Patents by Inventor Füsûn N. Zeytin

Füsûn N. Zeytin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Resonance energy transfer assay with synaptobrevin substrate moiety
    Patent number: 9453254
    Abstract: Compositions and methods for analyzing intracellular BoNT protease activity, and especially BoNT/B, BoNT/G, BoNT/D, and/or BoNT/F protease activity are provided. Most preferably, cells express one or more recombinant hybrid proteins that include one or more fluorescent proteins and at least one BoNT protease recognition and cleavage sequence, and analysis is performed using FRET analysis.
    Type: Grant
    Filed: October 15, 2010
    Date of Patent: September 27, 2016
    Assignee: BIOMADISON, INC.
    Inventors: Ward C. Tucker, Füsûn N. Zeytin
  • Thiazoline ring compounds as botulinum antagonists
    Patent number: 8569346
    Abstract: Compositions and methods for inhibiting BoNT protease activity are presented. In most preferred aspects, inhibitors comprise a thiol reactive group, a zinc binding group, a redox active group, an alkylating group, and/or an electrophilic Michael addition acceptor group. Particularly preferred inhibitors include an isothiazolone ring, a thiadiazolidine dione ring, a (hydro)quinone ring, an iminophenol group, and/or a hydrazonophenol group, and inhibit BoNT/A at ?M and sub-?M concentrations.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: October 29, 2013
    Assignee: Biomadison, Inc.
    Inventors: Füsûn N. Zeytin, Ward Tucker
  • Resonance Energy Transfer Assay with Synaptobrevin Substrate Moiety
    Publication number: 20120322092
    Abstract: Compositions and methods for analyzing intracellular BoNT protease activity, and especially BoNT/B, BoNT/G, BoNT/D, and/or BoNT/F protease activity are provided. Most preferably, cells express one or more recombinant hybrid proteins that include one or more fluorescent proteins and at least one BoNT protease recognition and cleavage sequence, and analysis is performed using FRET analysis.
    Type: Application
    Filed: October 15, 2010
    Publication date: December 20, 2012
    Inventors: Ward C. Tucker, Füsûn N. Zeytin