Patents by Inventor Fabio Giannessi

Fabio Giannessi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DERIVATIVES OF 4-TRIMETHYLAMMONIUM-3-AMINOBUTYRATE AND 4-TRIMETHYLPHOSPHONIUM-3-AMINOBUTYRATE AS CPT-INHIBITORS
    Publication number: 20090312286
    Abstract: The invention provides a new class of compounds capable of inhibiting carnitine palmitoyl transferase (CPT) having formula (I) The invention also relates to pharmaceutical compositions, which comprise at least one new compound according to the invention, and their therapeutic use in the treatment of hyperglycaemic conditions such as diabetes and the pathologies associated with it, such as for example congestive heart failure and obesity.
    Type: Application
    Filed: July 10, 2007
    Publication date: December 17, 2009
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Fabio Giannessi, Emanuela Tassoni, Natalina Dell' Uomo, Roberto Conti, Maria Ornella Tinti
  • Combination of antidiabetic drugs
    Publication number: 20090131515
    Abstract: The combination of R-4-trimethylammonio-3-(tetra-decylcarbamoyl)-aminobutyrate and metformin is disclosed. Said combination of anti-diabetic drugs exerts a synergic action and allows the administration of the two drugs at doses such as to avoid or reduce the occurrence of side effects. The combination is also useful for improving the therapeutic cover far from mealtimes, and in postabsorption and fasting conditions.
    Type: Application
    Filed: November 17, 2008
    Publication date: May 21, 2009
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.
    Inventors: Pompeo Pessoto, Fabio Giannessi
  • Derivatives of Aminobutanoic Acid Inhibiting Cpt
    Publication number: 20080161395
    Abstract: The invention relates to a new class of compounds with action inhibiting carnitine palmitoyl transferase (CPT), pharmaceutical compounds which contain at least one new compound according to the invention, and their therapeutic use in the treatment of hyperglycaemic conditions such as diabetes and the pathologies associated with it, congestive heart failure and obesity.
    Type: Application
    Filed: February 13, 2006
    Publication date: July 3, 2008
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Fabio Giannessi, Emanuela Tassoni, Maria Ornella Tinti, Roberto Conti, Natalina Dell'Uomo, Tiziana Brunetti
  • Use of ?-phenylthiocarboxylic and ?-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity
    Patent number: 7375124
    Abstract: The use is described of derivatives of ?-phenylthiocarboxylic and ?-phenyloxycarboxylic acids with formula (i): in which the substituents have the meanings described in the text, for the preparation of a medicine for the prophylaxis and treatment of diabetes, particularly type 2 diabetes, its complications, the various forms of insulin resistance, and hyperlipidaemias
    Type: Grant
    Filed: December 16, 2003
    Date of Patent: May 20, 2008
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Emanuela Tassoni, Maria Ornella Tinti, Pompeo Pessotto, Natalina Dell'Uomo, Anna Floriana Sciarroni, Tiziana Brunetti, Ferdinando Maria Milazzo
  • Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity
    Patent number: 7368605
    Abstract: Formula (I) compounds are described where the groups are as identified in the text, and their use as medicines, particularly as anti-diabetes, serum glucose-lowering and anti-obesity agents. They are useful for the prophylaxis and treatment of diabetes, particularly type 2 diabetes, and its complications, syndrome X, the various forms of insulin resistance, and hyperlipidaemias, as well as for the treatment of obesity.
    Type: Grant
    Filed: December 1, 2003
    Date of Patent: May 6, 2008
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Emanuela Tassoni, Maria Ornella Tinti, Pompeo Pessotto, Maurizio Botta, Pederico Corelli
  • Derivatives of alpha-phenylthiocarboxylic and alpha-phenyloxy-carboxylic acids useful for the treatment of diseases responding to PPARalpha activation
    Publication number: 20080027098
    Abstract: Formula (I) compounds are described in which the substituents have the meanings described in the text, and which are useful for the treatment of diseases responding to PPAR?activation, such as heart failure, the hyperlipaemias and atherosclerosis.
    Type: Application
    Filed: August 17, 2007
    Publication date: January 31, 2008
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.p.A.
    Inventors: Fabio Giannessi, Natalina Dell'Uomo, Emanuela Tassoni, Maria Tinti, Anna Sciarroni, Monica Bandera, Pompeo Pessotto, Arduino Arduini
  • Use of alpha-phenylthiocarboxylic and alpha-phenyloxycarboxylic acids with serum-glucose-lowering and serum-lipid-lowering activity
    Publication number: 20060154979
    Abstract: The use is described of derivatives of ?-phenylthiocarboxylic and ?-phenyloxycarboxylic acids with formula (i): in which the substituents have the meanings described in the text, for the preparation of a medicine for the prophylaxis and treatment of diabetes, particularly type 2 diabetes, its complications, the various forms of insulin resistance, and hyperlipidaemias.
    Type: Application
    Filed: December 16, 2003
    Publication date: July 13, 2006
    Inventors: Fabio Giannessi, Emanuela Tassoni, Maria Tinti, Pompeo Pessotto, Natalina Dell'Uomo, Anna Sciarroni, Tiziana Brunetti, Ferdinando Milazzo
  • Variously substituted derivatives of guanidine, and their use as medicines with anti-diabetes and/or anti-obesity activity
    Publication number: 20060069100
    Abstract: Formula (I) compounds are described where the groups are as identified in the text, and their use as medicines, particularly as anti-diabetes, serum glucose-lowering and anti-obesity agents. Said medicines are useful for the prophylaxis and treatment of diabetes, particularly type 2 diabetes, and its complications, syndrome X, the various forms of insulin resistance, and hyperlipidaemias, as well as for the treatment of obesity.
    Type: Application
    Filed: December 1, 2003
    Publication date: March 30, 2006
    Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Emanuela Tassoni, Maria Tinti, Pompeo Pessotto, Maurizio Botta, Pederico Corelli
  • Combination of antidiabetic drugs
    Publication number: 20060058385
    Abstract: The combination of R-4-trimethylammonio-3-(tetra-decylcarbamoyl)-aminobutyrate and metformin is disclosed. Said combination of anti-diabetic drugs exerts a synergic action and allows the administration of the two drugs at doses such as to avoid or reduce the occurrence of side effects. The combination is also useful for improving the therapeutic cover far from mealtimes, and in postabsorption and fasting conditions.
    Type: Application
    Filed: January 23, 2004
    Publication date: March 16, 2006
    Inventors: Fabio Giannessi, Pompeo Pessotto
  • Derivatives of alpha-phenylthiocarboxylic and $g(a)-phenyloxy-carboxylic acids useful for the treatment of diseases responding to pparalpha activation
    Publication number: 20050054671
    Abstract: Formula (I) compounds are described in which the substituents have the meanings described in the text, and which are useful for the treatment of diseases responding to PPAR? activation, such as heart failure, the hyperlipaemias and atherosclerosis.
    Type: Application
    Filed: January 15, 2003
    Publication date: March 10, 2005
    Inventors: Fabio Giannessi, Tassoni Emanuela, Dell'Uomo Natalina, Sciarroni Anna Floriana, Pessotto Pompeo, Arduini Arduino, Bandera Roma, Tinti Maria Ornella
  • Pheny (alkyl)carboxylic acid derivatives and dionic phenylalkylheterocyclic derivatives and their use as medicines with serum glucose and/or serum lipid lowering activity
    Publication number: 20050032787
    Abstract: Formula (I) compounds are described: Where the groups are as defined here below, and their use as medinies, particularly as serum glucose and serum lipid lowering agents. Said medicines are useful for the prophylaxis and treatment of diabetes, particularly type 2, and its complications, Syndrome X, the various forms of insulin resistance, and hyperlipidaemias, and present reduced side effects, and, particularly, reduced or no liver toxicity.
    Type: Application
    Filed: January 13, 2003
    Publication date: February 10, 2005
    Inventors: Fabio Giannessi, Tassoni Emanuela, Dell'Uomo Natalina, Brunetti Tiziana, Tinti Maria Ornella, Pessotto Pompeo, Arduini Arduino
  • Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
    Patent number: 6822115
    Abstract: R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives are prepared using starting from aspartic acid with the same configuration as the desired compounds. This process is advantageous from the industrial point of view in terms of the type of reactants used, the reduced volumes of solvents and the possibility of avoiding purification of the intermediate products.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: November 23, 2004
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Natalina Dell'uomo, Maria Ornella Tinti, Francesco De Angelis
  • Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
    Publication number: 20030153784
    Abstract: A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: 1
    Type: Application
    Filed: February 25, 2003
    Publication date: August 14, 2003
    Inventors: Fabio Giannessi, Natalina Dell'uomo, Maria Ornella Tinti, Francesco De Angelis
  • Synthesis of (R) and (S)-aminocarnitine, (R) and (S)-4-phosphonium-3-amino-butanoate, (R) and (S) 3,4-diaminobutanoic acid, and their derivatives starting from D- and L-aspartic acid
    Publication number: 20030153783
    Abstract: A process is described for the preparation of R or S aminocarnitine, R or S phosphonium aminocarnitine and R and S 3,4 diaminobutanoic acid, and their derivatives with the following formula: 1
    Type: Application
    Filed: January 8, 2003
    Publication date: August 14, 2003
    Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Natalina Dell'Uomo, Maria Ornella Tinti, Francesco De Angelis
  • Synthesis of (R) and (S) -aminocarnitine and their derivatives starting from D- and L-aspartic acid
    Patent number: 6528684
    Abstract: R or S aminocarnitine and their derivatives with formula (I) where Y is as described in the description, starting with aspartic acid with the same configuration as the aminocarnitine desired. This process has advantage in the type of reactants used, reduced volumes of solvents and the possibility of avoiding purification of intermediate products.
    Type: Grant
    Filed: December 21, 2001
    Date of Patent: March 4, 2003
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Natalina Dell'uomo, Maria Ornella Tinti, Francesco De Angelis
  • Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase
    Patent number: 6444701
    Abstract: Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine palmitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.
    Type: Grant
    Filed: November 8, 2001
    Date of Patent: September 3, 2002
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Mauro Marzi, Patrizia Minetti, Francesco De Angelis, Maria Ornella Tinti, Piero Chiodi, Arduino Arduini
  • Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase
    Publication number: 20020052348
    Abstract: Compounds of formula (I) 1
    Type: Application
    Filed: November 8, 2001
    Publication date: May 2, 2002
    Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Mauro Marzi, Patrizia Minetti, Francesco De Angelis, Maria Ornella Tinti, Piero Chiodi, Arduino Arduini
  • Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase
    Patent number: 6369073
    Abstract: Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine palmitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.
    Type: Grant
    Filed: October 2, 2000
    Date of Patent: April 9, 2002
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Mauro Marzi, Patrizia Minetti, Francesco De Angelis, Maria Ornella Tinti, Piero Chiodi, Arduino Arduini
  • Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase
    Patent number: RE40861
    Abstract: Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine palmitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: July 21, 2009
    Assignee: Sigma-Tau Industrie Farmaceutiche Reunite S.p.A.
    Inventors: Fabio Giannessi, Mauro Marzi, Patrizia Minetti, Francesco De Angelis, Maria O. Tinti, Piero Chiodi, Arduino Arduini
  • Compounds having reversible inhibiting activity of carnitine palmitoyl-transferase
    Patent number: RE41226
    Abstract: Compounds of formula (I) wherein the groups are as defined in the description are disclosed. The compounds of formula (I) are endowed with reversible inhibiting activity of carnitine palmitoyl-transferase and are useful in the preparation of medicaments useful in the pathologies related to a hyperactivity of carnitine polymitoyl-transferase, such as hyperglycemia, diabetes and pathologies related thereto, heart failure, ischemia.
    Type: Grant
    Filed: December 1, 2006
    Date of Patent: April 13, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Fabio Giannessi, Mauro Marzi, Patrizia Minetti, Francesco De Angelis, Maria Ornella Tinti, Piero Chiodi, Arduino Arduini