Patents by Inventor Ezra Schildkraut

Ezra Schildkraut has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods Relating to Synthetic RNA Polynucleotides Created From Synthetic DNA Oligonucleotides
    Publication number: 20220333098
    Abstract: Compositions and methods are provided for forming a single RNA polynucleotide from a plurality of DNA oligonucleotides in a single reaction chamber using combined reagents in a single step reaction.
    Type: Application
    Filed: June 22, 2022
    Publication date: October 20, 2022
    Applicant: New England Biolabs, Inc.
    Inventors: G. B. Robb, Isaac B. Meek, Dianne S. Schwarz, Ezra Schildkraut
  • Compositions and methods relating to synthetic RNA polynucleotides created from synthetic DNA oligonucleotides
    Patent number: 11396652
    Abstract: Compositions and methods are provided for forming a single RNA polynucleotide from a plurality of DNA oligonucleotides in a single reaction chamber using combined reagents in a single step reaction. DNA polymerase, RNA polymerase and single stranded (ss) DNA oligonucleotides are combined where each DNA oligonucleotide has one or more sequence modules, wherein one sequence module in the first ss DNA oligonucleotide is complementary to a sequence module at the 3? end of the second ss DNA oligonucleotide; and wherein a second module on the first ss DNA oligonucleotide is an RNA polymerase promoter sequence; and forming a single RNA polynucleotide, excluding the RNA promoter sequence, derived from the first and second DNA oligonucleotides.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: July 26, 2022
    Assignee: New England Biolabs, Inc.
    Inventors: G. B. Robb, Isaac B. Meek, Dianne S. Schwarz, Ezra Schildkraut
  • Compositions and Methods Relating to Synthetic RNA Polynucleotides Created From Synthetic DNA Oligonucleotides
    Publication number: 20190225961
    Abstract: Compositions and methods are provided for forming a single RNA polynucleotide from a plurality of DNA oligonucleotides in a single reaction chamber using combined reagents in a single step reaction.
    Type: Application
    Filed: April 4, 2019
    Publication date: July 25, 2019
    Applicant: New England Biolabs, Inc.
    Inventors: G. B. Robb, Isaac B. Meek, Dianne S. Schwarz, Ezra Schildkraut
  • Compositions and methods relating to synthetic RNA polynucleotides created from synthetic DNA oligonucleotides
    Patent number: 10301619
    Abstract: Compositions and methods are provided for forming a single RNA polynucleotide from a plurality of DNA oligonucleotides in a single reaction chamber using combined reagents in a single step reaction. DNA polymerase, RNA polymerase and single stranded (ss) DNA oligonucleotides are combined where each DNA oligonucleotide has one or more sequence modules, wherein one sequence module in the first ss DNA oligonucleotide is complementary to a sequence module at the 3? end of the second ss DNA oligonucleotide; and wherein a second module on the first ss DNA oligonucleotide is an RNA polymerase promoter sequence; and forming a single RNA polynucleotide, excluding the RNA promoter sequence, derived from the first and second DNA oligonucleotides.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: May 28, 2019
    Assignee: New England Biolabs, Inc.
    Inventors: G. B. Robb, Isaac B. Meek, Dianne S. Schwarz, Ezra Schildkraut
  • Compositions and methods relating to synthetic RNA polynucleotides created from synthetic DNA oligonucleotides
    Publication number: 20170283797
    Abstract: Compositions and methods are provided for forming a single RNA polynucleotide from a plurality of DNA oligonucleotides in a single reaction chamber using combined reagents in a single step reaction.
    Type: Application
    Filed: March 27, 2017
    Publication date: October 5, 2017
    Applicant: New England Biolabs, Inc.
    Inventors: G. B. Robb, Isaac B. Meek, Dianne S. Schwarz, Ezra Schildkraut
  • Discovery, Cloning and Purification of Thermococccus sp. (Strain 9 Degrees N-7) Dna Ligase
    Publication number: 20090142811
    Abstract: Compositions that describe a thermostable DNA ligase isolated from Thermococcus sp. (strain 9° N-7) and methods for making und using the same are described. The thermostable DMA ligase depends on ATP and not NAD+ as a cofactor during ligation, and retains activity at 100° C.
    Type: Application
    Filed: September 15, 2006
    Publication date: June 4, 2009
    Applicant: New England Biolabs, Inc.
    Inventors: Ira Schildkraut, Ezra Schildkraut