
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE NICE SOPHIA-ANTIPOLIS
    Inventors: Gérard Paul Ailhaud, Ez-Zoubir Amri, Christian Jean Lucien Dani, Christian Elabd
  • UCP1 (THERMOGENIN) - INDUCING AGENTS FOR USE IN THE TREATMENT OF A DISORDER OF THE ENERGY HOMEOSTASIS
    Publication number: 20160298115
    Abstract: The present invention relates to compositions comprising an agent, like a polynucleotide, which induces or upregulates expression of UCP1 for use in treating or preventing a disorder of the energy homeostasis, overweight, adiposity, obesity, metabolic syndrome or related diseases or disorders in a subject. The present invention also relates to a method of treating or preventing a disorder of the energy homeostasis, overweight, adiposity, obesity, metabolic syndrome or related diseases or disorders in a subject comprising administrating a composition comprising a polynucleotide which induces or upregulates expression of UCP1.
    Type: Application
    Filed: March 22, 2016
    Publication date: October 13, 2016
    Applicants: Centre National de la Recherche Scientifique, l'Université Nice Sophia Antipolis
    Inventors: Marcel SCHEIDELER, Michael KARBIENER, Ez-Zoubir AMRI, Gérard AILHAUD, Christian DANI
  • UCP1 (thermogenin)—inducing agents for use in the treatment of a disorder of the energy homeostasis
    Patent number: 9320756
    Abstract: The present invention relates to compositions comprising an agent, like a polynucleotide, which induces or upregulates expression of UCP1 for use in treating or preventing a disorder of the energy homeostasis, overweight, adiposity, obesity, metabolic syndrome or related diseases or disorders in a subject. The present invention also relates to a method of treating or preventing a disorder of the energy homeostasis, overweight, adiposity, obesity, metabolic syndrome or related diseases or disorders in a subject comprising administrating a composition comprising a polynucleotide which induces or upregulates expression of UCP1.
    Type: Grant
    Filed: May 6, 2011
    Date of Patent: April 26, 2016
    Assignees: Centre National de la Recherche Scientifique, l'Université Nice Sophia Antipolis
    Inventors: Marcel Scheideler, Michael Karbiener, Ez-Zoubir Amri, Gérard Ailhaud, Christian Dani
  • UCP1 (THERMOGENIN) - INDUCING AGENTS FOR USE IN THE TREATMENT OF A DISORDER OF THE ENERGY HOMEOSTASIS
    Publication number: 20130331440
    Abstract: The present invention relates to compositions comprising an agent, like a polynucleotide, which induces or upregulates expression of UCP1 for use in treating or preventing a disorder of the energy homeostasis, overweight, adiposity, obesity, metabolic syndrome or related diseases or disorders in a subject. The present invention also relates to a method of treating or preventing a disorder of the energy homeostasis, overweight, adiposity, obesity, metabolic syndrome or related diseases or disorders in a subject comprising administrating a composition comprising a polynucleotide which induces or upregulates expression of UCP1.
    Type: Application
    Filed: May 6, 2011
    Publication date: December 12, 2013
    Applicant: TECHNISCHE UNIVERSITAT GRAZ
    Inventors: Marcel Scheideler, Michael Karbiener, Ez-Zoubir Amri, Gérard Ailhaud, Christian Dani
  • ESTABLISHED HUMAN BROWN ADIPOCYTE LINE AND METHOD FOR DIFFERENTIATION FROM AN HMADS CELL LINE
    Publication number: 20110117066
    Abstract: The subject matter of the invention is a functional population of human brown adipocytes, in which the expression of UCP1, CIDEA, CPT1B and Bcl2 is higher, the expression of Bax is lower and the expression of PPAR-alpha, PGC-1alpha, PGC-1beta and PRDM16 is similar compared with the corresponding expressions of a population of human white adipocytes. The invention also relates to a method for differentiation of hMADS cells into the functional population of human brown adipocytes, to a method for conversion of a population of human white adipocytes into the functional population of human brown adipocytes, and also to a method of screening for molecules capable of modulating the bodyweight in an individual.
    Type: Application
    Filed: June 23, 2009
    Publication date: May 19, 2011
    Applicants: UNIVERSITE DE NICE SOPHIA ANTIPOLIS
    Inventors: Gérard Paul Ailhaud, Ez-Zoubir Amri, Christian Jean Lucien Dani, Christian Elabd