Patents by Inventor F. Mark H. Jeffrey

F. Mark H. Jeffrey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of determining sources of acetyl-CoA under nonsteady-state conditions
    Patent number: 5413917
    Abstract: The present invention relates to a method of measuring the contribution of one or more exogenously administered .sup.13 C-labeled substrates to acetyl-CoA. The measurement can be made in a tissue or cell using .sup.13 C NMR without the constraint of metabolic or isotopic steady-state. Furthermore, the method permits the determination even when spectral lines are broad due to B.sub.0 inhomogeneity, thereby opening the way for substrate utilization studies in vivo. The method does not require many of the simplifying assumptions involved in .sup.11 C or .sup.14 C methods, and, since a stable isotope, .sup.13 C, is used a wide variety of compounds with complex labeling patterns may be synthesized and studied.
    Type: Grant
    Filed: July 18, 1990
    Date of Patent: May 9, 1995
    Assignee: Board of Regents, The University of Texas System
    Inventors: Craig R. Malloy, F. Mark H. Jeffrey, A. Dean Sherry