Patents by Inventor Fabian Model

Fabian Model has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11186879
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: June 26, 2019
    Date of Patent: November 30, 2021
    Assignee: EPIGENOMICS AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Patent number: 10731215
    Abstract: Aspects of the present invention relate to compositions and methods for providing DNA fragments from a remote sample. In particular aspects a remote sample comprising DNA is provided, DNA is isolated from the remote sample, and the isolated DNA is treated in a way which allows differentiation of methylated and unmethylated cytosine. Additional, particular embodiments provide compositions and methods for methylation analysis of DNA derived from a remote sample. Other aspects provide for compositions and methods of whole genome amplification of bisulfite treated DNA. Other aspects provide methods for determining the presence or absence of methylation of at least one cytosine, or a series of cytosines in cis, in human DNA of a blood sample, a plasma sample, a serum sample or a urine sample from a human individual.
    Type: Grant
    Filed: April 17, 2006
    Date of Patent: August 4, 2020
    Assignee: EPIGENOMICS AG
    Inventors: Matthias Ballhause, Kurt Berlin, Theo De Vos, Dimo Dietrich, Volker Liebenberg, Catherine Lofton-Day, Joe Lograsso, Jennifer Maas, Fabian Model, Matthias Schuster, Andrew Z. Sledziewski, Reimo Tetzner
  • Publication number: 20190316210
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: June 26, 2019
    Publication date: October 17, 2019
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Patent number: 10385402
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: August 20, 2019
    Assignee: EPIGENOMICS AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Publication number: 20190119760
    Abstract: The invention provides methods, nucleic acids and kits for detecting colorectal cell proliferative disorders based on underexpression or methylation of a least one gene selected from RASSF2, TFAP2E, SNDI, PCDHGC3, EDNRB, STOM, GLI3, RXFP3, LimK1, GPR73L1, PCDH1O, DOCKIO and MRPS21, and optionally Septin-9.
    Type: Application
    Filed: September 26, 2018
    Publication date: April 25, 2019
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Fabian Model, Susan Cottrell, Juergen Distler, Reimo Tetzner, Dimo Dietrich
  • Patent number: 9850532
    Abstract: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: December 26, 2017
    Assignee: EPIGENOMICS AG
    Inventors: Andrew Z. Sledziewski, Catherine E. Lofton-Day, Reimo Tetzner, Juergen Distler, Fabian Model, Shannon Payne
  • Publication number: 20170322225
    Abstract: Subject of the present invention are biomarkers and methods for the identification of risk for subsequent cardiovascular event (e.g. coronary heart disease death, non-fatal myocardial infarction, ischemic stroke, hospitalizations for unstable angina pectotis, cardiac arrest) in patients that have experienced an acute coronary syndrome, comprising the detecting the level of NT-proBNP, homocysteine and CRP.
    Type: Application
    Filed: April 21, 2017
    Publication date: November 9, 2017
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Thomas Dieterle, Eric J. Niesor, Rosemarie Kientsch-Engel, Horst Klima, Fabian Model, Gabriela Bucklar, Vinzent Rolny
  • Publication number: 20170283880
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: April 3, 2017
    Publication date: October 5, 2017
    Inventors: Catherine Lofton-Day, Fabian Model, Andrew Sledziewski, Tamas Rujan, Joern Lewin, Juergen Distler
  • Patent number: 9695478
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: July 4, 2017
    Assignee: EPIGENOMICS AG
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Patent number: 9605306
    Abstract: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: April 28, 2014
    Date of Patent: March 28, 2017
    Assignee: EPIGENOMICS AG
    Inventors: Andrew Z. Sledziewski, Catherine E. Lofton-Day, Reimo Tetzner, Juergen Distler, Fabian Model, Shannon Payne, Dimo Dietrich
  • Publication number: 20170067120
    Abstract: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: August 17, 2016
    Publication date: March 9, 2017
    Inventors: Andrew Z. Sledziewski, Catherine E. Lofton-Day, Reimo Tetzner, Juergen Distler, Fabian Model, Shannon Payne, Dimo Dietrich
  • Publication number: 20160369356
    Abstract: Particular aspects provide methods, nucleic acids and kits for detecting cell proliferative disorders. Preferred aspects provide genomic sequences, the methylation patterns of which have substantial utility for the improved detection of said disorders, providing for improved diagnosis and treatment of same in patients.
    Type: Application
    Filed: September 6, 2016
    Publication date: December 22, 2016
    Inventors: Volker Liebenberg, Juergen Distler, Joern Lewin, Fabian Model, Reimo Tetzner, Rene Cortese, Dimo Dietrich, Thomas Schlegel
  • Publication number: 20160312287
    Abstract: Particular aspects provide novel methods and compositions (e.g., nucleic acids, kits, etc.) having substantial utility for providing a prognosis of prostate cell proliferative disorders. In particular aspects, this is achieved by the analysis of the expression status of a panel of genes, or subsets thereof.
    Type: Application
    Filed: December 23, 2015
    Publication date: October 27, 2016
    Inventors: Susan Cottrell, Fabian Model, Carolina Haefliger, Gunter Weiss, Juergen Distler, Andrew Z. Sledziewski, Xiaoling Song, Thomas L. Skillman, Jeffrey G. Thomas
  • Publication number: 20160304964
    Abstract: The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: March 23, 2016
    Publication date: October 20, 2016
    Inventors: Catherine E. Lofton-Day, Andrew Z. Sledziewski, Ralf Lesche, Matthias Schuster, Juergen Distler, Reimo Tetzner, Thomas Hildmann, Fabian Model, Xiaoling Song
  • Publication number: 20150268251
    Abstract: The present invention relates to a method for identifying a subject being eligible to the administration of at least one medicament selected from the group consisting of a beta blocker, an aldosterone antagonist, a diuretic, and an inhibitor of the renin-angiotensin system. The method is based on the determination of the amount of at least one biomarker selected from the group consisting of GDF-15 (Growth Differentiation Factor 15), endostatin, mimecan, IGFBP7 (IGF binding protein 7), a cardiac Troponin, a BNP-type peptide, uric acid, Gal3 (Galectin-3), osteopontin, sST2 (soluble ST2), PlGF, sFlt-1, P1NP, Cystatin C, Prealbumin, and Transferrin in a sample from a subject suffering from heart failure. Further, the method comprises the step of comparing the, thus, determined amount with a reference amount. Further envisaged by the present invention are kits and devices adapted to carry out the method of the present invention.
    Type: Application
    Filed: June 4, 2015
    Publication date: September 24, 2015
    Inventors: Christian Zaugg, Dirk Block, Ursula-Henrike Wienhues-Thelen, Hans-Peter Brunner, Friedemann Krause, Fabian Model, Vincent Rolny
  • Patent number: 9017944
    Abstract: The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for predicting the disease free survival and/or response of a subject with a cell proliferative disorder of the breast tissues, to endocrine treatment.
    Type: Grant
    Filed: December 13, 2004
    Date of Patent: April 28, 2015
    Assignee: Epigenomics AG
    Inventors: John Foekens, Nadia Harbeck, Thomas Koenig, Sabine Maier, John W. Martens, Fabian Model, Inko Nimmrich, Manfred Schmitt, Ralf Lesche, Dimo Dietrich, Volkmar Mueller, Antje Kluth Lukas, Ina Schwope, Oliver Hartmann, Peter Adorjan, Almuth Marx, Heinz Hoefler
  • Publication number: 20150086989
    Abstract: Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: November 19, 2014
    Publication date: March 26, 2015
    Inventors: Juergen Distler, Thomas Hildmann, Ralf Lesche, Catherine Lofton-Day, Fabian Model, Matthias Schuster, Andrew Z. Sledziewski, Reimo Tetzner, Xiaoling Song
  • Patent number: 8900829
    Abstract: Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
    Type: Grant
    Filed: April 28, 2011
    Date of Patent: December 2, 2014
    Assignee: Epigenomics AG
    Inventors: Juergen Distler, Thomas Hildmann, Ralf Lesche, Catherine Lofton-Day, Fabian Model, Matthias Schuster, Andrew Z. Sledziewski, Reimo Tetzner, Xiaoling Song
  • Publication number: 20140227700
    Abstract: The invention provides methods, nucleic acids and kits for detecting prostate cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of said disorder, thereby enabling the improved diagnosis and treatment of patients.
    Type: Application
    Filed: April 28, 2014
    Publication date: August 14, 2014
    Applicant: EPIGENOMICS AG
    Inventors: Andrew Z. Sledziewski, Catherine E. Lofton-Day, Reimo Tetzner, Juergen Distler, Fabian Model, Shannon Payne, Dimo Dietrich
  • Publication number: 20140065610
    Abstract: An in vitro method of predicting whether a patient, having a neurodevelopmental, neurological or neuropsychiatric disorder, will derive a clinical benefit if treated with a glycine reuptake inhibitor (GRI), via determination of the protein concentration of one, two, three, four five or six members of the complement factor H family or a mixture or a combination thereof and comparison against a representative value, wherein a higher value of the protein concentration in the patient's sample against the representative value is indicative of a patient whom will derive clinical benefit from treatment with GRI.
    Type: Application
    Filed: August 21, 2012
    Publication date: March 6, 2014
    Inventors: Laurent Essioux, Carsten Horn, Johann Karl, Peter Kastner, Fabian Model, Giuseppe Palermo, Christina Rabe, Daniel Umbricht, Gabriel Vargas, Anne Vogt