Patents by Inventor Fabrice Cornille

Fabrice Cornille has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
    Patent number: 10125164
    Abstract: The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: November 13, 2018
    Assignee: FLAMMA S.P.A.
    Inventors: Xinjun Zhao, Minyu Zheng, Xiaozhong Yu, Hanrong Gao, Fabrice Cornille
  • Process for the production of D-arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide
    Patent number: 10112976
    Abstract: The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: October 30, 2018
    Assignee: FLAMMA S.P.A.
    Inventors: Xinjun Zhao, Minyu Zheng, Xiaozhong Yu, Hanrong Gao, Fabrice Cornille
  • PROCESS FOR THE PRODUCTION OF D-ARGINYL-2,6-DIMETHYL-L-TYROSYL-L-LYSYL-L-PHENYLALANINAMIDE
    Publication number: 20170152289
    Abstract: The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.
    Type: Application
    Filed: June 24, 2015
    Publication date: June 1, 2017
    Inventors: Xinjun Zhao, Minyu Zheng, Xiaozhong Yu, Hanrong Gao, Fabrice Cornille
  • Process for Preparing D-Arginyl-2,6-Dimethyl-L-Tyrosyl-L-Lysyl-L-Phenylalaninamide
    Publication number: 20170129920
    Abstract: The invention relates to a process for solution-phase synthesis of D-Arginyl-2,6-dimethyl-L-tyrosyl-L-lysyl-L-phenylalaninamide, an active ingredient used for both common and rare diseases including a mitochondrial targeted therapy for ischemia reperfusion injury.
    Type: Application
    Filed: June 24, 2015
    Publication date: May 11, 2017
    Inventors: Xinjun Zhao, Minyu Zheng, Xiaozhong Yu, Hanrong Gao, Fabrice Cornille
  • Process for the preparation of N-carboxyanhydrides
    Patent number: 6603016
    Abstract: The invention relates to an improved process for the preparation of N-carboxyanhydrides by reaction of the corresponding amino acid or one of its salts with phosgene, diphosgene and/or triphosgene in a solvent medium, characterized in that at least a portion of the reaction is carried out under a pressure of less than 1000 mbar. The N-carboxyanhydrides are thus obtained with better yields and an improved purity.
    Type: Grant
    Filed: May 30, 2002
    Date of Patent: August 5, 2003
    Assignee: Isochem
    Inventors: Fabrice Cornille, Marc Lebon
  • Process for the preparation of N-carboxyanhydrides
    Publication number: 20020183551
    Abstract: The invention relates to an improved process for the preparation of N-carboxyanhydrides by reaction of the corresponding amino acid or one of its salts with phosgene, diphosgene and/or triphosgene in a solvent medium, characterized in that at least a portion of the reaction is carried out under a pressure of less than 1000 mbar. The N-carboxyanhydrides are thus obtained with better yields and an improved purity.
    Type: Application
    Filed: May 30, 2002
    Publication date: December 5, 2002
    Inventors: Fabrice Cornille, Marc Lebon
  • Process for the preparation of N-carboxyanhydrides
    Patent number: 6479665
    Abstract: The invention relates to a process for the preparation of N-carboxyanhydrides by reaction of the corresponding amino acid with phosgene, diphosgene and/or triphosgene in a solvent medium, characterized in that the reaction is a least partially carried out in the presence of an unsaturated organic compound which has one or more ethylenic double bonds, one of the carbon of at least one ethylenic double bond of which is completely substituted by substituents other than halogen atoms. The N-carboxyanhydrides are thus obtained with better yields and an improved purity.
    Type: Grant
    Filed: October 29, 2001
    Date of Patent: November 12, 2002
    Assignee: Isochem
    Inventors: Fabrice Cornille, Jean-Luc Copier, Jean-Pierre Senet, Yves Robin
  • Process for the preparation of N-carboxyanhydrides
    Publication number: 20020082431
    Abstract: The invention relates to a process for the preparation of N-carboxyanhydrides by reaction of the corresponding amino acid with phosgene, diphosgene and/or triphosgene in a solvent medium, characterized in that the reaction is a least partially carried out in the presence of an unsaturated organic compound which has one or more ethylenic double bonds, one of the carbon of at least one ethylenic double bond of which is completely substituted by substituents other than halogen atoms.
    Type: Application
    Filed: October 29, 2001
    Publication date: June 27, 2002
    Inventors: Fabrice Cornille, Jean-Luc Copier, Jean-Pierre Senet, Yves Robin