Abstract: Provided herein are compositions and methods of reducing certain psychoactive and physiological effects of tetrahydrocannabinol (THC), some of which may be undesirable, while preserving beneficial effects of cannabis in a human in need thereof. The methods described involve administration of therapeutically effective amounts of guineensine. Also, provided are compositions wherein guineensine is part of an herbal composition and is formulated for sublingual delivery.

Abstract: The invention relates to engineered, humanized antibodies that have high binding affinity for and neutralize human IL-21, methods of using the antibodies to treat conditions in which antagonism or neutralization of the effects of IL-21 is warranted, such as autoimmune conditions, compositions and methods for recombinantly producing the antibodies, and pharmaceutical compositions comprising the antibodies.

Abstract: The invention relates to engineered, humanized antibodies that have high binding affinity for and neutralize human IL-21, methods of using the antibodies to treat conditions in which antagonism or neutralization of the effects of IL-21 is warranted, such as autoimmune conditions, compositions and methods for recombinantly producing the antibodies, and pharmaceutical compositions comprising the antibodies.

Abstract: Treatment of rheumatoid arthritis (RA) to provide clinical benefit in patients, including decrease in DAS28-CRP by more than 1.2 and/or improvement determined by ACR20, ACR50 or ACR70, comprising administering therapeutic antibody mavrilimumab or other inhibitor targeted to Tyr-Leu-Asp-Phe-Gln motif of granulocyte/macrophage colony stimulating factor receptor alpha (GM-CSFR?). Use of GM-CSFR? inhibitors such as mavrilimumab to enhance clinical benefit in RA patients receiving stable dose of DMARDs, particularly methotrexate.

Abstract: A new and improved pigtail type catheter and method particularly suited for the local thermodilution technique for determination of venous blood flow. The fluid injection aperture is disposed in the pigtail portion adjacent the most forward extending area thereof. A thermister is operably associated with the pigtail portion adjacent the distal end thereof intermediate the spaced apart side edges. A separate aperture may be conveniently included at the distal end of the pigtail portion to facilitate pressure readings of the venous flow. The new structural arrangement and method facilitate absolute thermal insulation between the fluid injected into the venous flow and the thermister, avoidance of contact between the thermister and vessel walls and a generally constant spacial relationship between the injection aperture and thermister.