Patents by Inventor F. Gregory Spence

F. Gregory Spence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the manufacture of (S)-3-amino-1-substituted-pyrrolidines
    Patent number: 5250704
    Abstract: A novel process for preparing a stereospecific (S)-3-amino-1-substituted pyrrolidine used as a key intermediate in preparing quinolone and naphthyridone antibacterial agents where the 7-position is occupied with a sterospecific 3-aminopyrrolidine side chain is described starting from inexpensive L-aspartic acid. L-aspartic acid is converted to the desired (S)-3-aminopyrrolidine via a novel, high yield transformation of a substituted aziridine.
    Type: Grant
    Filed: September 10, 1992
    Date of Patent: October 5, 1993
    Assignee: Warner-Lambert Company
    Inventors: Tung Van Le, F. Gregory Spence, James N. Wemple
  • Process for the manufacture of (S)-3-amino-1-substituted-pyrrolidines
    Patent number: 5177217
    Abstract: A novel process for preparing a stereospecific (S)-3-amino-1-substituted pyrrolidine used as a key intermediate in preparing quinolone and naphthyridone antibacterial agents where the 7-position is occupied with a sterospecific 3-amino-pyrrolidine side chain is described starting from inexpensive L-aspartic acid. L-aspartic acid is converted to the desired (S)-3-aminopyrrolidine via a novel, high yield transformation of a substituted aziridine.
    Type: Grant
    Filed: April 27, 1992
    Date of Patent: January 5, 1993
    Assignee: Warner-Lambert Company
    Inventors: Tung Van Le, F. Gregory Spence, James N. Wemple