Abstract: A process for the production of yttrium-90, generated by radioactive decay of strontium-90, by means of a generator including a column containing strontium-90 adsorbed on a cation-exchange resin, wherein yttrium-90, the decay product of strontium-90, is obtained by the flow of an eluent through the resin column of the generator, an acetate buffer solution being used as the eluent. The process enables a solution to be obtained which is usable directly for labelling protein substrates, particularly monoclonal antibodies, with yttrium-90.

Abstract: The peptides described are modified with the phosphine group and are useful for marking with .sup.99m Tc and .sup.186-188 Re or paramagnetic agents for use in diagnosis and radiotherapy; in particular chelating compounds having the co-ordinating sets PN.sub.2 X, where X is --S, --O, COO--, PN.sub.3, P.sub.2 N.sub.3 and P.sub.2 N.sub.2 are described.

Abstract: A device or kit having inlet means for introducing within the kit a first reagent, includes a substrate and at least a second reagent in the form of microcapsules adapted to release, according to a predetermined release profile, the second reagent after the first reagent has been introduced into the kit. The device allows to carry out at least two and optionally more transformations of the physical and/or chemical properties of the substrate by means of a single step procedure by the operator consisting of the introduction of the first reagent.The invention particularly relates to the preparation of stable injectable preparations of radiopharmaceuticals.