Abstract: The invention concerns dihydroimidazo[5,1-a]-?-carboline compounds of general formula (I) wherein in particular, R1, R2, R3, R4, R6 and R7, identical or different, independently of one another, present a hydrogen, halogen atom, an alkyl, hydroxyl, alkoxy, trihalogenoalkyl, alkylamino, dialkylamino, aryl, arylalkyl, carboxy, alkylcarbonyloxy, acyl, aryloxy or arylalkoxy group; R5 represents a hydrogen atom, an alkyl or arylalkyl group; and their isomers as well as their addition salts to a pharmaceutically acceptable acid. The inventive compounds are for use in medicine, in particular as hypnotics.

Abstract: The invention concerns dihydroimi-dazo[5,1-a]-?-carboline compounds of general formula (1), wherein in particular, R1, R2, R2, Ra, R6 and K7, identical or different, independently of one another, represent a hydrogen, halogen atom, an alkyl, hydroxy, alkoxy, trihalogenoalkyl, alkylamino, dialkylamino, aryl, arylalkyl, carboxy, alkylcarbonyloxy, acyl, aryloxy or arylalkoxy group; R3 represents a hydrogen atom, an alkyl or arylalkoxy group; and their isomers as well as their addition salts to a pharmaceutically acceptable acid. The inventive compounds arm for use as medicine, in particular as hypnotic.

Abstract: The invention relates to pyrrolo[3,4-b]quinoline derivatives of general formula (I) wherein X represents an oxygen atom or a sulphur atom. Said derivatives have a hypnotic or sedative effect.

Abstract: Novel fluorinated derivatives of the vinblastine and vinorelbine family of general formula (1), ##STR1## wherein the symbols have the meanings indicated in the Specification and Claims, and the therapeutically-acceptable salts of these molecules, as well as pharmaceutical compositions thereof. The invention also concerns the application of said compounds in the treatment of a cancer pathology and their methods of preparation.