Patents by Inventor Ezra Van Gelder
Ezra Van Gelder has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230405589Abstract: A system for controlling custody of a sample can include a cartridge comprising a sample receptacle configured to receive an article configured to deliver a sample to the cartridge, a cartridge module having a cartridge receptacle configured to receive the cartridge; a housing enclosing the cartridge module and the cartridge. The housing can include a closable door; at least one sensor configured to produce a signal indicating: insertion or removal of an article into or from the sample receptacle; whether the cartridge is inserted into the cartridge receptacle; or whether the door is open or closed. The system can further include a computer programmed to record a signal from the at least one sensor for a recording period of time and to display a signal history to a user.Type: ApplicationFiled: September 11, 2023Publication date: December 21, 2023Applicant: IntegenX, Inc.Inventors: William D. Nielsen, Richard J. Belcinski, Gregory Bogdan, David Eberhart, Omar El-Sissi, Stevan B. Jovanovich, Michael Recknor, Ezra Van Gelder, David W. Wyrick
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Publication number: 20230314324Abstract: Compositions, systems, and methods are disclosed for preparing and utilizing arrays, such as single-analyte arrays containing a plurality of fiducial elements with random spatial distributions. Arrays may be prepared with pluralities of fiducial elements comprising optically active or passive moieties. Arrays containing random spatial distributions of fiducial elements may be utilized for various array-based processes that require spatial information.Type: ApplicationFiled: March 29, 2023Publication date: October 5, 2023Inventors: Maryam JOUZI, Torri Elise RINKER, Pengyu HAO, Vadim LOBANOV, Ryan Kempston SEGHERS, Daniel HORNER, Pierre INDERMUHLE, David STERN, Ezra VAN GELDER, Kevin CHEN
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Publication number: 20230287480Abstract: Systems for optically detecting single-analytes, such as cells, nucleic acids, and polypeptides, are described. The described optical detection systems are suitable for multiplexed detection of single-analytes, including single-analytes provided in an array-based format. Methods for identifying single-analyte properties and interactions utilizing optical detection systems are provided.Type: ApplicationFiled: March 8, 2023Publication date: September 14, 2023Inventors: David STERN, Glenn CHAN, Ezra VAN GELDER
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Patent number: 11684918Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.Type: GrantFiled: November 27, 2019Date of Patent: June 27, 2023Assignee: INTEGENX, INC.Inventors: William D. Nielsen, Richard J. Belcinski, Gregory Bogdan, David Eberhart, Omar El-Sissi, Stevan B. Jovanovich, Michael Recknor, Ezra Van Gelder, David Wyrick
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Publication number: 20210277445Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.Type: ApplicationFiled: December 11, 2020Publication date: September 9, 2021Inventors: David Eberhart, Yuan Li, James Ogg, Ezra Van Gelder, Stephen J. Williams, Timothy Woudenberg, Dean S. Burgi, William D. Nielsen
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Patent number: 10865440Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.Type: GrantFiled: February 28, 2013Date of Patent: December 15, 2020Assignee: IntegenX, Inc.Inventors: David Eberhart, Yuan Li, James Ogg, Ezra Van Gelder, Stephen J. Williams, Timothy Woudenberg, Dean S. Burgi, William D. Nielsen
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Publication number: 20200108388Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.Type: ApplicationFiled: November 27, 2019Publication date: April 9, 2020Inventors: William D. Nielsen, Richard J. Belcinski, Gregory Bogdan, David Eberhart, Omar El-Sissi, Stevan B. Jovanovich, Michael Recknor, Ezra Van Gelder, David Wyrick
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Patent number: 10525467Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.Type: GrantFiled: November 3, 2016Date of Patent: January 7, 2020Assignee: IntegenX Inc.Inventors: William D. Nielsen, Richard J. Belcinski, Gregory Bogdan, David Eberhart, Omar EL-Sissi, Stevan B. Jovanovich, Michael Recknor, Ezra Van Gelder, David W. Wyrick
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Publication number: 20170197213Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.Type: ApplicationFiled: November 3, 2016Publication date: July 13, 2017Inventors: William D. Nielsen, Richard J. Belcinski, Gregory Bogdan, David Eberhart, Omar EL-Sissi, Stevan B. Jovanovich, Michael Recknor, Ezra Van Gelder, David W. Wyrick
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Patent number: 9663819Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.Type: GrantFiled: November 24, 2014Date of Patent: May 30, 2017Assignee: INTEGENX INC.Inventors: Stevan B. Jovanovich, William D. Nielsen, Mattias Vangbo, Ezra Van Gelder, Omar El-Sissi
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Publication number: 20160016140Abstract: The invention provides systems, devices, methods, and kits for performing an integrated analysis. The integrated analysis can include sample processing, library construction, amplification, and sequencing. The integrated analysis can be performed within one or more modules that are fluidically connected to each other. The one or more modules can be controlled and/or automated by a computer. The integrated analysis can be performed on a tissue sample, a clinical sample, or an environmental sample. The integrated analysis system can have a compact format and return results within a designated period of time.Type: ApplicationFiled: July 21, 2015Publication date: January 21, 2016Applicant: INTEGENX INC.Inventors: Stevan B. Jovanovich, Seth Stern, Ezra Van Gelder, Mattias Vangbo
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Publication number: 20150136604Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.Type: ApplicationFiled: September 29, 2014Publication date: May 21, 2015Inventors: William D. NIELSEN, Richard J. BELCINSKI, Gregory BOGDAN, David EBERHART, Omar EL-SISSI, Stevan B. JOVANOVICH, Michael RECKNOR, Ezra VAN GELDER, David W. WYRICK
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Publication number: 20150136602Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.Type: ApplicationFiled: November 24, 2014Publication date: May 21, 2015Inventors: Stevan B. Jovanovich, William D. Nielsen, David S. Cohen, Michael Recknor, Mattias Vangbo, Ezra Van Gelder, Lars Majlof, Omar El-Sissi
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Patent number: 9012236Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.Type: GrantFiled: August 15, 2013Date of Patent: April 21, 2015Assignee: IntegenX Inc.Inventors: Stevan B. Jovanovich, William D. Nielsen, David S. Cohen, Michael Recknor, Mattias Vangbo, Ezra Van Gelder, Omar El-Sissi
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Publication number: 20150024436Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.Type: ApplicationFiled: February 28, 2013Publication date: January 22, 2015Applicant: INTEGENX INC,Inventors: David Eberhart, Yuan Li, James Ogg, Ezra Van Gelder, Stephen J. Williams, Timothy Woudenberg, Dean S. Burgi, William D. Nielsen
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Patent number: 8894946Abstract: This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is DNA and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an STR (short tandem repeat) profile, for example as used in the CODIS system. The system can perform several operations, including (a) extraction and isolation of nucleic acid; (b) amplification of nucleotide sequences at selected loci (e.g., genetic loci); and (c) detection and analysis of amplification product. These operations can be carried out in a system that comprises several integrated modules, including an analyte preparation module; a detection and analysis module and a control module.Type: GrantFiled: October 19, 2012Date of Patent: November 25, 2014Assignee: IntegenX Inc.Inventors: William D. Nielsen, Richard J. Belcinski, Gregory Bogdan, David Eberhart, Omar El-Sissi, Stevan B. Jovanovich, Michael Recknor, Ezra Van Gelder, David W. Wyrick
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Publication number: 20140170645Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.Type: ApplicationFiled: August 15, 2013Publication date: June 19, 2014Applicant: IntegenX Inc.Inventors: Stevan B. Jovanovich, William D. Nielsen, David S. Cohen, Michael Recknor, Mattias Vangbo, Ezra Van Gelder, Lars Majlof, Omar El-Sissi
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Publication number: 20140065628Abstract: The disclosure provides methods and devices for separating and detecting nucleic acid fragments labeled with a plurality of spectrally resolvable dyes using a single light source or multiple light sources. Use of a greater number of light sources increases the number of spectrally resolvable dyes that can be interrogated. Labeling fragments with a greater number of spectrally resolvable dyes permits more overlapping of fragments with differentiation of the fragments, and thus separation can be conducted on a smaller range of fragment sizes/lengths. To improve the detection sensitivity of a detection system employing multiple light sources, light emitted by the light sources can be spatially separated from one another and/or the intensity of each of the light sources can be modulated. Each of the one or more light sources can be, e.g., a laser or a light-emitting diode. The methods and devices of the disclosure are useful for performing genetic analysis, e.g.Type: ApplicationFiled: August 13, 2013Publication date: March 6, 2014Applicant: IntegenX Inc.Inventors: Ezra Van Gelder, Stephen J. Williams
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Patent number: 8584703Abstract: This invention provides composite plastic articles and methods of making them. The articles can be fluidic or microfluidic devices having fluidic conduits and, optionally, pneumatic conduits that regulate flow in the fluidic conduits. The articles comprise a first substrate coated with a layer of a material that comprises, or onto which have been introduced, reactive groups. For example, the substrate can be a plastic coated with an oxide or a siloxane onto which hydroxyl groups have been introduced. These articles are covalently bonded with other articles comprising reactive groups on their surfaces, for example, polysiloxanes treated to have silanol groups. Certain articles have specified locations on their surfaces that are not bonded to the other piece. For example, the coating can be removed from these locations before bonding. Such locations can be useful as functional elements of various devices, such as valve seats in valves of microfluidic devices.Type: GrantFiled: November 18, 2010Date of Patent: November 19, 2013Assignee: IntegenX Inc.Inventors: Boris Kobrin, Iuliu I. Blaga, William Nielsen, Shize D. Qi, Ezra Van Gelder
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Patent number: 8562918Abstract: The invention provides a system that can process a raw biological sample, perform a biochemical reaction and provide an analysis readout. For example, the system can extract DNA from a swab, amplify STR loci from the DNA, and analyze the amplified loci and STR markers in the sample. The system integrates these functions by using microfluidic components to connect what can be macrofluidic functions. In one embodiment the system includes a sample purification module, a reaction module, a post-reaction clean-up module, a capillary electrophoresis module and a computer. In certain embodiments, the system includes a disposable cartridge for performing analyte capture. The cartridge can comprise a fluidic manifold having macrofluidic chambers mated with microfluidic chips that route the liquids between chambers. The system fits within an enclosure of no more than 10 ft3. and can be a closed, portable, and/or a battery operated system. The system can be used to go from raw sample to analysis in less than 4 hours.Type: GrantFiled: December 17, 2012Date of Patent: October 22, 2013Assignee: IntegenX Inc.Inventors: Stevan B. Jovanovich, William D. Nielsen, David S. Cohen, Michael Recknor, Mattias Vangbo, Ezra Van Gelder, Lars Majlof, Omar El-Sissi