Abstract: Provided is a method for enabling accurate and consistent imaging of selected colors within a document for various printing device configurations utilizing an automated spot color editor. The method includes determining appropriate target values for a selected color within a print job. The automated spot color editor modifies or adjusts the selected color by selecting a quality level, in the form of a color difference metric, and a maximum number of iterations, which is the maximum number of times the automated spot color editor is operated to calculate a CMYK color formula. Sample patch(es) are printed and analyzed for the selected target value and a CMYK color formula based on the color composition of the sample patch is calculated. The CMYK color formula is inserted into a spot color editing table. Through a graphical user interface, an operator may review the color formula for acceptance.

Abstract: A biosensor utilizing bio-functionalized magnetic nanoparticles is provided. An external magnetic field is applied to a suspension of magnetic nanoparticles. A linearly polarized incident light is applied to the suspension of magnetic nanoparticles. A photocurrent from polarized light scattering by bio-functionalized magnetic nanoparticles in liquid is detected. The magneto-optic sensing technique is applied to a micro-fluidic channel for rapid and sensitive detection with a small sample amount, and subsequent magnetic separation for detoxification. This technique is used for the detection of Brownian relaxation with time sweep as well as frequency sweep. The magneto-optical sensor enables rapidly detecting changes in local dynamic properties of the magnetic nanoparticles in liquids and magnetic modulation of ferromagnetic particles in liquid provides increased signal sensitivity.

Abstract: Disclosed are color management methods and systems to adaptively tune colors for one or more image marking devices. Specifically, exemplary embodiments include methods and systems to create profiles for preference color matching. For example, Lab values associated with target node colors can be warped using a predefined function for special regions of interest.

Abstract: A biosensor utilizing bio-functionalized magnetic nanoparticles is provided. An external magnetic field is applied to a suspension of magnetic nanoparticles. A linearly polarized incident light is applied to the suspension of magnetic nanoparticles. A photocurrent from polarized light scattering by bio-functionalized magnetic nanoparticles in liquid is detected. The magneto-optic sensing technique is applied to a micro-fluidic channel for rapid and sensitive detection with a small sample amount, and subsequent magnetic separation for detoxification. This technique is used for the detection of Brownian relaxation with time sweep as well as frequency sweep. The magneto-optical sensor enables rapidly detecting changes in local dynamic properties of the magnetic nanoparticles in liquids and magnetic modulation of ferromagnetic particles in liquid provides increased signal sensitivity.

Abstract: Provided is a method for enabling accurate and consistent imaging of selected colors within a document for various printing device configurations utilizing an automated spot color editor. The method includes determining appropriate target values for a selected color within a print job. The automated spot color editor modifies or adjusts the selected color by selecting a quality level, in the form of a color difference metric, and a maximum number of iterations, which is the maximum number of times the automated spot color editor is operated to calculate a CMYK color formula. Sample patch(es) are printed and analyzed for the selected target value and a CMYK color formula based on the color composition of the sample patch is calculated. The CMYK color formula is inserted into a spot color editing table. Through a graphical user interface, an operator may review the color formula for acceptance.

Abstract: A method of reversing epithelial mesenchymal transition, comprising the step of treating a fibrotic disease patient or cancer disease patient with an amount of kinase inhibitor capable of reversing EMT, wherein the kinase inhibitor comprises a TGF-?I kinase inhibitor and a Rho kinase inhibitor or a TGF-?I inhibitor and a p38 MAPK inhibitor is disclosed.

Abstract: A method for implementing miniaturization of magnetic random access memory (MRAM) and a magnetic memory using single domain switching by direct current are provided. The magnetic memory preferably includes a half-circle or U-shaped architecture with an exchange biasing pad, such as a FeMn exchange biasing pad that effectively generates a head-to-head magnetization configuration. The magnetic memory also includes nanometer scale notches in order to minimize magnetostatic interaction between a single domain memory element and the spin current sources and to effectively trap the magnetic domain wall. Reading the bit can be carried out by anisotropic magnetoresistance, or by other means of determining the magnetization orientation through resistance measurements, such as a spin valve or a magnetic tunneling junction.

Abstract: A non-metallic conveyor component is provided. The conveyor component includes an inner race and an outer race. The inner race includes an outer bearing surface. The outer race includes and inner bearing surface. One of the outer and inner bearing surfaces includes a helical groove. The inner and outer races are made from a polymeric matrix material having an alloying additive.

Abstract: A method of screening for selective inhibitors or activators Smad protein function is disclosed. In one embodiment, the invention comprises the steps of (a) obtaining a phosphorylated Smad protein or protein complex, (b) allowing the phosphorylated Smad protein or complex to interact with a target protein or peptide in the presence of a test compound, and (c) analyzing the binding of the phosphorylated Smad complex or protein and the target protein or peptide, wherein a perturbation of binding indicates that the test compound is an inhibitor or activator of Smad-target protein interaction.

Abstract: The present invention relates to quinazolinone compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

Abstract: A prosthesis for repairing a knee is made with an insert sandwiched between a femoral component and a tibial tray. The parts are shaped so that both the femoral component and the tibial tray will slidingly interface with the insert during motion of the knee. At regions where the femoral component interfaces with the insert during extension and during an initial range of flexion of the knee, the femoral component's radius of curvature (R1) for flexion rotation is larger than its radius of curvature (R3) for varus/valgus rotation. In a preferred embodiment, the surface of the tibial tray is convex and spherically curved, and the insert is free to move in both the posterior-anterior direction and the medial-lateral direction with respect to the tibial tray.

Abstract: A non-metallic conveyor component is provided. The conveyor component includes an inner race and an outer race. The inner race includes an outer bearing surface. The outer race includes and inner bearing surface. One of the outer and inner bearing surfaces includes a helical groove. The inner and outer races are made from a polymeric matrix material having an alloying additive.

Abstract: An enclosed track conveyor chain assembly and method of construction includes a plurality of guide link assemblies and load link assemblies connected to form a conveyor chain assembly. Each load link assembly includes a pair of side walls and forward and rearward ends defining an opening. A pair of wheel assemblies supports the load link on the horizontal surfaces of the track. A guide link member is inserted into the opening of adjacent load links. Distal ends of the guide links are connected via a fastener to thereby connect adjacent load link members to form the enclosed track chain. Each guide link member includes a plurality of flat areas on the distal ends of the arms to provide a connecting surface. A fastener is inserted through openings in the distal ends to secure the guide link members together. Preferably, the connection between guide link members is pivotal to allow pivoting action of the guide link.

Abstract: An enclosed track conveyor chain assembly and method of construction includes a plurality of guide link assemblies and load link assemblies connected to form a conveyor chain assembly. Each load link assembly includes a pair of side walls and forward and rearward ends defining an opening. A pair of wheel assemblies supports the load link on the horizontal surfaces of the track. A guide link member is inserted into the opening of adjacent load links. Distal ends of the guide links are connected via a fastener to thereby connect adjacent load link members to form the enclosed track chain. Each guide link member includes a plurality of flat areas on the distal ends of the arms to provide a connecting surface. A fastener is inserted through openings in the distal ends to secure the guide link members together. Preferably, the connection between guide link members is pivotal to allow pivoting action of the guide link.

Abstract: An enclosed track conveyor chain assembly and method of construction includes a plurality of guide link assemblies and load link assemblies connected to form a conveyor chain assembly. Each load link assembly includes a pair of side walls and forward and rearward ends defining an opening. A pair of wheel assemblies supports the load link on the horizontal surfaces of the track. A guide link member is inserted into the opening of adjacent load links. Distal ends of the guide links are connected via a fastener to thereby connect adjacent load link members to form the enclosed track chain. Each guide link member includes a plurality of flat areas on the distal ends of the arms to provide a connecting surface. A fastener is inserted through openings in the distal ends to secure the guide link members together. Preferably, the connection between guide link members is pivotal to allow pivoting action of the guide link.

Abstract: An apparatus for controlling use of electrically powered equipment includes an enclosure in which there is mounted an electrical connector receptacle which may be connected to a source of electrical power via its own power cable or plug blades. The enclosure is proportioned to receive the end of the electrical power cable or plug leads of one or more electrical power connectors of independently operated electrical devices. Plugging these devices into the electrical connector receptacle provides a direct, controlled connection to the power source. A locking device is provided on the exterior of the enclosure. This locking device could employ a variety of keyed and keyless lock designs. Disengaging the locking device unlocks the top enclosing lid of the enclosure to expose an electrical switch and a plurality of pins. When the electrical apparatus uses plug blades an attachment screw is also exposed to secure the electrical apparatus to the power source.

Abstract: A trolley wheel assembly (10) securely sealed to prevent loss of lubricant therefrom and entrance of contaminants therein. The assembly (10) comprises an inner race (12) disposed about an axis of rotation (14) and an outer race (16) concentrically disposed in a spaced relationship about the inner race (12). A plurality of ball bearings (18) are disposed between the inner race (12) and the outer race (16). An outer sealing ring (20) extends radially inwardly from the outer race (16) toward the inner race (12). An inner sealing ring (22) is rotatably disposed about the inner race (12), extending radially outwardly and contiguous the outer sealing ring (20). A wave washer (24) disposed about the inner race (12) biases the inner sealing ring (22) into constant friction engagement with the outer sealing ring (20). A plurality of backup inner sealing rings (26,27) provide a secondary seal about the inner race (12).

Abstract: Bromide ion content in a photographic developer is an important variable to be controlled by photoprocessors who process color reversal material or color negative film. The bromide content of such developers can be determined by titration with silver ion, using tetraiodophenolsulfonephthalein (TIPS) or other suitable adsorption indicator, after the developer has been acidified with an organic acid such as citric acid. This titrimetric method can be adapted for use in a test kit which is designed for use by photoprocessors who otherwise lack the chemical sophistication to readily conduct analysis by titration, or who have the necessary sophistication, but wish to gain the benefits and convenience available from use of a test kit specifically designed for conducting the analytical method.

Abstract: A wheel lock assembly for reversibly rotatably mounting a wheel assembly which comprises an inner race and an outer race and bearings disposed therebetween on a trolley which includes a central bore having a central axis and having a substantially annular recess eccentric relative to the central bore. The wheel lock assembly includes an axle member, the axle member including a cylindrical body portion having a longitudinal axis and an enlarged substantially annular head portion eccentric relative to the longitudinal axis. The wheel lock assembly further includes a cap member and locking screw for fastening the cap member to an end of the body portion of the axle member to draw the cap member into frictional engagement with the inner face and to draw the head portion of the axle member into mating engagement with the recess of the trolley arm.

Abstract: A link pin for connecting a pair of side links to a center link disposed therebetween including rectangular head portions at each end thereof for retaining the pin within the side and center links and a shaft portion disposed between the head portions. The shaft portion includes a pair of end portions and a central portion therebetween and a central axis extending therethrough and first and second offset axes which are parallel to the central axis and disposed on each side thereof. The shaft portion further includes a central protrusion extending from the central portion and radially outwardly from the first offset axis and having an outer arcuate surface defining an arc circumscribed about the first offset axis and a lateral protrusion extending from each of the end portions and radially outwardly from the second offset axis in a direction opposite to the central protrusion, each of the lateral protrusions having an outer surface defining an arc circumscribed about the second offset axis.