Patents by Inventor Fabrizio D'Adda Di Fagagna

Fabrizio D'Adda Di Fagagna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • THERAPEUTIC OLIGONUCLEOTIDES
    Publication number: 20210087567
    Abstract: The present invention relates to an oligonucleotide comprising one of the following sequence: (TTAGGG) SEQ ID No. 1, (TAGGGT) SEQ ID No. 2, (AGGGTT) SEQ ID No. 3, (GGGTTA) SEQ ID No. 4, (GGTTAG) SEQ ID No. 5 or (GTTAGG) SEQ ID No. 6 or a complementary sequence thereof or a fragment or a variant or a mixture thereof for use in the treatment and/or prevention of a disease characterized by alternative lengthening of telomeres or a non-cancer condition associated with telomere dysfunction and relative pharmaceutical compositions and to relative pharmaceutical composition and method.
    Type: Application
    Filed: October 7, 2020
    Publication date: March 25, 2021
    Inventors: Fabrizio d'Adda di Fagagna, Francesca Rossiello, Julio Aguado, Corey Jones-Weinert
  • RNA PRODUCTS AND USES THEREOF
    Publication number: 20190211331
    Abstract: Small RNAs, inhibitors thereof, inhibitors of enzymes producing small RNAs, and the use of these to modulate the response of a cell to a DNA damaging event. A method of detecting the presence of, or of quantifying DNA damage.
    Type: Application
    Filed: February 7, 2019
    Publication date: July 11, 2019
    Inventors: Fabrizio d'Adda di Fagagna, Sofia Francia, Flavia Michelini, Francesca Rossiello
  • RNA products and uses thereof
    Patent number: 10240154
    Abstract: The present invention relates to small RNAs, inhibitors thereof, inhibitors of enzymes producing thereof, and their use to modulate the response of a cell to a DNA damaging event. The invention concerns also a method to detect the presence or quantify DNA damage.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: March 26, 2019
    Assignee: IFOM Fondazione Istituto FIRC di Oncologia Molecolare
    Inventors: Fabrizio d'Adda di Fagagna, Sofia Francia, Flavia Michelini, Francesca Rossiello
  • THERAPEUTIC OLIGONUCLEOTIDES
    Publication number: 20180223279
    Abstract: The present invention relates to an oligonucleotide comprising one of the following sequence: (TTAGGG) SEQ ID No. 1, (TAGGGT) SEQ ID No. 2, (AGGGTT) SEQ ID No. 3, (GGGTTA) SEQ ID No. 4, (GGTTAG) SEQ ID No. 5 or (GTTAGG) SEQ ID No. 6 or a complementary sequence thereof or a fragment or a variant or a mixture thereof for use in the treatment and/or prevention of a disease characterized by alternative lengthening of telomeres or a non-cancer condition associated with telomere dysfunction and relative pharmaceutical compositions and to relative pharmaceutical composition and method.
    Type: Application
    Filed: July 29, 2016
    Publication date: August 9, 2018
    Inventors: Fabrizio d'Adda di Fagagna, Francesca Rossiello, Julio Aguado, Corey Jones-Weinert
  • RNA PRODUCTS AND USES THEREOF
    Publication number: 20180066251
    Abstract: The present invention relates to small RNAs, inhibitors thereof, inhibitors of enzymes producing thereof, and their use to modulate the response of a cell to a DNA damaging event. The invention concerns also a method to detect the presence or quantify DNA damage.
    Type: Application
    Filed: March 31, 2017
    Publication date: March 8, 2018
    Inventors: Fabrizio d'Adda di Fagagna, Sofia Francia, Flavia Michelini, Francesca Rossiello
  • RNA products and uses thereof
    Patent number: 9708606
    Abstract: The present invention relates to small RNAs, inhibitors thereof, inhibitors of enzymes producing thereof, and their use to modulate the response of a cell to a DNA damaging event. The invention concerns also a method to detect the presence or quantify DNA damage.
    Type: Grant
    Filed: May 10, 2013
    Date of Patent: July 18, 2017
    Assignee: IFOM Fondazione Istituto FIRC di Oncologie Molecolare
    Inventors: Fabrizio d'Adda di Fagagna, Sofia Francia, Flavia Michelini, Francesca Rossiello
  • RNA PRODUCTS AND USES THEREOF
    Publication number: 20150119448
    Abstract: The present invention relates to small RNAs, inhibitors thereof, inhibitors of enzymes producing thereof, and their use to modulate the response of a cell to a DNA damaging event. The invention concerns also a method to detect the presence or quantify DNA damage.
    Type: Application
    Filed: May 10, 2013
    Publication date: April 30, 2015
    Inventors: Fabrizio D'Adda Di Fagagna, Sofia Francia, Flavia Michelini, Francesca Rossiello
  • Methods and means for the treatment of disorders associated with cellular senescence
    Publication number: 20070099186
    Abstract: This invention relates to mechanisms of cellular senescence and, in particular, to the role of DNA repair and DNA damage checkpoint pathways in the induction and maintenance of the senescent state. Methods and means of inducing cell cycle progression in senescent cells by inhibiting DNA damage checkpoint pathways are provided herein. These methods and means provide agents and therapies for the treatment of senescent associated disorders.
    Type: Application
    Filed: April 21, 2004
    Publication date: May 3, 2007
    Inventors: Fabrizio D'Adda Di Fagagna, Philip Reaper, Stephen Jackson