Patents by Inventor Fabrizio Giorgi

Fabrizio Giorgi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8598384
    Abstract: The present invention relates to a new crystalline form of R-4-trimethylammonium-3-(tetradecylcarbamoyl)-amino butyrate (also named crystalline Form I of ST 1326 or teglicar), a process for its preparation and pharmaceutical compositions containing same.
    Type: Grant
    Filed: July 31, 2008
    Date of Patent: December 3, 2013
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Walter Cabri, Mauro Marzi, Fabrizio Giorgi, Emanuela Tassoni
  • Patent number: 8269007
    Abstract: This invention relates to a process for preparing a crystalline form of (4S)-11(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3?4?:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing from methanol.
    Type: Grant
    Filed: July 22, 2008
    Date of Patent: September 18, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite SpA
    Inventors: Walter Cabri, Mauro Marzi, Fabrizio Giorgi, Elena Badaloni, Silvia Armaroli, Giuseppe Marazzi
  • Patent number: 8124769
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: February 28, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Patent number: 8101758
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Grant
    Filed: August 17, 2010
    Date of Patent: January 24, 2012
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Publication number: 20110136905
    Abstract: The present invention relates to a new crystalline form of R-4-trimethylammonium-3-(tetradecylcarbamoyl)-amino butyrate (also named crystalline Form I of ST 1326 or teglicar), a process for its preparation and pharmaceutical compositions containing same.
    Type: Application
    Filed: July 31, 2008
    Publication date: June 9, 2011
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Walter Cabri, Mauro Marzi, Fabrizio Giorgi, Emanuela Tassoni
  • Publication number: 20100311784
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Application
    Filed: August 17, 2010
    Publication date: December 9, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITIE SPA
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Publication number: 20100311783
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Application
    Filed: August 17, 2010
    Publication date: December 9, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITIE SPA
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Publication number: 20100249414
    Abstract: This invention relates to a process for preparing a crystalline form of (4S)-11-(dimethoxymethyl)-4-ethyl-4-hydroxy-1H-pyrano[3?,4?:6,7]indolizino[1,2-b]qui-noline-3,14(4H,12H)-dione (also named 7-(dimethoxy-methyl)camptothecin). With the provision of a particular crystallization step, in appropriate way, a new crystalline form of the above compound is obtained. The process for the preparation of the polymorph Form II comprises transforming camptothecin to the corresponding 7-(dimethoxy-methyl)-camptothecin, and crystallizing it from methanol.
    Type: Application
    Filed: July 22, 2008
    Publication date: September 30, 2010
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Walter Cabri, Mauro Marzi, Fabrizio Giorgi, Elena Badaloni, Silvia Armaroli, Giuseppe Marazzi
  • Patent number: 7799921
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Grant
    Filed: December 16, 2005
    Date of Patent: September 21, 2010
    Assignee: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Publication number: 20090239893
    Abstract: A stereoselective process for preparing 7-[(E)-t-butyloxyiminomethyl]-camptothecin (also known as gimatecan) is herein disclosed. With the addition of further dissolution and precipitation steps carried out in appropriate different solvent mixtures, four new crystalline forms of gimatecan are also obtainable by using the same stereoselective process.
    Type: Application
    Filed: December 16, 2005
    Publication date: September 24, 2009
    Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.
    Inventors: Paolo Carminati, Maria Ornella Tinti, Mauro Marzi, Fabrizio Giorgi, Walter Cabri, Marco Alpegiani, Domenico Vergani, Paolo Ghetti
  • Publication number: 20080293812
    Abstract: Pamoic acid or its derivatives of formula (I) are used to treat diseases characterized by deposits of amyloid aggregates.
    Type: Application
    Filed: November 1, 2007
    Publication date: November 27, 2008
    Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S. P.A.,
    Inventors: Maria Grazia Gallo, Maria Grazia Cima, Fabrizio Giorgi, Maria Ornella Tinti, Paola Piovesan, Orlando Ghirardi
  • Publication number: 20060205967
    Abstract: The use of pamoic acid or of one of its derivatives is described with general formula (I), in which groups R1 and R5 are as indicated in the description, or of one of their pharmaceutically acceptable salts, for the preparation of a medicament for the treatment of diseases characterized by deposits of amyloid aggregates.
    Type: Application
    Filed: May 11, 2006
    Publication date: September 14, 2006
    Applicant: Sigma-Tau Industrie Farmaceutiche Riunite S.p.A.
    Inventors: Maria Grazia Gallo, Maria Grazia Cima, Fabrizio Giorgi, Maria Ornella Tinti, Paola Piovesan, Orlando Ghirardi
  • Publication number: 20040029963
    Abstract: The use of pamoic acid or of one of its derivatives is described with general formula (I), in which groups R1 and R5 are as indicated in the description, or of one of their pharmaceutically acceptable salts, for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates.
    Type: Application
    Filed: January 31, 2003
    Publication date: February 12, 2004
    Inventors: Maria Grazia Gallo, Maria Grazia Cima, Fabrizio Giorgi, Maria Ornella Tinti, Paola Piovesan, Orlando Ghirardi