Patents by Inventor Fabio Parmeggiani

Fabio Parmeggiani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12077801
    Abstract: The present invention relates to novel process for the production of ketoisophorone via biocatalytic conversion of isophorone, in particular a one-pot biocatalytic system for conversion of ?-isophorone in a two-step oxidation process, with a first oxidation being catalyzed by a heme containing oxidoreductase such as a cytochrome P450 monooxygenase followed by another oxidation which can be either a chemical reaction or a biocatalytic reaction, in particular wherein the oxidation is catalyzed by an NAD(P) or NADP(H)-dependent oxidoreductase. The invention further provides polypeptides and nucleic acid sequences coding for cytochrome P450 monooxygenase with modified (higher) substrate selectivity, total turnover numbers and/or (re)activity compared to the wild-type enzyme. Ketoisophorone is useful as building block in the synthesis of vitamins and carotenoids.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: September 3, 2024
    Assignee: DSM IP ASSETS B.V.
    Inventors: Werner Bonrath, Martin Schürmann, Michele Tavanti, Fabio Parmeggiani, Nicholas Turner, Andrea Mattevi, Jose Ruben Casstellanos
  • Publication number: 20230272446
    Abstract: Methods and systems for designing proteins are disclosed, as well as proteins and protein assemblies designed. A computing device can determine a protein repeating unit that includes one or more protein helices and one or more protein loops. The computing device can generate a protein backbone structure with a copy of the protein repeating unit. The computing device can determine whether a distance between a pair of helices of the protein backbone structure is between lower and upper distance thresholds. After determining that the distance between the pair of helices is between the lower and upper distance thresholds, the computing device can: generate a plurality of protein sequences based on the protein backbone structure, select a particular protein sequence of the plurality of protein sequences based on an energy landscape that has information about energy and distance from a target fold of the particular protein sequence, and generate an output based on the particular protein sequence.
    Type: Application
    Filed: May 5, 2023
    Publication date: August 31, 2023
    Inventors: Fabio PARMEGGIANI, TJ BRUNETTE, Po-Ssu HUANG, David BAKER
  • Publication number: 20210108234
    Abstract: The present invention relates to novel process for the production of ketoisophorone via biocatalytic conversion of isophorone, in particular a one-pot biocatalytic system for conversion of ?-isophorone in a two-step oxidation process, with a first oxidation being catalyzed by a heme containing oxidoreductase such as a cytochrome P450 monooxygenase followed by another oxidation which can be either a chemical reaction or a biocatalytic reaction, in particular wherein the oxidation is catalyzed by an NAD(P) or NADP(H)-dependent oxidoreductase. The invention further provides polypeptides and nucleic acid sequences coding for cytochrome P450 monooxygenase with modified (higher) substrate selectivity, total turnover numbers and/or (re)activity compared to the wild-type enzyme. Ketoisophorone is useful as building block in the synthesis of vitamins and carotenoids.
    Type: Application
    Filed: April 6, 2018
    Publication date: April 15, 2021
    Inventors: Werner BONRATH, Martin SCHÜRMANN, Michele TAVANTI, Fabio PARMEGGIANI, Nicholas TURNER, Andrea MATTEVI, Jose Ruben CASSTELLANOS
  • Publication number: 20190012428
    Abstract: Methods and systems for designing proteins are disclosed, as well as proteins and protein assemblies designed. A comparing device can determine a protein repeating unit that includes one or more protein helices and one or more protein loops. The computing device can generate a protein backbone structure with a copy of the protein repeating unit. The computing device can determine whether a distance between a pair of helices of the protein backbone structure is between lower and upper distance thresholds. After determining that the distance between the pair of helices is between the lower and upper distance thresholds, the computing device can generate a plurality of protein sequences based on the protein backbone structure, select a particular protein sequence of the plurality of protein sequences based on an energy landscape that has information about energy and distance from a target fold of the particular protein sequence, and generate an output based on the particular protein sequence.
    Type: Application
    Filed: December 16, 2016
    Publication date: January 10, 2019
    Inventors: Fabio PARMEGGIANI, TJ BRUNETTE, Po-Ssu HUANG, David BAKER
  • Patent number: 9365629
    Abstract: The invention relates to collections of target-specific designed binding proteins based on armadillo repeat proteins, and to a method of generating them. Designed armadillo repeat proteins are based on consensus sequences of single armadillo repeat units. These repeat proteins can be used as scaffolds for peptide recognition. Such a scaffold provides a binding mode that is in principle the same for every small recognizable unit, e.g. an amino acid or dipeptide, allowing a precise and modular recognition of a peptide in extended conformation. The method allows to generate a series of modules recognizing these simple units, and to combine such building blocks to create a binding site for any desired peptide target without performing additional selections.
    Type: Grant
    Filed: September 23, 2008
    Date of Patent: June 14, 2016
    Assignee: University of Zurich
    Inventors: Fabio Parmeggiani, Riccardo Pellarin, Anders Peter Larsen, Gautham Varadamsetty, Michael Tobias Stumpp, Andreas Plückthun
  • Publication number: 20110224100
    Abstract: The invention relates to collections of target-specific designed binding proteins based on armadillo repeat proteins, and to a method of generating them. Designed armadillo repeat proteins are based on consensus sequences of single armadillo repeat units. These repeat proteins can be used as scaffolds for peptide recognition. Such a scaffold provides a binding mode that is in principle the same for every small recognizable unit, e.g. an amino acid or dipeptide, allowing a precise and modular recognition of a peptide in extended conformation. The method allows to generate a series of modules recognizing these simple units, and to combine such building blocks to create a binding site for any desired peptide target without performing additional selections.
    Type: Application
    Filed: September 21, 2008
    Publication date: September 15, 2011
    Inventors: Fabio Parmeggiani, Riccardo Pellarin, Anders Peter Larsen, Gautham Varadamsetty, Michael Tobias Stumpp, Andreas Plückthun