Publication number: 20220325299
Abstract: Disclosed are compositions for transfecting a nucleic acid molecule into a cell and their applications. Specifically, this relates to a composition suitable for transfecting a nucleic acid molecule into a cell, preferably a eukaryotic cell, including (i) at least one compound of general formula (II) or a tautomer, mesomer, racemate, enantiomer, diastereomer, or mixture thereof, or an acceptable salt thereof, and (ii) an acceptable excipient, buffering agent, cell culture medium, or transfection medium, wherein Y1, Y2, Y3, Z1, Z2, Z3, Z4, Z5, Z6, Z7, X1, X2, R3, P+, R, T, U and V are as defined in the description. Also disclosed are uses of the composition and to a method for in vitro or ex vivo transfection of live cells.
Type:
Application
Filed:
August 5, 2020
Publication date:
October 13, 2022
Inventors:
Malik HELLAL, Fabrice STOCK, Patrick ERBACHER, Yann PHILIPSON, Mégane DENU, Marine RICORDEL, Fanny PREMARTIN, Thibaut BENCHIMOL, Mathieu PORTE, Valérie TOUSSAINT MOREAU, Jonathan HAVARD
Publication number: 20220282281
Abstract: Disclosed are compositions for transfecting a nucleic acid molecule into a cell and their applications. Specifically, this relates to a composition suitable for transfecting a nucleic acid molecule into a cell, preferably a eukaryotic cell, including (i) at least one compound of general formula (I), preferably of general formula (III), or a tautomer, mesomer, racemate, enantiomer, diastereomer, or mixture thereof, or an acceptable salt thereof, and (ii) an acceptable excipient, buffering agent, cell culture medium, or transfection medium, wherein Y1, Y2, Y3, Z1, Z2, Z3, X1, X2, R3, P+, R and V are as defined in the description. Also disclosed are uses of the composition and to a method for in vitro or ex vivo transfection of live cells.
Type:
Application
Filed:
August 5, 2020
Publication date:
September 8, 2022
Inventors:
Malik HELLAL, Fabrice STOCK, Patrick ERBACHER, Yann PHILIPSON, Mégane DENU, Marine RICORDEL, Fanny PREMARTIN, Thibaut BENCHIMOL, Mathieu PORTE, Valérie TOUSSAINT MOREAU, Jonathan HAVARD