Patents by Inventor Fadia El-Fehail Ali

Fadia El-Fehail Ali has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fibrinogen receptor antagonists
    Patent number: 6069143
    Abstract: This invention relates to compounds of the formula: ##STR1## which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
    Type: Grant
    Filed: January 11, 1996
    Date of Patent: May 30, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Fadia El-Fehail Ali, William Edward Bondinell, Raul Rolando Calvo, Thomas Wen-Fu Ku, William Henry Miller, James Samanen, Joseph Walter Venslavsky, Tobias Oregon Yellin
  • Fibrinogen receptor antagonists
    Patent number: 6037343
    Abstract: This invention relates to compound of formula (I) which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
    Type: Grant
    Filed: December 22, 1995
    Date of Patent: March 14, 2000
    Assignee: Smithkline Beecham Corporation
    Inventor: Fadia El-Fehail Ali
  • Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
    Patent number: 5977101
    Abstract: Vitronectin receptor antagonists having the formula: ##STR1## which are useful for the treatment of inflammation, cancer and cardiovascular disorders, such as atherosclerosis and restenosis, and diseases wherein bone resorption is a factor, such as osteoporsis.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: November 2, 1999
    Assignee: SmithKline Beecham Corporation
    Inventors: Fadia El-Fehail Ali, William Bondinell, William Francis Huffman, M. Amparo Lago, Richard McCulloch Keenan, Chet Kwon, William Henry Miller, Thomas Nguyen, Dennis T. Takata
  • Fibrinogen receptor antagonists
    Patent number: 5900422
    Abstract: This invention relates to compounds of the formula: ##STR1## which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, and a method for inhibiting platelet aggregation.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: May 4, 1999
    Assignee: SmithKline Beecham Corporation
    Inventor: Fadia El-Fehail Ali
  • Anti-aggregatory peptides
    Patent number: 5849690
    Abstract: This invention relates to compounds which are effective for inhibiting platelet aggregation, pharmaceutical compositions for effecting such activity, a method for inhibiting platelet aggregation and clot formation in a mammal, and a method for inhibiting reocclusion of a blood vessel following fibrinolytic therapy.
    Type: Grant
    Filed: July 22, 1992
    Date of Patent: December 15, 1998
    Assignee: SmithKline Beecham Corporation
    Inventors: Fadia El-Fehail Ali, James Samanen
  • Cyclic anti-aggregatory peptides
    Patent number: 5643872
    Abstract: This invention relates to compounds of the formula: ##STR1## wherein: A' is absent, Asn, Gln, Ala or Abu;A is absent or a D- or L-amino acid chosen from Arg, HArg, (Me.sub.2)Arg, (Et.sub.2)Arg, Abu, Ala, Gly, His, Lys, or an .alpha.-R' substituted derivative thereof, Dtc, Tpr and Pro;B is a D- or L-amino acid chosen from Arg, HArg, NArg, (Me.sub.2)Arg, (Et.sub.2)Arg and Lys or an .alpha.-R' substituted derivative thereof;Q is absent or a D or L amino acid chosen from Tyr, (Alk)Tyr, Phe, (4'W)Phe, HPhe, Phg, Pro, Trp, His, Ser, (Alk)Ser, Thr, (Alk)Thr, (Alk)Cys, (Alk)Pen, Ala, Val, Nva, Met, Leu, Ile, Nle and Nal, or an .alpha.-R' substituted derivative thereof;M is absent or Gly or a D- or L-amino acid chosen from Glu, Phe, Pro, Lys and Ser or, provided n is 1, B-Gly-Glu-Q;W is halogen or Alk;R' is Alk or PhCH.sub.2 ; ##STR2## wherein Z.sub.1 and Z.sub.2 are linked via a covalent bond between L.sup.1 and L.sup.2 ; or Z.sub.1 and Z.sub.
    Type: Grant
    Filed: August 26, 1994
    Date of Patent: July 1, 1997
    Assignee: SmithKline Beecham Corporation
    Inventors: Fadia El-Fehail Ali, James Martin Samanen