Patents by Inventor F. Edward Roberts

F. Edward Roberts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conversion of indene to (1S)-amino-(2R)-indanol free of any stereoisomer, by combination of dioxygenase bioconversion and chemical steps
    Patent number: 5858737
    Abstract: A process is disclosed that bioconverts indene to (1S)-amino-(2R)-indanol substantially free of any of its stereoisomers, by the action of a strain of P. putida or Rhodococcus sp., followed by various chemical step(s), e.g., chiral specific crystallization, treatment with strong acid in the presence of acetonitrile.
    Type: Grant
    Filed: August 14, 1996
    Date of Patent: January 12, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Barry C. Buckland, Neal C. Connors, Michel M. Chartrain, Francis P. Gailliot, Randolph L. Greasham, Barbara Jackey, Brian Heimbuch, Chanyong Lee, Roger C. Olewinski, Jr., F. Edward Roberts, Paul J. Reider, Thomas R. Verhoeven, Chris H. Senanayake
  • Regiospecific processes to make cis-1-amino-2-alkanol from diol
    Patent number: 5489710
    Abstract: A regioselective processes are disclosed for the synthesis of (1R,1S)-amino-(2S,2R)-alkanol, particularly (1R,1S)-amino-(2S,2R)-indanol.
    Type: Grant
    Filed: April 19, 1995
    Date of Patent: February 6, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Thomas R. Verhoeven, F. Edward Roberts, Chris H. Senanayake, Kenneth M. Ryan
  • Regiospecific process to make cis-1-amino-2-alkanol from epoxide
    Patent number: 5420353
    Abstract: A regioselective process is disclosed for synthesis of 1R-amino-2S-indanol or 1S-amino-2R-indanol, wherein the stereochemical integrity of the carbon-oxygen bond at C-2 in the indene oxide starting material is retained.
    Type: Grant
    Filed: March 11, 1994
    Date of Patent: May 30, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Thomas R. Verhoeven, F. Edward Roberts, Christ H. Senanayake, Kenneth M. Ryan
  • Enantiospecific synthesis of S-(+)-5,6-dihydro-4-(R-amino)-4H-thieno(2,3-b)thiopyran-2-sulfonamide-7, 7-dioxide
    Patent number: 5157129
    Abstract: 5,6-Dihydro-4-(R-amino)-4H-thieno[2,3-b]-thiopyran-2-sulfonamide-7,7-dioxid e is a potent carbonic anhydrase inhibitor useful in the treatment of ocular hypertension and glaucoma. The S-(+)-enantiomer of that compound, the more active enantiomer, is prepared by a process involving an intermediate step of an enantioselective reduction of a carbonyl group employing an oxazaborolidine chiral catalyst.
    Type: Grant
    Filed: April 18, 1990
    Date of Patent: October 20, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Thomas J. Blacklock, Todd K. Jones, Edward J. J. Grabowski, David J. Mathre, Julie J. Mohan, Paul Sohar, F. Edward Roberts, Lyndon C. Xavier
  • Deblocking process for allyl esters with regeneratable polymer supported Pd(O)
    Patent number: 5124448
    Abstract: A regeneratable polymer-supported Pd(O) catalytic deblocking process using a regeneratable polymer-supported Pd(O) catalyst in a biphasic system deblocks various allyl-protected ester, carbonates, carbamates and cinnamyl esters.
    Type: Grant
    Filed: November 7, 1990
    Date of Patent: June 23, 1992
    Assignee: Merck & Co., Inc.
    Inventors: David M. Tschaen, F. Edward Roberts, Thomas R. Verhoeven
  • Process for removal of homogeneous catalyst group VIII metals from process streams
    Patent number: 4413118
    Abstract: Organic sulfur compounds containing a carbon-sulfur double bond are used to remove homogeneous catalyst group VIII metals from chemical process streams.
    Type: Grant
    Filed: March 2, 1981
    Date of Patent: November 1, 1983
    Assignee: Merck & Co., Inc.
    Inventors: F. Edward Roberts, Victor J. Grenda