Patents by Inventor F. Brunicardi

F. Brunicardi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treating hyperinsulinemia by killing beta cells with cytotoxic gene
    Publication number: 20050137157
    Abstract: This invention relates to a recombinant nucleic acid for an RIP-tk (rat insulin promoter-thymidine kinase) construct that selectively targets insulin secreting cells, such as ?-cells, PDX-1 positive human pancreatic ductal carcinomas, and other cells containing certain transcription factors. The present invention is useful in the treatment of hyperinsulinemia by targeting ?-cells that overproduce insulin with a cytotoxic gene.
    Type: Application
    Filed: September 24, 2004
    Publication date: June 23, 2005
    Applicant: Charles F. Brunicardi, M.D.
    Inventor: F. Brunicardi
  • Promoter driven tissue specific cytotoxic agents and title methods of use
    Publication number: 20050059620
    Abstract: This invention relates to a recombinant nucleic acid for an RIP-tk (rat insulin promoter-thymidine kinase) construct that selectively targets insulin secreting cells, such as ?-cells, PDX-1 positive human pancreatic ductal carcinomas, and other cells containing certain transcription factors. The present invention is useful in the treatment of pancreatic cancers, such as ?-cell insulinomas and can also be used to target pancreatic tumors that do not express insulin, such as pancreatic adenocarcinoma.
    Type: Application
    Filed: September 5, 2003
    Publication date: March 17, 2005
    Applicant: F. Charles Brunicardi
    Inventor: F. Brunicardi