Abstract: The present invention relates to compounds that target monocytes, macrophages and other cells (such as dendritic cells) that express CD-206, particularly those cells at are assembled at a site of disease, using a target moiety coupled to a glucan backbone. The compounds disclosed here preferably comprise a glucan backbone, a targeting moiety, a targeting moiety linker, a payload and optionally a payload linker. The present invention also provides methods of making such compounds and compositions. The present invention also provides diagnostic methods and methods of treatment using compounds comprising a target moiety coupled to a glucan backbone.