Patents by Inventor Fabricio MEDINA-BOLIVAR

Fabricio MEDINA-BOLIVAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11535856
    Abstract: The process and system led to the identification of prenyltransferase genes from elicitor-treated peanut hairy roots. One of the prenyltransferases, AhR4DT-1 catalyzes a key reaction involved in the biosynthesis of prenylated stilbenoids, in which resveratrol is prenylated at its C-4 position to form arachidin-2, while another, AhR3?DT-1, was able to add the prenyl group to C-3? of resveratrol. Each of these prenyltransferases has a high specificity for stilbenoid substrates, and their subcellular location in the plastid was confirmed by fluorescence microscopy. Structure analysis of the prenylated stilbenoids suggest that these two prenyltransferase activities represent the first committed steps in the biosynthesis of a large number of prenylated stilbenoids and their derivatives in peanut.
    Type: Grant
    Filed: July 6, 2020
    Date of Patent: December 27, 2022
    Assignees: ARKANSAS STATE UNIVERSITY—JONESBORO, INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
    Inventors: Luis Fabricio Medina-Bolivar, Tianhong Yang, Keithanne Mockaitis
  • Publication number: 20220054708
    Abstract: Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.
    Type: Application
    Filed: July 29, 2021
    Publication date: February 24, 2022
    Inventors: William L. Murphy, Gianluca Fontana, Joshua Gershlak, Glenn Gaudette, Pam Weathers, Tanja Dominko, Marsha Rolle, Sarah Hernandez, Carol Cramer, Fabricio Medina-Bolivar
  • Publication number: 20200332308
    Abstract: The process and system led to the identification of prenyltransferase genes from elicitor-treated peanut hairy roots. One of the prenyltransferases, AhR4DT-1 catalyzes a key reaction involved in the biosynthesis of prenylated stilbenoids, in which resveratrol is prenylated at its C-4 position to form arachidin-2, while another, AhR3?DT-1, was able to add the prenyl group to C-3? of resveratrol. Each of these prenyltransferases has a high specificity for stilbenoid substrates, and their subcellular location in the plastid was confirmed by fluorescence microscopy. Structure analysis of the prenylated stilbenoids suggest that these two prenyltransferase activities represent the first committed steps in the biosynthesis of a large number of prenylated stilbenoids and their derivatives in peanut.
    Type: Application
    Filed: July 6, 2020
    Publication date: October 22, 2020
    Inventors: Luis Fabricio Medina-Bolivar, Tianhong Yang, Keithanne Mockaitis
  • Patent number: 10704052
    Abstract: The process and system led to the identification of prenyltransferase genes from elicitor-treated peanut hairy roots. One of the prenyltransferases, AhR4DT-1 catalyzes a key reaction involved in the biosynthesis of prenylated stilbenoids, in which resveratrol is prenylated at its C-4 position to form arachidin-2, while another, AhR3?DT-1, was able to add the prenyl group to C-3? of resveratrol. Each of these prenyltransferases has a high specificity for stilbenoid substrates, and their subcellular location in the plastid was confirmed by fluorescence microscopy. Structure analysis of the prenylated stilbenoids suggest that these two prenyltransferase activities represent the first committed steps in the biosynthesis of a large number of prenylated stilbenoids and their derivatives in peanut.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: July 7, 2020
    Assignees: Arkansas State University—Jonesboro, Indiana University Research and Technology Corporation
    Inventors: Luis Fabricio Medina-Bolivar, Tianhong Yang, Keithanne Mockaitis
  • Publication number: 20190117839
    Abstract: Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.
    Type: Application
    Filed: March 14, 2017
    Publication date: April 25, 2019
    Applicants: Wisconsin Alumni Research Foundation, Arkansas State University - Jonesboro, Worcester Polytechnic Institute
    Inventors: William L. MURPHY, Gianluca FONTANA, Joshua GERSHLAK, Glenn GA UDETTE, Pam WEATHERS, Tanja DOMINKO, Marsha ROLLE, Sarah HERNANDEZ, Carol CRAMER, Fabricio MEDINA-BOLIVAR
  • Publication number: 20190040367
    Abstract: The process and system led to the identification of prenyltransferase genes from elicitor-treated peanut hairy roots. One of the prenyltransferases, AhR4DT-1 catalyzes a key reaction involved in the biosynthesis of prenylated stilbenoids, in which resveratrol is prenylated at its C-4 position to form arachidin-2, while another, AhR3?DT-1, was able to add the prenyl group to C-3? of resveratrol. Each of these prenyltransferases has a high specificity for stilbenoid substrates, and their subcellular location in the plastid was confirmed by fluorescence microscopy. Structure analysis of the prenylated stilbenoids suggest that these two prenyltransferase activities represent the first committed steps in the biosynthesis of a large number of prenylated stilbenoids and their derivatives in peanut.
    Type: Application
    Filed: June 16, 2017
    Publication date: February 7, 2019
    Inventors: Luis Fabricio Medina-Bolivar, Tianhong Yang, Keithanne Mockaitis
  • Patent number: 10144913
    Abstract: A method or process to increase the production of products of interest in plant material including plant cultures, such as, for example, cell suspension cultures, root cultures, and hairy root cultures is provided. In one embodiment, the method is to contacting the plant material with a precursor or xenobiotic when producing a product of interest from a plant. In another embodiment the plant material is also contacted with a trapping agent. The process may also provide for contacting an elicitor of the product of interest with the plant material. An embodiment provides for contacting an elicitor, precursor and trapping agent with the plant material. The ability to produce novel compounds such as glucosides and glucuronides is provided.
    Type: Grant
    Filed: March 13, 2017
    Date of Patent: December 4, 2018
    Assignee: Arkansas State University-Jonesboro
    Inventors: Luis Fabricio Medina-Bolivar, Tianhong Yang
  • Patent number: 9598707
    Abstract: A method to increase the production of products of interest in plant material including plant cultures, such as, for example, cell suspension cultures, root cultures, and hairy root cultures is provided. In one embodiment, the method is to contacting the plant material with a precursor or xenobiotic when producing a product of interest from a plant. In another embodiment the plant material is also contacted with a trapping agent. The process may also provide for contacting an elicitor of the product of interest with the plant material. An embodiment provides for contacting an elicitor, precursor and trapping agent with the plant material. The ability to produce novel compounds such as glucosides and glucuronides is provided.
    Type: Grant
    Filed: March 5, 2013
    Date of Patent: March 21, 2017
    Assignee: Arkansas State University-Jonesboro
    Inventors: Luis Fabricio Medina-Bolivar, Tianhong Yang
  • Publication number: 20160346226
    Abstract: The present invention relates generally to the treatment of virus infections. More specifically, the present invention relates to compositions and methods to treat rotavirus infections.
    Type: Application
    Filed: April 6, 2016
    Publication date: December 1, 2016
    Inventors: Luis Fabricio Medina-Bolivar, Rebecca D. Parr
  • Publication number: 20150328243
    Abstract: The present invention generally provides stilbenoid derivatives and methods for using stilbenoid derivatives to modulate the activity of cannabinoid receptors or scavenge reactive nitrogen species.
    Type: Application
    Filed: May 26, 2015
    Publication date: November 19, 2015
    Inventors: Anna Radominska-Pandya, Paul L. Prather, Luis Fabricio Medina-Bolivar, Philip R. Mayeux
  • Patent number: 9095598
    Abstract: The present invention generally provides stilbenoid derivatives and methods for using stilbenoid derivatives to modulate the activity of cannabinoid receptors or scavenge reactive nitrogen species.
    Type: Grant
    Filed: December 28, 2011
    Date of Patent: August 4, 2015
    Assignees: The Board of Trustees of the University of Arkansas, Arkansas State University—Jonesboro
    Inventors: Anna Radominska-Pandya, Paul L. Prather, Luis Fabricio Medina-Bolivar, Philip R. Mayeux
  • Publication number: 20140147886
    Abstract: A method to increase the production of products of interest in plant material including plant cultures, such as, for example, cell suspension cultures, root cultures, and hairy root cultures is provided. In one embodiment, the method is to contacting the plant material with a precursor or xenobiotic when producing a product of interest from a plant. In another embodiment the plant material is also contacted with a trapping agent. The process may also provide for contacting an elicitor of the product of interest with the plant material. An embodiment provides for contacting an elicitor, precursor and trapping agent with the plant material. The ability to produce novel compounds such as glucosides and glucuronides is provided.
    Type: Application
    Filed: March 5, 2013
    Publication date: May 29, 2014
    Applicant: ARKANSAS STATE UNIVERSITY
    Inventors: Luis Fabricio Medina-Bolivar, Tianhong Yang
  • Publication number: 20120165281
    Abstract: The present invention generally provides stilbenoid derivatives and methods for using stilbenoid derivatives to modulate the activity of cannabinoid receptors or scavenge reactive nitrogen species.
    Type: Application
    Filed: December 28, 2011
    Publication date: June 28, 2012
    Applicants: ARKANSAS STATE UNIVERSITY - JONESBORO, The Board of Trustees of the University of Arkansa
    Inventors: Anna Radominska-Pandya, Paul L. Prather, Luis Fabricio Medina-Bolivar, Philip R. Mayeux
  • Publication number: 20100130623
    Abstract: Improved methods for production of stilbenoids including resveratrol, pinosylvin and their respective derivatives are provided, including producing root cultures from plant cells and eliciting production of the stilbenes. The plant cells in an embodiment are contacted with substances which elicit production of the stilbenoid compounds.
    Type: Application
    Filed: December 15, 2009
    Publication date: May 27, 2010
    Applicant: Arkansas State University Research and Development Institute
    Inventors: Luis Fabricio Medina-Bolivar, Maureen Dolan
  • Patent number: 7666677
    Abstract: Improved methods for production of stilbenoids including resveratrol, pinosylvin and their respective derivatives are provided, including producing hairy roots from plant cells and eliciting production of the stilbenes. The plant cells in an embodiment are infected by Agrobacterium to produce hairy roots, and contacted with substances which elicit production of the stilbenoid compounds.
    Type: Grant
    Filed: July 3, 2007
    Date of Patent: February 23, 2010
    Inventors: Luis Fabricio Medina-Bolivar, Maureen Dolan, Selester Bennett, Jose M. Condori, John F. Hubstenberger