Abstract: Compositions and methods for urea silicone gels for treating skin conditions that may benefit from barrier protection and from urea silicone gel ability to return water balance to the skin are disclosed. Skin conditions that may be treated with urea silicone gel may be excessive dryness, insect bites, keloids and scars, among others. Disclosed urea silicone gel may include micronized urea USP, an anhydrous silicone base, and a PEG ointment base, among other ingredients. Anhydrous silicone base may include Amazonian oils such as pracaxi oil and seje oil, which are rich in oleic, linolenic, linoleic acids, and sterols, particularly beta-sitosterol and stigmasterol that may increase skin permeability to urea. PEG ointment base may be water-washable and includes meadowsweet extract. Additionally, PEG urea silicone gel may provide occlusion, and may maintain a moist environment within the skin condition which allows optimal healing. Pain also may be decreased by maintaining a moist environment.

Abstract: Compositions and methods for urea silicone gels for treating hyperkeratotic skin diseases that may benefit from barrier protection and from urea silicone gel's ability to return water balance to the skin are disclosed. Skin conditions that may be treated with urea silicone gels may be excessive dryness, callus, corns, old and new scars, and keloids, among others. Disclosed urea silicone gels may include micronized urea USP, and an anhydrous silicone base, among other ingredients. Anhydrous silicone base may include Amazonian oils such as pracaxi oil and seje oil, which are rich in oleic, linolenic, linoleic acids, and sterols, particularly beta-sitosterol and stigmasterol, which may increase skin permeability to urea. Additionally, because of the high content of unsaturated fatty acids of pracaxi oil and seje oil, disclosed urea silicone gel may exhibit an enhanced hydrating effect on skin cells, over-moisturizing and hydrating tough, thick hyperkeratotic conditions.

Abstract: The present disclosure describes a topical scar treatment composition that may include tamoxifen citrate in a concentration of about 0.01% by weight to about 1% by weight, with about 0.1% by weight being preferred, and an anhydrous silicone base for enhancing skin permeation and scar removing effects, in a concentration of about 10% by weight to about 100% by weight, with about 100% being preferred being preferred. The small concentration of tamoxifen citrate may prevent dangerous side effects and may be successful in treating abnormal scars such as keloids and hypertrophic scars.