Patents by Inventor Fabrice Duprat

Fabrice Duprat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MECHANOSENSITIVE MAMMALIAN POTASSIUM CHANNEL ACTIVATABLE BY POLYUNSATURATED FATTY ACIDS
    Publication number: 20090162368
    Abstract: A purified protein comprising a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of said channels in drug screening.
    Type: Application
    Filed: December 5, 2008
    Publication date: June 25, 2009
    Applicant: Centre National de la Recherche Scientifique-CNRS, corporation of France
    Inventors: Eric Honore, Michel Fink, Michel Lazdunski, Florian Lesage, Fabrice Duprat
  • Mechanosensitive mammalian potassium channel activatable by polyunsaturated fatty acids
    Patent number: 7468422
    Abstract: A purified protein including a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of channels in drug screening.
    Type: Grant
    Filed: September 12, 2005
    Date of Patent: December 23, 2008
    Assignee: Centre National de la Recherche Scientifique - CNRS
    Inventors: Eric Honore, Michel Fink, Michel Lazdunski, Florian Lesage, Fabrice Duprat
  • Method for the identification of anesthetics
    Patent number: 7112403
    Abstract: Human and mouse TREK-1 potassium transport proteins are disclosed as well a method for using potassium transport proteins for identifying substances having anesthetic properties, such as producing a safe, reversible state of unconsciousness with concurrent amnesia and analgesia in a mammal upon inhalation, in a method comprising (a) contacting the test substance with a mammalian potassium transport protein, wherein said potassium transport protein exhibits outward-going potassium rectification; and (b) determining the potassium transport activity of the potassium transport protein, wherein an activation of potassium transport is indicative of the test substance having anesthetic properties.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: September 26, 2006
    Assignees: Centre National de la Recherche Scientifique, CNRS and Fabrice Duprat
    Inventors: Amanda J. Patel, Eric Honore, Florian Lesage, Georges Romey, Michel Lazdunski, Michel Fink, Fabrice Duprat, Francois Maingret
  • Isolated TWIK-1 potassium channel proteins
    Patent number: 7067625
    Abstract: This invention relates to the cloning of a member of a new potassium channel named TWIK-1. More specifically, it relates to an isolated and purified nucleic acid molecule coding for a protein constituting a potassium channel exhibiting the proper-ties and structure of the TWIK-1 type channel, as well as the protein coded by this nucleic acid molecule. The invention also relates to the use of this nucleic acid molecule to transform cells, and the use of these cells expressing the potassium channels exhibiting the properties and structure of the TWIK-1 type channel for the screening of drugs.
    Type: Grant
    Filed: January 11, 2000
    Date of Patent: June 27, 2006
    Inventors: Florian Lesage, Eric Guillemare, Michel Fink, Fabrice Duprat, Michel Lazdunski, Georges Romey, Jacques Barhanin
  • Mechanosensitive mammalian potassium channels activatable by polyunsaturated fatty acids and the use of said channels in drug screening
    Publication number: 20060024729
    Abstract: A purified protein comprising a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of said channels in drug screening.
    Type: Application
    Filed: September 12, 2005
    Publication date: February 2, 2006
    Applicant: Centre National de la Recherche Scientifique - CNRS, corporation of France
    Inventors: Eric Honore, Michel Fink, Michel Lazdunski, Florian Lesage, Fabrice Duprat
  • Method for screening substances capable of modulating the activity of a TRAAK potassium channel
    Patent number: 6942979
    Abstract: A purified protein comprising a mechanosensitive potassium channel activated by at least one polyunsaturated fatty acid and riluzole and the use of such channels in drug screening.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: September 13, 2005
    Assignee: Centre National de la Recherche Scientifique-CNRS
    Inventors: Eric Honore, Michel Fink, Michel Lazdunski, Florian Lesage, Fabrice Duprat
  • Family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs
    Publication number: 20020094558
    Abstract: This invention relates to a new member of a recently recognized TWIK potassium + channel family, herein identified as TASK. For TWIK-related acid-sensitive K + channel. This is the first cloned mammalian channel that produces K+ currents that possesses all the characteristics of background conductances. The inventions also relates to various constructs including the TASK or related human potassium channel family, and their uses.
    Type: Application
    Filed: August 24, 2001
    Publication date: July 18, 2002
    Applicant: Centre National De La Recherche Scientifique-CNRS
    Inventors: Fabrice Duprat, Florian Lesage, Michel Fink, Michel Lazdunski
  • Family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs
    Publication number: 20020032322
    Abstract: This invention relates to a new member of a recently recognized TWIK potassium+ channel family, herein identified as TASK. For TWIK-related acid-sensitive K+ channel. This is the first cloned mammalian channel that produces K+ currents that possesses all the characteristics of background conductances The inventions also relates to various constructs including the TASK or related human potassium channel family, and their uses.
    Type: Application
    Filed: August 24, 2001
    Publication date: March 14, 2002
    Applicant: Centre National De La Recherche Scientifique-CNRS
    Inventors: Fabrice Duprat, Florian Lesage, Michel Fink, Michel Lazdunski
  • Family of mammalian potassium channels, their cloning and their use, especially for the screening of drugs
    Patent number: 6309855
    Abstract: This invention relates to a new member of a recently recognized TWIK potassium+channel family, herein identified as TASK, for TWIK-related acid-sensitive K+ channel. This is the first cloned mammalian channel that produces K+ currents that possesses all the characteristics of background conductances. The invention also relates to various constructs including the TASK or related human potassium channel family, and their uses.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: October 30, 2001
    Assignee: Centre National de la Recherche (CNRS)
    Inventors: Fabrice Duprat, Florian Lesage, Michel Fink, Michel Lazdunski
  • Family of mammalian potassium channels, their cloning and their use especially for the screening of drugs
    Patent number: 6013470
    Abstract: The present invention relates to the cloning of a member of a new potassium channel named TWIK-1. More specifically, it relates to an isolated and purified nucleic acid molecule coding for a protein constituting a potassium channel exhibiting the properties and structure of the TWIK-1 type channel, as well as the protein coded by this nucleic acid molecule.The invention also relates to the use of this nucleic acid molecule to transform cells, and the use of these cells expressing the potassium channels exhibiting the properties and structure of the TWIK-1 type channel for the screening of drugs.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: January 11, 2000
    Assignee: Centre National de la Recherche Scientifique-CNRS
    Inventors: Florian Lesage, Eric Guillemare, Michel Fink, Fabrice Duprat, Michel Lazdunski, Georges Romey, Jacques Barhanin