Abstract: The present invention relates in general to the field of Bifidobacteria. In particular the present invention relates to the field of Bifidobacteria with a modulated stress resistance. One embodiment of the present invention is a Bifidobacterium with a constitutively modulated DnaK, DnaJ, GrpE and/or CIpB expression.

Abstract: The present invention relates to supporting weight management, weight loss and/or to the prevention and/or treatment of metabolic disorders. In particular the present invention relates to preventing and/or treating metabolic disorders by modulating, in particular reducing the amount of proteobacteria and/or deferribacteres in the gut. One embodiment of the present invention relates to the use of a primary composition comprising an agent that reduces the amount of proteobacteria, preferably gamma-proteobacteria, even more preferred enterobacteria; and/or deferribacteres in the gut for the preparation of a composition to treat or prevent metabolic disorders, to support weight loss and/or to support weight management.

Abstract: A Bifidobacterium comprising a genome that is customized so as to lack an operable functional gene is disclosed. A method of making such cells is also disclosed. The method is used to make Bifidobacterium cells that lack certain functional antibiotic resistance genes, such as tetW, and are sensitive to antibiotics such as tetracycline.

Abstract: The present invention pertains to the use of the DNA sequence of a Lactobacillus johnsonii strain, in particular to its genomic sequence for elucidating interactions of micro-organism with hosts they colonize, and moreover for elucidating the basis of probiotic properties exhibited by such strain. In addition, the present invention also relates to methods of detecting nucleic acids or polypeptides of Lactobacilli and related species, respectively. A data carrier is provided comprising nucleotide sequences and/or polypeptide sequences of La1.

Abstract: A novel gene of Bifidobacteria and the polypeptides encoded thereby. In particular, a gene belonging to the Serpin superfamily and its use in the production of bacterial Serpins is provided. Also provided are vectors, host cells, and methods for producing bacterial Serpin polynucleotides and/or polypeptides.

Abstract: The present invention pertains to the use of the DNA sequence of a Lactobacillus johnsonii strain, in particular to its genomic sequence for elucidating interactions of micro-organism with hosts they colonize, and moreover for elucidating the basis of probiotic properties exhibited by such strain. In addition, the present invention also relates to methods of detecting nucleic acids or polypeptides of Lactobacilli and related species, respectively. A data carrier is provided comprising nucleotide sequences and/or polypeptide sequences of La1.

Abstract: The present invention pertains to the use of the DNA sequence of a Lactobacillus johnsonii strain, in particular to its genomic sequence for elucidating interactions of micro-organism with hosts they colonize, and moreover for elucidating the basis of probiotic properties exhibited by such strain. In addition, the present invention also relates to methods of detecting nucleic acids or polypeptides of Lactobacilli and related species, respectively. A data carrier is provided comprising nucleotide sequences and/or polypeptide sequences of La1.

Abstract: A novel microorganism of the genus Bifidobacterium longum, in particular to its genomic and plasmid sequence and to a method of producing polypeptides of said Bifidobacterium, respectively. Also methods of detecting these nucleic acids or polypeptides, respectively. A data carrier is provided comprising nucleotide sequences and/or polypeptide sequences of NCC2705. In addition, the Bifidobacterium longum strain NCC2705 and also to food and pharmaceutical compositions containing said Bifidobacterium or active components thereof for the prevention and/or treatment of diarrhoea brought about by rotaviruses and pathogenic bacteria are provided.

Abstract: The invention relates to phosphopeptides inhibiting protein tyrosine phosphatases, and their uses.

Abstract: The present invention pertains to a novel micro-organism of the genus Bifidobacterium longum, in particular to its genomic and plasmid sequence and to a method of producing polypeptides of said Bifidobacterium, respectively. The invention also relates to methods of detecting these nucleic acids or polypeptides, respectively. A data carrier is provided comprising nucleotide sequences and/or polypeptide sequences of NCC2705. In addition, the present invention pertains to the Bifidobacterium longum strain NCC2705 and also to food and pharmaceutical compositions containing said Bifidobacterium or active components thereof for the prevention and/or treatment of diarrhoea brought about by rotaviruses and pathogenic bacteria.

Abstract: The present invention pertains to a novel gene of Bifidobacteria and to the polypeptides encoded thereby. In particular, the present invention pertains to a gene belonging to the Serpin superfamily and its use in the production of bacterial Serpins. Also provides are vectors host cells, and methods for producing bacterial Serpin polynucleotides and/or polypeptides.