Patents by Inventor Fabrice LAROSA

Fabrice LAROSA has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CAR-T CELLS TARGETING IL-1RAP AND THEIR USE
    Publication number: 20240139249
    Abstract: The present invention is relative to an isolated nucleic acid molecule encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an antibody or antibody fragment which includes a anti-IL-1RAP binding domain, polypeptides encoded by this nucleic acid molecule, isolated chimeric antigen receptor (CAR) molecule comprising such an antibody or antibody fragment, a vector comprising a nucleic acid molecule encoding a CAR, as well as a T cell comprising this vector. The present invention is also relative to the use of this T cell (autologous or allogeneic) expressing a CAR molecule to treat a proliferative disease in a mammal.
    Type: Application
    Filed: October 9, 2023
    Publication date: May 2, 2024
    Inventors: Christophe FERRAND, Marina DESCHAMPS, Fabrice LAROSA
  • CAR-T cells targeting IL-1RAP and their use
    Patent number: 11839630
    Abstract: The present invention is relative to an isolated nucleic acid molecule encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an antibody or antibody fragment which includes a anti-IL-1RAP binding domain, polypeptides encoded by this nucleic acid molecule, isolated chimeric antigen receptor (CAR) molecule comprising such an antibody or antibody fragment, a vector comprising a nucleic acid molecule encoding a CAR, as well as a T cell comprising this vector. The present invention is also relative to the use of this T cell (autologous or allogeneic) expressing a CAR molecule to treat a proliferative disease in a mammal.
    Type: Grant
    Filed: November 14, 2018
    Date of Patent: December 12, 2023
    Assignees: ETABLISSEMENT FRANCAIS DU SANG, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE, CENTRE HOSPITALIER UNIVERSITAIRE DE BESANCON, UNIVERSITE DE FRANCHE COMTE
    Inventors: Christophe Ferrand, Marina Deschamps, Fabrice Larosa
  • CAR-T CELLS TARGETING IL-1RAP AND THEIR USE IN ACUTE MYELOID LEUKEMIA (AML)
    Publication number: 20220235138
    Abstract: The present invention is relative to a cell comprising a nucleic acid molecule encoding a chimeric antigen receptor (CAR) for use in the treatment of acute myeloid leukemia (AML), wherein the CAR comprises an antibody or antibody fragment which includes an anti-IL-1RAP binding domain, a transmembrane domain, and an intracellular signaling domain comprising at least a stimulatory domain
    Type: Application
    Filed: May 27, 2020
    Publication date: July 28, 2022
    Inventors: Marina DESCHAMPS, Christophe FERRAND, Fabrice LAROSA, Walid WARDA
  • CAR-T CELLS TARGETING IL-1RAP AND THEIR USE
    Publication number: 20210008108
    Abstract: The present invention is relative to an isolated nucleic acid molecule encoding a chimeric antigen receptor (CAR), wherein the CAR comprises an antibody or antibody fragment which includes a anti-IL-1RAP binding domain, polypeptides encoded by this nucleic acid molecule, isolated chimeric antigen receptor (CAR) molecule comprising such an antibody or antibody fragment, a vector comprising a nucleic acid molecule encoding a CAR, as well as a T cell comprising this vector. The present invention is also relative to the use of this T cell (autologous or allogeneic) expressing a CAR molecule to treat a proliferative disease in a mammal.
    Type: Application
    Filed: November 14, 2018
    Publication date: January 14, 2021
    Inventors: Christophe FERRAND, Marina DESCHAMPS, Fabrice LAROSA