Patents by Inventor F. Michael Hoffmann

F. Michael Hoffmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biemamides and related scaffolds as inhibitors of transforming growth factor-beta signaling
    Patent number: 11618734
    Abstract: The present technology provides an isolated compound of Formula I, compositions including such compounds, methods of inhibiting TGF-? signaling and/or TGF-? induced epithelial mesenchymal transitions (EMT), and treating certain cancers involving TGF-? signaling and/or EMT.
    Type: Grant
    Filed: December 15, 2020
    Date of Patent: April 4, 2023
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Timothy Bugni, Fan Zhang, Douglas Braun, Gene Ananiev, F. Michael Hoffmann
  • BIEMAMIDES AND RELATED SCAFFOLDS AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA SIGNALING
    Publication number: 20210107879
    Abstract: The present technology provides an isolated compound of Formula I, compositions including such compounds, methods of inhibiting TGF-? signaling and/or TGF-? induced epithelial mesenchymal transitions (EMT), and treating certain cancers involving TGF-? signaling and/or EMT.
    Type: Application
    Filed: December 15, 2020
    Publication date: April 15, 2021
    Inventors: Timothy Bugni, Fan Zhang, Douglas Braun, Gene Ananiev, F. Michael Hoffmann
  • Biemamides and related scaffolds as inhibitors of transforming growth factor-beta signaling
    Patent number: 10889551
    Abstract: The present technology provides an isolated compound of Formula I, compositions including such compounds, methods of inhibiting TGF-? signaling and/or TGF-? induced epithelial mesenchymal transitions (EMT), and treating certain cancers involving TGF-? signaling and/or EMT.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: January 12, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Timothy Bugni, Fan Zhang, Douglas Braun, Gene Ananiev, F. Michael Hoffmann
  • BIEMAMIDES AND RELATED SCAFFOLDS AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA SIGNALING
    Publication number: 20200062715
    Abstract: The present technology provides an isolated compound of Formula I, compositions including such compounds, methods of inhibiting TGF-? signaling and/or TGF-? induced epithelial mesenchymal transitions (EMT), and treating certain cancers involving TGF-? signaling and/or EMT.
    Type: Application
    Filed: August 26, 2019
    Publication date: February 27, 2020
    Inventors: Timothy Bugni, Fan Zhang, Douglas Braun, Gene Ananiev, F. Michael Hoffmann
  • ANTI-RESTENOSIS COMPOSITIONS AND METHODS
    Publication number: 20150011492
    Abstract: The present invention relates generally to the pathology of restenosis. In particular, provided herein are devices comprising a compound that selectively decreasing smooth muscle cell proliferation without a substantial decrease in endothelial cell proliferation. Also provided are methods of using such devices to treat, prevent, or reduce vascular disease or the likelihood of restenosis following angioplasty.
    Type: Application
    Filed: July 2, 2014
    Publication date: January 8, 2015
    Inventors: F. Michael Hoffmann, K. Craig Kent, Shakti Goel, Lian-Wang Guo, Toshio Takayama
  • Screen for selective inhibitors or activators of Smad protein function
    Patent number: 6998240
    Abstract: A method of screening for selective inhibitors or activators Smad protein function is disclosed. In one embodiment, the invention comprises the steps of (a) obtaining a phosphorylated Smad protein or protein complex, (b) allowing the phosphorylated Smad protein or complex to interact with a target protein or peptide in the presence of a test compound, and (c) analyzing the binding of the phosphorylated Smad complex or protein and the target protein or peptide, wherein a perturbation of binding indicates that the test compound is an inhibitor or activator of Smad-target protein interaction.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: February 14, 2006
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: F. Michael Hoffmann, Allen R. Comer