Patents by Inventor F.I.S. Fabbrica Italiana Sintetici S.p.A.

F.I.S. Fabbrica Italiana Sintetici S.p.A. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PREPARATION OF EFAVIRENZ
    Publication number: 20130165650
    Abstract: A process for the preparation of Efavirenz, (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one, of formula (I): comprising reacting the intermediate of formula (II): as a free base or a salt thereof, with diphosgene (TCMCF, trichloromethylchloroformate) Cl3CO—COCl in an organic solvent or in a biphasic medium comprised of an organic solvent and water, preferably but not mandatorily in the presence of a weak base in an amount sufficient to neutralize the reaction mixture or in an up to 30% molar excess of such amount.
    Type: Application
    Filed: February 26, 2013
    Publication date: June 27, 2013
    Applicant: F.I.S. Fabbrica Italiana Sintetici S.p.A
    Inventor: F.I.S. Fabbrica Italiana Sintetici S.p.A
  • CO-CRYSTAL INTERMEDIATES OF ROSUVASTATIN AND METHODS OF USING SAME
    Publication number: 20130143890
    Abstract: Methods for the preparation of Rosuvastatin by co-crystals of Rosuvastatin or intermediates are provided. Also provided are co-crystals, pharmaceutical compositions which include such co-crystals and methods for treating conditions associated with hypercholesterolemia by administering such compositions.
    Type: Application
    Filed: December 3, 2012
    Publication date: June 6, 2013
    Applicant: F.I.S. Fabbrica Italiana Sintetici S.p.A.
    Inventor: F.I.S. Fabbrica Italiana Sintetici S.p.A.