Patents by Inventor Fabrice Marquet
Fabrice Marquet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11707637Abstract: An ultrasound cardiac stimulation system includes: a system for measuring the heart electrical activity; a system for generating a beam of focussed ultrasound signals focussed on a targeted zone, the signals being calibrated to generate electrical stimulation in a zone of the heart, the beam generation being synchronised with a first selected time of the electrocardiogram, the generation of the beam corresponding to a pulse with a duration of less than 80 ms; a system for locating the targeted zone coupled with a system for positioning the system for generating the focussed beam to control the beam of focussed ultrasound signals in the targeted zone, the location system being synchronised with the system for generating the beam of focussed signals; a single monitoring system following in real time a temperature and tissue deformation in the targeted zone, the monitoring system taking measurements in synchronisation with the rhythm of the electrocardiogram.Type: GrantFiled: September 1, 2015Date of Patent: July 25, 2023Assignees: UNIVERSITE DE BORDEAUX, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUXInventors: Fabrice Marquet, Pierre Bour, Bruno Quesson, Fanny Vaillant, Remi Dubois
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Patent number: 11565136Abstract: A system for ablating or monitoring a zone of the heart, includes a system to measure the heart electrical activity; a phased array for generating a beam of focussed ultrasound signals on a targeted zone of the heart; an imaging system determining an image of a transcostal wall projected in an image plane of the phased array by taking into consideration a position and direction of the phased array and making it possible to deactivate elements of the phased array in accordance with the position of the elements with regard to the position of the projected image of the transcostal wall; a positioning system to control the position of a focussed zone of a beam of focussed ultrasound signals on the targeted zone, a monitoring system to measure a temperature and tissue deformation in the targeted zone; and a device for measuring a level of cavitation in the targeted zone.Type: GrantFiled: September 1, 2015Date of Patent: January 31, 2023Assignees: UNIVERSITE DE BORDEAUX, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUXInventors: Fabrice Marquet, Pierre Bour, Bruno Quesson, Fanny Vaillant
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Publication number: 20220193457Abstract: Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.Type: ApplicationFiled: March 9, 2022Publication date: June 23, 2022Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Elisa E. Konofagou, Fabrice Marquet, Yao-Sheng Tung
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Patent number: 11273329Abstract: Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.Type: GrantFiled: September 18, 2019Date of Patent: March 15, 2022Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Elisa E. Konofagou, Fabrice Marquet, Yao-Sheng Tung
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Publication number: 20200086146Abstract: Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.Type: ApplicationFiled: September 18, 2019Publication date: March 19, 2020Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Elisa E. Konofagou, Fabrice Marquet, Yao-Sheng Tung
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Patent number: 10441820Abstract: Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.Type: GrantFiled: November 26, 2013Date of Patent: October 15, 2019Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Elisa E. Konofagou, Fabrice Marquet, Yao-Sheng Tung
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Publication number: 20190192112Abstract: Systems and techniques for real-time, transcranial monitoring of safe blood-brain barrier opening include determining an approach angle for targeted blood-brain barrier opening proximate a predetermined region in a brain of a patient, and positioning an ultrasound transducer to generate a focused ultrasound signal at the determined approach angle to the predetermined region in the brain.Type: ApplicationFiled: July 23, 2018Publication date: June 27, 2019Applicant: The Trustees of Columbia University in the City of New YorkInventors: Elisa E. Konofagou, Tobias Teichert, Vincent P. Ferrera, Fabrice Marquet, Yao-Sheng Tung, Shih-Ying Wu
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Patent number: 10028723Abstract: Systems and techniques for real-time, transcranial monitoring of safe blood-brain barrier opening include determining an approach angle for targeted blood-brain barrier opening proximate a predetermined region in a brain of a patient, and positioning an ultrasound transducer to generate a focused ultrasound signal at the determined approach angle to the predetermined region in the brain.Type: GrantFiled: September 3, 2014Date of Patent: July 24, 2018Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORKInventors: Elisa E. Konofagou, Tobias Teichert, Vincent P. Ferrera, Fabrice Marquet, Yao-Sheng Teng, Shih-Ying Wu
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Publication number: 20170281984Abstract: An ultrasound cardiac stimulation system includes: a system for measuring the heart electrical activity; a system for generating a beam of focussed ultrasound signals focussed on a targeted zone, the signals being calibrated to generate electrical stimulation in a zone of the heart, the beam generation being synchronised with a first selected time of the electrocardiogram, the generation of the beam corresponding to a pulse with a duration of less than 80 ms; a system for locating the targeted zone coupled with a system for positioning the system for generating the focussed beam to control the beam of focussed ultrasound signals in the targeted zone, the location system being synchronised with the system for generating the beam of focussed signals; a single monitoring system following in real time a temperature and tissue deformation in the targeted zone, the monitoring system taking measurements in synchronisation with the rhythm of the electrocardiogram.Type: ApplicationFiled: September 1, 2015Publication date: October 5, 2017Applicants: CENTRE HOSPITALIER UNIVERSITAIRE DE BOURDEAUX, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITE DE BORDEAUXInventors: Fabrice MARQUET, Pierre BOUR, Bruno QUESSON, Fanny VAILLANT, Remi DUBOIS
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Publication number: 20170281983Abstract: A system for ablating or monitoring a zone of the heart, includes a system to measure the heart electrical activity; a phased array for generating a beam of focussed ultrasound signals on a targeted zone of the heart; an imaging system determining an image of a transcostal wall projected in an image plane of the phased array by taking into consideration a position and direction of the phased array and making it possible to deactivate elements of the phased array in accordance with the position of the elements with regard to the position of the projected image of the transcostal wall; a positioning system to control the position of a focussed zone of a beam of focussed ultrasound signals on the targeted zone, a monitoring system to measure a temperature and tissue deformation in the targeted zone; and a device for measuring a level of cavitation in the targeted zone.Type: ApplicationFiled: September 1, 2015Publication date: October 5, 2017Inventors: Fabrice MARQUET, Pierre BOUR, Bruno QUESSON, Fanny VAILLANT
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Publication number: 20150065871Abstract: Systems and techniques for real-time, transcranial monitoring of safe blood-brain barrier opening include determining an approach angle for targeted blood-brain barrier opening proximate a predetermined region in a brain of a patient, and positioning an ultrasound transducer to generate a focused ultrasound signal at the determined approach angle to the predetermined region in the brain.Type: ApplicationFiled: September 3, 2014Publication date: March 5, 2015Inventors: Elisa E. Konofagou, Tobias Teichert, Vincent P. Ferrera, Fabrice Marquet, Yao-Sheng Teng, Shih-Ying Wu
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Publication number: 20140114216Abstract: Systems and methods for cavitation-guided opening of a targeted region of tissue within a primate skull are provided. In one example, a method includes delivering one or more microbubbles to proximate the targeted region, applying an ultrasound beam, using a transducer, through the skull of the primate to the targeted region to open the tissue, transcranially acquiring acoustic emissions produced from an interaction between the one or more microbubbles and the tissue, and determining a cavitation spectrum from the acquired acoustic emissions.Type: ApplicationFiled: November 26, 2013Publication date: April 24, 2014Applicant: The Trustees of Columbia University in the City of New YorkInventors: Elisa E. KONOFAGOU, Fabrice Marquet, Yao-Sheng Tung