Patents by Inventor Fabio Cominelli

Fabio Cominelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12201082
    Abstract: One aspect of the present disclosure can include a multilayer static housing system for preventing the ingress of microorganisms therein. The housing system can include a static outer housing unit and at least one static inner housing unit nested completely inside of the outer housing unit. Airflow through the housing system can be driven passively by the chimney effect.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: January 21, 2025
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Alexander Rodriguez-Palacios, Fabio Cominelli
  • Patent number: 11667948
    Abstract: One aspect of the present disclosure can include a method for reducing or alleviating inflammation in the digestive tract of a subject in need thereof that consumes a disruptive dietary component. One step of the method can include assaying a previously obtained fecal sample from the subject for the presence of one or more Proteobacteria and an activity level of a peroxidase enzyme. The subject can decrease ingestion of the disruptive dietary component if the assayed presence of the one or more Proteobacteria and the activity level of the peroxidase enzyme are increased as compared to control levels.
    Type: Grant
    Filed: February 14, 2019
    Date of Patent: June 6, 2023
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Alexander Rodriguez-Palacios, Fabio Cominelli
  • Publication number: 20190249221
    Abstract: One aspect of the present disclosure can include a method for reducing or alleviating inflammation in the digestive tract of a subject in need thereof that consumes a disruptive dietary component. One step of the method can include assaying a previously obtained fecal sample from the subject for the presence of one or more Proteobacteria and an activity level of a peroxidase enzyme. The subject can decrease ingestion of the disruptive dietary component if the assayed presence of the one or more Proteobacteria and the activity level of the peroxidase enzyme are increased as compared to control levels.
    Type: Application
    Filed: February 14, 2019
    Publication date: August 15, 2019
    Inventors: Alexander Rodriguez-Palacios, Fabio Cominelli
  • Publication number: 20190216045
    Abstract: One aspect of the present disclosure can include a multilayer static housing system for preventing the ingress of microorganisms therein. The housing system can include a static outer housing unit and at least one static inner housing unit nested completely inside of the outer housing unit. Airflow through the housing system can be driven passively by the chimney effect.
    Type: Application
    Filed: January 17, 2019
    Publication date: July 18, 2019
    Inventors: Alexander Rodriguez-Palacios, Fabio Cominelli
  • Patent number: 5942390
    Abstract: A novel, differential association between allele 2 of the variable number of tandem repeats polymorphism at intron 2 of the human IL-1 receptor antagonist gene and ulcerative colitis in humans of Jewish ancestry has been discovered. In accordance with the present invention, there is provided methods of screening for ulcerative colitis in human subjects of Jewish ancestry comprising detecting the presence or absence of nucleic acid of the subject encoding allele 2 of the variable number of tandem repeats polymorphism at intron 2 of the human IL-1 receptor antagonist gene, wherein the presence of nucleic acid encoding allele 2 is indicative of ulcerative colitis. Kits useful for screening for ulcerative colitis in human subjects of Jewish ancestry are also provided.
    Type: Grant
    Filed: January 12, 1996
    Date of Patent: August 24, 1999
    Assignee: Cedars-Sinai Medical Center
    Inventors: Fabio Cominelli, Theresa Pizarro, Jerome I. Rotter, Huiying Yang