Patents by Inventor F. Carl Grumet

F. Carl Grumet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Non-human primate monoclonal antibodies and methods
    Patent number: 4777245
    Abstract: A stable trioma cell line capable of secreting a non-human primate monoclonal antibody specific against a selected antigen. An exemplary cell line secretes chimpanzee monoclonal antibody specific against an antigen associated with hepatitis nonA/nonB infection. The cell line is produced, in the method of the invention, by isolating lymphocytes from a primate immunized with the selected antigen, and immortalizing the lymphocytes by fusion with a stable, non-antibody-secreting murine myeloma/human hybridoma cell line having selected-for human characteristics. The trioma fusion products are selected for secretion of the desired antibody, which has a variety of diagnostic and/or therapeutic uses.
    Type: Grant
    Filed: August 19, 1985
    Date of Patent: October 11, 1988
    Assignee: Genelabs Incorporated
    Inventors: Steven K. H. Foung, Judith A. Blunt, Linda B. Rabin, F. Carl Grumet, Edgar G. Engleman
  • Human monoclonal antibody against group A red blood cells
    Patent number: 4764465
    Abstract: A human monoclonal antibody that directly agglutinates type A human red blood cells is described. The exemplified antibody is an IgM and is produced by hybrid cells lines S-H22 and HHA1. The antibody is useful as an ABO typing reagent.
    Type: Grant
    Filed: September 30, 1986
    Date of Patent: August 16, 1988
    Assignees: Cetus Corporation, The Board of Trustees of the Leland Stanford Junior University
    Inventors: Steven K. H. Foung, Andrew R. Raubitschek, Edgar G. Engleman, F. Carl Grumet, James W. Larrick
  • Human-murine hybridoma fusion partner
    Patent number: 4634666
    Abstract: By careful screening and mutation, a human-murine hybridoma suitable as a fusion partner for immortalizing an antibody-secreting B cell has been generated. The trioma fusion products of this immortalizing partner are stable producers of human monoclonal antibodies. A trioma which produces monoclonal human anti-varicella zoster is disclosed.
    Type: Grant
    Filed: January 6, 1984
    Date of Patent: January 6, 1987
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Edgar G. Engleman, Steven K. H. Foung, F. Carl Grumet
  • Fluorescent determination of microlymphocytotoxicity
    Patent number: 4532203
    Abstract: Improved results are achieved in fluorochromasia lymphocytotoxicity for cell typing by adding antifluorescer to reduce background fluorescence as a result of cell lysing.
    Type: Grant
    Filed: October 26, 1982
    Date of Patent: July 30, 1985
    Assignee: SYVA Company
    Inventors: Edwin F. Ullman, F. Carl Grumet