Patents by Inventor Fabricio MEDINA-BOLIVAR
Fabricio MEDINA-BOLIVAR has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11535856Abstract: The process and system led to the identification of prenyltransferase genes from elicitor-treated peanut hairy roots. One of the prenyltransferases, AhR4DT-1 catalyzes a key reaction involved in the biosynthesis of prenylated stilbenoids, in which resveratrol is prenylated at its C-4 position to form arachidin-2, while another, AhR3?DT-1, was able to add the prenyl group to C-3? of resveratrol. Each of these prenyltransferases has a high specificity for stilbenoid substrates, and their subcellular location in the plastid was confirmed by fluorescence microscopy. Structure analysis of the prenylated stilbenoids suggest that these two prenyltransferase activities represent the first committed steps in the biosynthesis of a large number of prenylated stilbenoids and their derivatives in peanut.Type: GrantFiled: July 6, 2020Date of Patent: December 27, 2022Assignees: ARKANSAS STATE UNIVERSITY—JONESBORO, INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATIONInventors: Luis Fabricio Medina-Bolivar, Tianhong Yang, Keithanne Mockaitis
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Publication number: 20220054708Abstract: Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.Type: ApplicationFiled: July 29, 2021Publication date: February 24, 2022Inventors: William L. Murphy, Gianluca Fontana, Joshua Gershlak, Glenn Gaudette, Pam Weathers, Tanja Dominko, Marsha Rolle, Sarah Hernandez, Carol Cramer, Fabricio Medina-Bolivar
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Publication number: 20200332308Abstract: The process and system led to the identification of prenyltransferase genes from elicitor-treated peanut hairy roots. One of the prenyltransferases, AhR4DT-1 catalyzes a key reaction involved in the biosynthesis of prenylated stilbenoids, in which resveratrol is prenylated at its C-4 position to form arachidin-2, while another, AhR3?DT-1, was able to add the prenyl group to C-3? of resveratrol. Each of these prenyltransferases has a high specificity for stilbenoid substrates, and their subcellular location in the plastid was confirmed by fluorescence microscopy. Structure analysis of the prenylated stilbenoids suggest that these two prenyltransferase activities represent the first committed steps in the biosynthesis of a large number of prenylated stilbenoids and their derivatives in peanut.Type: ApplicationFiled: July 6, 2020Publication date: October 22, 2020Inventors: Luis Fabricio Medina-Bolivar, Tianhong Yang, Keithanne Mockaitis
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Patent number: 10704052Abstract: The process and system led to the identification of prenyltransferase genes from elicitor-treated peanut hairy roots. One of the prenyltransferases, AhR4DT-1 catalyzes a key reaction involved in the biosynthesis of prenylated stilbenoids, in which resveratrol is prenylated at its C-4 position to form arachidin-2, while another, AhR3?DT-1, was able to add the prenyl group to C-3? of resveratrol. Each of these prenyltransferases has a high specificity for stilbenoid substrates, and their subcellular location in the plastid was confirmed by fluorescence microscopy. Structure analysis of the prenylated stilbenoids suggest that these two prenyltransferase activities represent the first committed steps in the biosynthesis of a large number of prenylated stilbenoids and their derivatives in peanut.Type: GrantFiled: June 16, 2017Date of Patent: July 7, 2020Assignees: Arkansas State University—Jonesboro, Indiana University Research and Technology CorporationInventors: Luis Fabricio Medina-Bolivar, Tianhong Yang, Keithanne Mockaitis
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Publication number: 20190117839Abstract: Decellularized plant tissues and the use of these plant tissues as scaffolds are disclosed herein. Particularly, decellularized plant tissues are functionalized such to allow for human cell adhesion, thereby allowing for their use as scaffolds for human cells. These scaffolds can then be used in a number of applications/markets, including as research tools for tissue engineering, regenerative medicine, and basic cellular biology.Type: ApplicationFiled: March 14, 2017Publication date: April 25, 2019Applicants: Wisconsin Alumni Research Foundation, Arkansas State University - Jonesboro, Worcester Polytechnic InstituteInventors: William L. MURPHY, Gianluca FONTANA, Joshua GERSHLAK, Glenn GA UDETTE, Pam WEATHERS, Tanja DOMINKO, Marsha ROLLE, Sarah HERNANDEZ, Carol CRAMER, Fabricio MEDINA-BOLIVAR
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Publication number: 20190040367Abstract: The process and system led to the identification of prenyltransferase genes from elicitor-treated peanut hairy roots. One of the prenyltransferases, AhR4DT-1 catalyzes a key reaction involved in the biosynthesis of prenylated stilbenoids, in which resveratrol is prenylated at its C-4 position to form arachidin-2, while another, AhR3?DT-1, was able to add the prenyl group to C-3? of resveratrol. Each of these prenyltransferases has a high specificity for stilbenoid substrates, and their subcellular location in the plastid was confirmed by fluorescence microscopy. Structure analysis of the prenylated stilbenoids suggest that these two prenyltransferase activities represent the first committed steps in the biosynthesis of a large number of prenylated stilbenoids and their derivatives in peanut.Type: ApplicationFiled: June 16, 2017Publication date: February 7, 2019Inventors: Luis Fabricio Medina-Bolivar, Tianhong Yang, Keithanne Mockaitis
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Patent number: 10144913Abstract: A method or process to increase the production of products of interest in plant material including plant cultures, such as, for example, cell suspension cultures, root cultures, and hairy root cultures is provided. In one embodiment, the method is to contacting the plant material with a precursor or xenobiotic when producing a product of interest from a plant. In another embodiment the plant material is also contacted with a trapping agent. The process may also provide for contacting an elicitor of the product of interest with the plant material. An embodiment provides for contacting an elicitor, precursor and trapping agent with the plant material. The ability to produce novel compounds such as glucosides and glucuronides is provided.Type: GrantFiled: March 13, 2017Date of Patent: December 4, 2018Assignee: Arkansas State University-JonesboroInventors: Luis Fabricio Medina-Bolivar, Tianhong Yang
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Patent number: 9598707Abstract: A method to increase the production of products of interest in plant material including plant cultures, such as, for example, cell suspension cultures, root cultures, and hairy root cultures is provided. In one embodiment, the method is to contacting the plant material with a precursor or xenobiotic when producing a product of interest from a plant. In another embodiment the plant material is also contacted with a trapping agent. The process may also provide for contacting an elicitor of the product of interest with the plant material. An embodiment provides for contacting an elicitor, precursor and trapping agent with the plant material. The ability to produce novel compounds such as glucosides and glucuronides is provided.Type: GrantFiled: March 5, 2013Date of Patent: March 21, 2017Assignee: Arkansas State University-JonesboroInventors: Luis Fabricio Medina-Bolivar, Tianhong Yang
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Publication number: 20160346226Abstract: The present invention relates generally to the treatment of virus infections. More specifically, the present invention relates to compositions and methods to treat rotavirus infections.Type: ApplicationFiled: April 6, 2016Publication date: December 1, 2016Inventors: Luis Fabricio Medina-Bolivar, Rebecca D. Parr
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Publication number: 20150328243Abstract: The present invention generally provides stilbenoid derivatives and methods for using stilbenoid derivatives to modulate the activity of cannabinoid receptors or scavenge reactive nitrogen species.Type: ApplicationFiled: May 26, 2015Publication date: November 19, 2015Inventors: Anna Radominska-Pandya, Paul L. Prather, Luis Fabricio Medina-Bolivar, Philip R. Mayeux
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Patent number: 9095598Abstract: The present invention generally provides stilbenoid derivatives and methods for using stilbenoid derivatives to modulate the activity of cannabinoid receptors or scavenge reactive nitrogen species.Type: GrantFiled: December 28, 2011Date of Patent: August 4, 2015Assignees: The Board of Trustees of the University of Arkansas, Arkansas State University—JonesboroInventors: Anna Radominska-Pandya, Paul L. Prather, Luis Fabricio Medina-Bolivar, Philip R. Mayeux
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Publication number: 20140147886Abstract: A method to increase the production of products of interest in plant material including plant cultures, such as, for example, cell suspension cultures, root cultures, and hairy root cultures is provided. In one embodiment, the method is to contacting the plant material with a precursor or xenobiotic when producing a product of interest from a plant. In another embodiment the plant material is also contacted with a trapping agent. The process may also provide for contacting an elicitor of the product of interest with the plant material. An embodiment provides for contacting an elicitor, precursor and trapping agent with the plant material. The ability to produce novel compounds such as glucosides and glucuronides is provided.Type: ApplicationFiled: March 5, 2013Publication date: May 29, 2014Applicant: ARKANSAS STATE UNIVERSITYInventors: Luis Fabricio Medina-Bolivar, Tianhong Yang
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Publication number: 20120165281Abstract: The present invention generally provides stilbenoid derivatives and methods for using stilbenoid derivatives to modulate the activity of cannabinoid receptors or scavenge reactive nitrogen species.Type: ApplicationFiled: December 28, 2011Publication date: June 28, 2012Applicants: ARKANSAS STATE UNIVERSITY - JONESBORO, The Board of Trustees of the University of ArkansaInventors: Anna Radominska-Pandya, Paul L. Prather, Luis Fabricio Medina-Bolivar, Philip R. Mayeux
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Publication number: 20100130623Abstract: Improved methods for production of stilbenoids including resveratrol, pinosylvin and their respective derivatives are provided, including producing root cultures from plant cells and eliciting production of the stilbenes. The plant cells in an embodiment are contacted with substances which elicit production of the stilbenoid compounds.Type: ApplicationFiled: December 15, 2009Publication date: May 27, 2010Applicant: Arkansas State University Research and Development InstituteInventors: Luis Fabricio Medina-Bolivar, Maureen Dolan
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Patent number: 7666677Abstract: Improved methods for production of stilbenoids including resveratrol, pinosylvin and their respective derivatives are provided, including producing hairy roots from plant cells and eliciting production of the stilbenes. The plant cells in an embodiment are infected by Agrobacterium to produce hairy roots, and contacted with substances which elicit production of the stilbenoid compounds.Type: GrantFiled: July 3, 2007Date of Patent: February 23, 2010Inventors: Luis Fabricio Medina-Bolivar, Maureen Dolan, Selester Bennett, Jose M. Condori, John F. Hubstenberger