Patents by Inventor Fadel Alexis SAMATEY

Fadel Alexis SAMATEY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Flagellar and needle complex (injectosome) loop as anti bacterial drug target
    Patent number: 9809595
    Abstract: The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof. Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: November 7, 2017
    Assignee: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION
    Inventors: Fadel Alexis Samatey, Vladimir A Meshcheryakov, Hideyuki Matsunami, Akio Kitao
  • FLAGELLAR AND NEEDLE COMPLEX (INJECTOSOME) LOOP AS ANTI BACTERIAL DRUG TARGET
    Publication number: 20170049779
    Abstract: The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.
    Type: Application
    Filed: August 15, 2016
    Publication date: February 23, 2017
    Applicant: OKINAWA INSTITUTE OF SCIENCE AND TECHNOLOGY SCHOOL CORPORATION
    Inventors: Fadel Alexis SAMATEY, Vladimir A. MESHCHERYAKOV, Hideyuki MATSUNAMI, Akio KITAO
  • FLAGELLAR AND NEEDLE COMPLEX (INJECTOSOME) LOOP AS ANTI BACTERIAL DRUG TARGET
    Publication number: 20160002239
    Abstract: The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof. Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.
    Type: Application
    Filed: February 27, 2014
    Publication date: January 7, 2016
    Inventors: Fadel Alexis SAMATEY, Vladimir A MESHCHERYAKOV, Hideyuki MATSUNAMI, Akio KITAO