Patents by Inventor Fabienne Deguerry
Fabienne Deguerry has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230183761Abstract: Described herein are biocatalytic methods of producing terpene degradation products useful as starting material for the production of perfumery ingredients, such as, for example, ambrox. In particular novel terpene degrading polypeptides (enal-cleaving polypeptides) and novel peptides converting terpenes compounds to oxygenated derivatives (oxygenases) and mutants and variants derived therefrom are described which may be applied in novel types of fully enzymatic multistep degradation pathways allowing the controlled, stepwise conversion and degradation of linear or cyclic terpene substrates. Said novel biosynthetic strategies allow the fully biochemical synthesis of valuable terpene-derived compounds, like for example manooloxy or gamma ambrol. Also described herein are recombinant host organisms carrying the required set of genetic information for the functional expression of the set of enzymes necessary for catalyzing the combination of enzymatic conversion and degradation steps.Type: ApplicationFiled: July 8, 2020Publication date: June 15, 2023Inventors: Michel Schalk, Fabienne Deguerry, Daniel Solis Escalante, Pauline Anziani, Sabine Beccucci
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Publication number: 20230151393Abstract: Described herein are the nucleic acid and the amino acid sequences of a cytochrome P450 capable of oxidizing terpene molecules. Also described herein are methods of oxidizing terpene molecules including contacting the cytochrome P450 with the terpene molecule intended to be oxidized. In particular, the method may be carried out in vitro or in vivo to produce oxidized terpene molecules, which may be used in different technical fields such as for example perfumery and flavoring. Also described herein is an expression vector containing the nucleic acid. A non-human host organism or a cell transformed with the nucleic acid is also an object of the disclosure.Type: ApplicationFiled: January 16, 2019Publication date: May 18, 2023Inventors: Michel Schalk, Letizia Rocci, Fabienne Deguerry
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Patent number: 10385363Abstract: The present invention relates to a method of producing drimenol and/or drimenol derivatives by contacting at least one polypeptide with farnesyl diphosphate. The method may be performed in vitro or in vivo. The present invention also provides amino acid sequences of polypeptides useful in the method of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.Type: GrantFiled: May 6, 2015Date of Patent: August 20, 2019Assignee: Firmenich SAInventors: Yu-Hua Zhang, Michel Schalk, Olivier Haefliger, Xiu-Feng He, Fabienne Deguerry
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Patent number: 10337031Abstract: Provided herein is an isolated polypeptide from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis comprising a (+)-cedrol or a (?)-thujopsene synthase. Further provided herein is an isolated nucleic acid molecule from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis encoding a (+)-cedrol or (?)-thujopsene synthase. Further provided herein are methods of producing (+)-cedrol or (?)-thujopsene.Type: GrantFiled: April 11, 2016Date of Patent: July 2, 2019Assignee: Firmenich SAInventors: Michel Schalk, Fabienne Deguerry, Pan Li, Xiufeng He, Qi Wang
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Publication number: 20180251797Abstract: The present invention relates to a method of producing drimenol and/or drimenol derivatives by contacting at least one polypeptide with farnesyl diphosphate. The method may be performed in vitro or in vivo. The present invention also provides amino acid sequences of polypeptides useful in the method of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.Type: ApplicationFiled: May 6, 2015Publication date: September 6, 2018Applicant: Firmenich SAInventors: Yu-Hua ZHANG, Michel SCHALK, Olivier HAEFLIGER, Xiu-Feng HE, Fabienne DEGUERRY
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Patent number: 10000773Abstract: The present invention provides the nucleic acid and the amino acid sequences of a cytochrome P450 capable of oxidizing terpene molecules. It also provides a method of oxidizing terpene molecules comprising contacting the cytochrome P450 of the invention with the terpene molecule intended to be oxidized. In particular, said method may be carried out in vitro or in vivo to produce oxidized terpene molecules, which may be used in different technical fields such as for example perfumery and flavoring. The present invention also provides an expression vector containing the nucleic acid. A non-human host organism or a cell transformed with the nucleic acid is also an object of the invention.Type: GrantFiled: October 25, 2012Date of Patent: June 19, 2018Assignee: FIRMENICH SAInventors: Michel Schalk, Fabienne Deguerry
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Publication number: 20180094281Abstract: Provided herein is an isolated polypeptide from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis comprising a (+)-cedrol or a (?)-thujopsene synthase. Further provided herein is an isolated nucleic acid molecule from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis encoding a (+)-cedrol or (?)-thujopsene synthase. Further provided herein are methods of producing (+)-cedrol or (?)-thujopsene.Type: ApplicationFiled: April 11, 2016Publication date: April 5, 2018Applicant: Firmenich SAInventors: Michel SCHALK, Fabienne DEGUERRY, Pan LI, Xiufeng HE, Qi WANG
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Publication number: 20170283841Abstract: The present invention provides a method of producing patchoulol and 7-epi-?-selinene, said method comprising contacting at least one polypeptide with farnesyl phyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce patchoulol and 7-epi-?-selinene, compounds which can be useful in the field of perfumery. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing patchoulol and 7-epi-?-selinene is also an object of the present invention.Type: ApplicationFiled: June 12, 2017Publication date: October 5, 2017Applicant: FIRMENICH SAInventors: Michel SCHALK, Fabienne DEGUERRY
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Patent number: 9714440Abstract: The present invention provides a method of producing patchoulol and 7-epi-?-selinene, said method comprising contacting at least one polypeptide with famesyl phyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce patchoulol and 7-epi-?-seline, compounds which can be useful in the field of perfumery. The present invention also provides the amino acid sequence of polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing patchoul and 7-epi-?-selinene is also an object of the present invention.Type: GrantFiled: December 19, 2014Date of Patent: July 25, 2017Assignee: FIRMENICH SAInventors: Michel Schalk, Fabienne Deguerry
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Publication number: 20150218588Abstract: The present invention provides the nucleic acid and the amino acid sequences of a cytochrome P450 capable of oxidizing terpene molecules. It also provides a method of oxidizing terpene molecules comprising contacting the cytochrome P450 of the invention with the terpene molecule intended to be oxidized. In particular, said method may be carried out in vitro or in vivo to produce oxidized terpene molecules, which may be used in different technical fields such as for example perfumery and flavoring. The present invention also provides an expression vector containing the nucleic acid. A non-human host organism or a cell transformed with the nucleic acid is also an object of the invention.Type: ApplicationFiled: October 25, 2012Publication date: August 6, 2015Applicant: FIRMENICH SAInventors: Michel Schalk, Fabienne Deguerry
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Publication number: 20150099283Abstract: A method of producing patchoulol and 7-epi-?-selinene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). The method may be carried out in vitro or in vivo to produce patchoulol and 7-epi-?-selinene, compounds which can be useful in the field of perfumery.Type: ApplicationFiled: December 19, 2014Publication date: April 9, 2015Applicant: FIRMENICH SAInventors: Michel SCHALK, Fabienne DEGUERRY
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Patent number: 8927238Abstract: A method of producing patchoulol and 7-epi-?-selinene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). The method may be carried out in vitro or in vivo to produce patchoulol and 7-epi-?-selinene, compounds which can be useful in the field of perfumery.Type: GrantFiled: May 15, 2011Date of Patent: January 6, 2015Assignee: Firmenich SAInventors: Michel Schalk, Fabienne Deguerry
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Patent number: 8703454Abstract: A method of producing (+)-zizaene by contacting at least one polypeptide with farnesyl pyrophosphate (FPP) in vitro or in vivo to produce (+)-zizaene, a compound which can be used as precursor for diverse compounds useful in the fields of perfumery and flavoring. An amino acid sequence of a polypeptide useful in the method, a nucleic acid encoding the polypeptide of the invention, an expression vector containing the nucleic acid and a non-human host organism or a cell transformed to be used in the method of producing (+)-zizaene are also disclosed.Type: GrantFiled: May 12, 2010Date of Patent: April 22, 2014Assignee: Firmenich SAInventors: Michel Schalk, Fabienne Deguerry
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Publication number: 20130102038Abstract: A method of producing patchoulol and 7-epi-?-selinene by contacting at least one polypeptide with farnesyl phyrophosphate (fpp). The method may be carried out in vitro or in vivo to produce patchoulol and 7-epi-?-selinene, compounds which can be useful in the field of perfumery.Type: ApplicationFiled: May 5, 2011Publication date: April 25, 2013Applicant: FIRMENICH SAInventors: Michel Schalk, Fabienne Deguerry
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Publication number: 20120021475Abstract: A method of producing (+)-zizaene by contacting at least one polypeptide with farnesyl pyrophosphate (FPP) in vitro or in vivo to produce (+)-zizaene, a compound which can be used as precursor for diverse compounds useful in the fields of perfumery and flavoring. An amino acid sequence of a polypeptide useful in the method, a nucleic acid encoding the polypeptide of the invention, an expression vector containing the nucleic acid and a non-human host organism or a cell transformed to be used in the method of producing (+)-zizaene are also disclosed.Type: ApplicationFiled: May 12, 2010Publication date: January 26, 2012Applicant: FIRMENICH SAInventors: Michel Schalk, Fabienne Deguerry
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Patent number: 8058046Abstract: The invention relates to sesquiterpene synthases from Patchouli plants (Pogostemon cablin), and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthase. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of making and using these enzymes. For example, sesquiterpene synthases of the invention may be used to convert farnesyl-pyrophosphate to various sesquiterpenes including patchoulol, ?-curcumene and other germacrane-type sesquiterpenes.Type: GrantFiled: February 5, 2009Date of Patent: November 15, 2011Assignee: Firmenich SAInventors: Michel Schalk, Fabienne Deguerry
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Publication number: 20090205060Abstract: The invention relates to sesquiterpene synthases from Patchouli plants (Pogostemon cablin), and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for at least one sesquiterpene synthase. In a further embodiment, the invention also provides for sesquiterpene synthases and methods of making and using these enzymes. For example, sesquiterpene synthases of the invention may be used to convert farnesyl-pyrophosphate to various sesquiterpenes including patchoulol, ?-curcumene and other germacrane-type sesquiterpenes.Type: ApplicationFiled: February 5, 2009Publication date: August 13, 2009Inventors: Michel Schalk, Fabienne Deguerry