Patents by Inventor Fabian Pfrengle

Fabian Pfrengle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNE CELL RECEPTOR ANTIBODIES CONJUGATED TO HIGH AFFINITY SIGLEC-LIGANDS
    Publication number: 20230037822
    Abstract: Described herein are Siglec ligand-antibody conjugates and compositions thereof that are useful for suppressing unwanted immune responses such as allergies and anaphylaxis.
    Type: Application
    Filed: October 28, 2020
    Publication date: February 9, 2023
    Applicant: The Scripps Research Institute
    Inventors: James C. Paulson, Maidul Islam, Fabian Pfrengle, Matthew Macauley, Shiteng Duan, Britni Arlian
  • Methods and Compositions for Treating Bleeding Disorders
    Publication number: 20160060324
    Abstract: The present invention provides immune conjugates for inducing antigen specific immune tolerance to coagulation Factor VIII. The immune conjugates contain a FVIII protein or antigenic fragment that is conjugated to a binding moiety for a sialic acid binding Ig-like lectin (Siglec) expressed on B cells. The invention also provides methods of using the FVIII immune conjugates to induce immune tolerance to FVIII in a subject. Additionally provided in the invention are methods for treating bleeding disorders such as hemophilia A via the use of the FVIII immune conjugates and an unconjugated FVIII with coagulating activity.
    Type: Application
    Filed: April 18, 2014
    Publication date: March 3, 2016
    Inventors: James C. Paulson, Matthew Macauley, Fabian Pfrengle