Patents by Inventor Fabrizio Marcucci

Fabrizio Marcucci has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of polymer bio-active conjugates
    Patent number: 6172202
    Abstract: A process for the preparation of a conjugate between a poly (ethylene glycol) and a protein or glycoprotein, the process comprising specifically binding the domain to a specific binder, to shield the domain from the poly (ethylene glycol) in the following conjugating step, thereafter conjugating the poly (ethylene glycol) to the protein or glycoprotein, wherein conjugation of the poly (ethylene glycol) to the domain is avoided and thereafter releasing the specific binder from the domain without releasing the poly (ethylene glycol) from the protein or glycoprotein, wherein the protein or glycoprotein is other than a proteolytic enzyme selected from the group consisting of trypsin, urokinase, tissue plasminogen activator, plasmin, chymotrypsin, elastase and kallikrein.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: January 9, 2001
    Assignee: Pharmacia S.p.A.
    Inventors: Fabrizio Marcucci, Ruth Gregory
  • Oligopeptides derived from C-reactive protein fragments
    Patent number: 6057295
    Abstract: Oligopeptides derived from fragments of C-reactive proteins and their use as immunomodulating agents in the therapy of cardiovascular and inflammatory diseases.
    Type: Grant
    Filed: June 11, 1996
    Date of Patent: May 2, 2000
    Assignee: Italfarmaco S.p.A.
    Inventors: Patrizia Caretto, Flavio Leoni, Fabrizio Marcucci, Gianni Gromo, Paolo Mascagni, Massimo Pinori, Silvana Cappelletti
  • Diesters of carbonic acid endowed with antiviral and anti-inflammatory activity
    Patent number: 5827881
    Abstract: Diesters of carbonic acid disubstituted with primary, secondary or tertiary amine groups, pharmaceutically acceptable salts thereof, and their use as antiviral and inti-inflammatory agents.
    Type: Grant
    Filed: June 4, 1997
    Date of Patent: October 27, 1998
    Assignee: Italfarmaco S.P.A.
    Inventors: Alberto Sala, Giorgio Bertolini, Gianfranco Pavich, Fabrizio Marcucci, Gianni Gromo, Giuliana Porro
  • Monoclonal antibodies against human Tumor Necrosis Factor .alpha.
    Patent number: 5436154
    Abstract: A monoclonal antibody is provided which is able to neutralize both human TNF .alpha. and TNF .beta., or a binding fragment thereof. A stable hybridoma cell line and progeny thereof are also provided which secrete such a monoclonal antibody. The monoclonal antibody or a fragment thereof may be used to detect the content of human TNF in a sample of body fluid.
    Type: Grant
    Filed: December 13, 1991
    Date of Patent: July 25, 1995
    Assignee: Farmitalia Carlo Erba S.R.L.
    Inventors: Elena Barbanti, Marta Ghislieri, Fabrizio Marcucci, Domenico Trizio