Patents by Inventor Fabrice Gallou

Fabrice Gallou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE MANUFACTURE OF 1,4-DISUBSTITUTED PYRIDAZINE COMPOUNDS
    Publication number: 20230348420
    Abstract: The invention relates to a novel process, novel process step(s) and novel intermediate(s) useful for the preparation of 1,4-disubstituted pyridazine compounds, such as 5-(1H-Pyrazol-4-yl)-2-(6-((2,2,6,6-tetramethylpiperidin-4-yl)oxy)pyridazin-3-yl)phenol.
    Type: Application
    Filed: June 24, 2021
    Publication date: November 2, 2023
    Inventors: Nicolas AMIOT, Darija DEDIC, Peng FU, Fabrice GALLOU, Xingxian GU, Cornelius HARLACHER, Siqian LIU, Shuping YAO, Jiong YE, Jianguang ZHOU
  • SURFACTANT SYSTEMS FOR CRYSTALLIZATION OF ORGANIC COMPOUNDS
    Publication number: 20220274966
    Abstract: The present invention is directed to methods for producing crystals or aggregates of organic compounds using a composition comprising a surfactant-water mixture, the organic compound and optionally an organic solvent as starting composition. This surfactant system enables the production of a high variety of different crystals and aggregates. The method is in particular suitable for obtaining crystals and aggregates optimized for isolation and purification during chemical synthesis processes.
    Type: Application
    Filed: May 13, 2022
    Publication date: September 1, 2022
    Inventors: Fabrice GALLOU, Michael PARMENTIER
  • Catalysts for chemical reactions in a water-surfactant mixture
    Patent number: 11235316
    Abstract: The present invention is directed to reaction mixtures comprising a water-surfactant mixture, wherein the catalyst comprises a compound with solubilizing groups. This technology improves the solubility of the reaction components in the water-surfactant mixture and thereby, greatly increases the productivity and selectivity of the chemical reaction.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: February 1, 2022
    Assignee: Novartis AG
    Inventors: Fabrice Gallou, Pengfei Guo, Jianguang Zhou, Michael Parmentier
  • Reaction medium containing water-surfactant mixture
    Patent number: 11236076
    Abstract: The present invention is directed to reaction mixtures comprising a water-surfactant mixture and a co-solvent. This technology reduced the amount of organic solvents needed for performing chemical reactions. Furthermore, compared to reaction mixtures lacking the co-solvent, solvation of the reactants and products of the chemical reaction is greatly enhanced, leading to a significantly improved yield, purity, reproducibility and robustness.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: February 1, 2022
    Assignee: Novartis AG
    Inventors: Fabrice Gallou, Michael Parmentier, Jianguang Zhou, Pengfei Guo
  • Enzymatic reaction medium containing surfactant
    Patent number: 11220681
    Abstract: The present invention is directed to aqueous reaction mixtures for enzymatic synthesis reactions comprising a surfactant. The surfactant in the reaction mixture increases stability and yield of the enzymatic reaction. Furthermore, method for performing an enzymatic reaction using said aqueous reaction mixtures are provided.
    Type: Grant
    Filed: January 11, 2018
    Date of Patent: January 11, 2022
    Assignee: NOVARTIS AG
    Inventors: Yu Gai, Fabrice Gallou, Feng Gao, Pengfei Guo, Weiyong Kong, Michael Parmentier, Jianguang Zhou
  • Chemical Process for Preparing Imidazopyrrolidinone Derivatives and Intermediates Thereof
    Publication number: 20210087194
    Abstract: The present disclosure relates to a method of synthesizing imidazopyrrolidinone derivative, such as compound of formula (I), or a solvate including hydrate thereof, or a co-crystal thereof, and/or intermediates thereof, their use as pharmaceuticals and the use of intermediates.
    Type: Application
    Filed: September 1, 2020
    Publication date: March 25, 2021
    Inventors: Hao Wang, Jiong Ye, Bo Han, Dietmar Flubacher, Hans Stettler, Fabrice Gallou, Franck Mallet, Matthias Napp, Michael Haller
  • REACTION MEDIUM CONTAINING WATER-SURFACTANT MIXTURE
    Publication number: 20200299281
    Abstract: The present invention is directed to reaction mixtures comprising a water-surfactant mixture and a co-solvent. This technology reduced the amount of organic solvents needed for performing chemical reactions. Furthermore, compared to reaction mixtures lacking the co-solvent, solvation of the reactants and products of the chemical reaction is greatly enhanced, leading to a significantly improved yield, purity, reproducibility and robustness.
    Type: Application
    Filed: March 27, 2017
    Publication date: September 24, 2020
    Inventors: Fabrice Gallou, Michael PARMENTIER, Jianguang ZHOU, Pengfei GUO
  • Process for preparing 1-(4-methanesulfonyl-2-trifluoromethyl-benzyl)-2-methyl-1H-pyrrolo [2,3-B]pyridin-3-yl-acetic acid
    Patent number: 10723735
    Abstract: This invention relates to novel processes for synthesizing [1-(4-Methanesulfonyl-2-trifluoromethyl-benzyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acid and to intermediates that are used in such processes.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: July 28, 2020
    Inventors: Fabrice Gallou, Philipp Lustenberger, Christian Mathes, Qiangbiao Pan, Benli Zou
  • PROCESS FOR PREPARING 1-(4-METHANESULFONYL-2-TRIFLUOROMETHYL-BENZYL)-2-METHYL-1H-PYRROLO [2,3-B]PYRIDIN-3-YL-ACETIC ACID
    Publication number: 20200031824
    Abstract: This invention relates to novel processes for synthesizing [1-(4-Methanesulfonyl-2-trifluoromethyl-benzyl)-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl]-acetic acid and to intermediates that are used in such processes.
    Type: Application
    Filed: March 29, 2018
    Publication date: January 30, 2020
    Inventors: Fabrice Gallou, Philipp Lustenberger, Christian Mathes, Qiangbiao Pan, Benli Zou
  • SURFACTANT SYSTEMS FOR CRYSTALLIZATION OF ORGANIC COMPOUNDS
    Publication number: 20200017482
    Abstract: The present invention is directed to methods for producing crystals or aggregates of organic compounds using a composition comprising a surfactant-water mixture, the organic compound and optionally an organic solvent as starting composition. This surfactant system enables the production of a high variety of different crystals and aggregates. The method is in particular suitable for obtaining crystals and aggregates optimized for isolation and purification during chemical synthesis processes.
    Type: Application
    Filed: September 26, 2017
    Publication date: January 16, 2020
    Inventors: Fabrice GALLOU, Michael PARMENTIER
  • ENZYMATIC REACTION MEDIUM CONTAINING SURFACTANT
    Publication number: 20190367900
    Abstract: The present invention is directed to aqueous reaction mixtures for enzymatic synthesis reactions comprising a surfactant. The surfactant in the reaction mixture increases stability and yield of the enzymatic reaction. Furthermore, method for performing an enzymatic reaction using said aqueous reaction mixtures are provided.
    Type: Application
    Filed: January 11, 2018
    Publication date: December 5, 2019
    Inventors: Yu GAI, Fabrice GALLOU, Feng GAO, Pengfei GUO, Weiyong KONG, Michael PARMENTIER, Jianguang ZHOU
  • Chemical Process for Preparing Imidazopyrrolidinone Derivatives and Intermediates Thereof
    Publication number: 20190337952
    Abstract: The present disclosure relates to a method of synthesizing imidazopyrrolidi-none derivative, such as compound of formula (I), or a solvate including hydrate thereof, or a co-crystal thereof, and/or intermediates thereof, their use as pharmaceuticals and the use of intermediates.
    Type: Application
    Filed: November 20, 2017
    Publication date: November 7, 2019
    Inventors: Hao Wang, Jiong Ye, Bo Han, Dietmar Flubacher, Hans Stettler, Fabrice Gallou, Franck Mallet, Matthias Napp, Michael Haller
  • CATALYSTS FOR CHEMICAL REACTIONS IN A WATER-SURFACTANT MIXTURE
    Publication number: 20190308180
    Abstract: The present invention is directed to reaction mixtures comprising a water-surfactant mixture, wherein the catalyst comprises a compound with solubilizing groups. This technology improves the solubility of the reaction components in the water-surfactant mixture and thereby, greatly increases the productivity and selectivity of the chemical reaction.
    Type: Application
    Filed: July 10, 2017
    Publication date: October 10, 2019
    Inventors: Fabrice GALLOU, Pengfei GUO, Jianguang ZHOU, Michael PARMENTiER
  • Process for the manufacture of cyclic undecapeptides
    Patent number: 9840534
    Abstract: The present invention relates to processes and intermediates useful for the manufacture of cyclic undecapeptides, such as Alisporivir.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: December 12, 2017
    Assignee: Novartis AG
    Inventors: Fabrice Gallou, Bernard Riss
  • Process for Preparing N-(4-Cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic Acid Ethyl Ester
    Publication number: 20170166517
    Abstract: This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I below and other intermediates that are used in such processes.
    Type: Application
    Filed: February 14, 2017
    Publication date: June 15, 2017
    Applicant: Novartis AG
    Inventors: Fabrice GALLOU, Joerg Matthias SEDELMEIER, Caspar VOGEL
  • Process for preparing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester
    Patent number: 9604914
    Abstract: This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I below and other intermediates that are used in such processes.
    Type: Grant
    Filed: February 1, 2013
    Date of Patent: March 28, 2017
    Assignee: NOVARTIS AG
    Inventors: Fabrice Gallou, Joerg Matthias Sedelmeier, Caspar Vogel
  • PROCESS FOR THE MANUFACTURE OF CYCLIC UNDECAPEPTIDES
    Publication number: 20160304554
    Abstract: The present invention relates to processes and intermediates useful for the manufacture of cyclic undecapeptides, such as Alisporivir.
    Type: Application
    Filed: June 30, 2016
    Publication date: October 20, 2016
    Inventors: Fabrice GALLOU, Bernard RISS
  • PROCESS FOR THE MANUFACTURE OF CYCLIC UNDECAPEPTIDES
    Publication number: 20150087808
    Abstract: The present invention relates to processes and intermediates useful for the manufacture of cyclic undecapeptides, such as Alisporivir.
    Type: Application
    Filed: May 8, 2013
    Publication date: March 26, 2015
    Applicant: Novartis AG
    Inventors: Fabrice Gallou, Bernard Riss
  • Process for Preparing N-(4-Cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic Acid Ethyl Ester
    Publication number: 20150018577
    Abstract: This invention relates to novel processes for synthesizing N-(4-cyclohexyl-3-trifluoromethyl-benzyloxy)-acetimidic acid ethyl ester and to the compound of formula I below and other intermediates that are used in such processes.
    Type: Application
    Filed: February 1, 2013
    Publication date: January 15, 2015
    Inventors: Fabrice Gallou, Joerg Matthias Sedelmeier, Caspar Vogel
  • Process for preparing macrocyclic compounds
    Patent number: 8222369
    Abstract: Disclosed is a process for preparing a macrocyclic compound of the formula (I) wherein a hydroxyl-substituted macrocyclic compound of formula (3) is reacted with a sulfonyl-substituted compound of formula QUIN: The compounds of formula (I) are potent active agents for the treatment of hepatitis C virus (HCV) infection.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: July 17, 2012
    Assignee: Boehringer Ingelheim International GmbH
    Inventors: Carl Alan Busacca, Fabrice Gallou, Nizar Haddad, Azad Hossain, Suresh R. Kapadia, Jianxiu Liu, Chris H. Senanayake, Xudong Wei, Nathan K. Yee