Patents by Inventor Faith M. Uckun
Faith M. Uckun has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7071176Abstract: Aryl phosphate derivatives of d4T with para-bromo substitution on the aryl group show markedly increased potency as anti-HIV agents without undesirable levels of cytotoxic activity. In particular, these derivatives are potent inhibitors of HIV reverse transcriptase. In a preferred aspect of the present invention, the phosphorus of the aryl phosphate group is further substituted with an amino acid residue that may be esterified or substituted, such as a methoxy alaninyl group.Type: GrantFiled: December 1, 2003Date of Patent: July 4, 2006Assignee: Parker Hughes InstituteInventors: Faith M. Uckun, Rakesh Vig
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Patent number: 7064114Abstract: A pharmaceutical composition adapted for use as a spermicide, the composition comprising a gel-microemulsion comprising an oil-in-water microemulsion and a polymeric hydrogel. The gel-microemulsion can be used in a spermicidal method. Also, a gel-microemulsion pharmaceutical composition adapted for use as a formulation base for additional therapeutic agents. Examples of additional agents include, anti-microbial agents and spermicidal agents. Such gel-microemulsions with additional therapeutic agents can be used in methods for appropriate therapeutic treatment. Also, a gel-microemulsion pharmaceutical composition that is adapted for use as both a spermicide and formulation base for anti-microbial agents to provide a dual function contraceptive/anti-microbial formulation. Method of using such a composition as a dual function contraceptive/anti-microbial formulation are also included.Type: GrantFiled: September 19, 2001Date of Patent: June 20, 2006Assignee: Parker Hughes InstituteInventors: Seang Yiv, Mingshu Li, Osmond D'Cruz, Faith M. Uckun
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Patent number: 6960606Abstract: Novel aromatic and heterocyclic thiazolyl thiourea compounds, pharameutical compositions including such, and methods for their use are disclosed. The compounds are effective agents for the treatment of HIV infection, including non-nucleoside inhibitor-resistant, and multi-drug resistant strains of HIV.Type: GrantFiled: April 15, 2003Date of Patent: November 1, 2005Assignee: Parker Hughes InstituteInventors: Faith M. Uckun, Taracad K. Venkatachalam
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Publication number: 20040235815Abstract: The invention provides methods for treating cancer and compounds that are useful for the treatment of tumors, as well as pharmaceutical compositions comprising the compounds, and synthetic methods and intermediates useful for preparing the compounds.Type: ApplicationFiled: May 28, 2004Publication date: November 25, 2004Applicant: Parker Hughes InstituteInventors: Faith M. Uckun, Yanhong Dong, Phalguni Gosh
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Patent number: 6737537Abstract: The present invention describes platinum (II) compounds and compositions useful for treating a subject with a tumor and/or inducing apoptosis in a population of cells. The present invention also describes pharmaceutical compositions containing the aforementioned inventive compound(s) in combination with a pharmaceutically acceptable carrier. Additionally, the invention further provides a method of inducing apoptosis in a population of cells and a method of treating a subject with a tumor, wherein the method comprises administering to the subject a therapeutically effective amount of the aforementioned compound(s) or composition(s).Type: GrantFiled: May 15, 2002Date of Patent: May 18, 2004Assignee: Parker Hughes InstituteInventors: Faith M. Uckun, Rama K. Narla
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Patent number: 6667339Abstract: Vanadium (IV) complexes containing a substituted or unsubstituted catecholate ligand, and the spermicidal activity of such compounds. Preferred compounds are vanadocene (IV) complexes containing alkyl substituted catecholate ligands.Type: GrantFiled: July 23, 2002Date of Patent: December 23, 2003Assignee: Parker Hughes InstituteInventors: Phalguni Ghosh, Faith M. Uckun, Osmond D′Cruz
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Patent number: 6642221Abstract: Vanadium compounds as anti-proliferative agents. These compounds act to disrupt mitotic and meiotic spindle formation and thus are useful to prevent cell mitosis (proliferation) and meiosis.Type: GrantFiled: November 15, 2000Date of Patent: November 4, 2003Assignee: Parker Hughes InstituteInventors: Faith M Uckun, Christopher S Navara
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Patent number: 6635651Abstract: The present invention describes a therapeutic method useful for treating or preventing a condition of platelet aggregation in a subject including administering a pharmaceutically effective amount of a compound or composition that inhibits JAK-3 and/or tyrosine phosphorylation of STAT-3 and inhibits thrombin induced platelet aggregation. The condition of platelet aggregation includes hematopoietic and cerbrovascular diseases.Type: GrantFiled: May 28, 2002Date of Patent: October 21, 2003Assignee: Parker Hughes InstituteInventor: Faith M. Uckun
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Patent number: 6482816Abstract: Novel organic arsenic compounds are described as cytotoxic agents with potent anti-tumor activity against cancer cells and particularly, with regard to human leukemic cells and breast cancer cells.Type: GrantFiled: November 27, 2000Date of Patent: November 19, 2002Assignee: Parker Hughes InstituteInventors: Faith M. Uckun, Xing-Ping Liu
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Patent number: 6407078Abstract: Contraceptive activity as well as anti-viral protection can be provided by contraceptive compositions containing a pyrimidine-based nucleoside or nucleotide exhibiting spermicidal or sperm-immobilizing activity. In one example, the active ingredient contains a thymine ring (e.g. AZT) that has 5-halo, 6-alkoxy substitution. Additional improvements in anti-HIV activity for certain AZT derivatives are seen by providing the pentose ring of AZT with aryl phosphate substitution.Type: GrantFiled: February 3, 2000Date of Patent: June 18, 2002Assignee: Parker Hughes InstituteInventors: Osmond D'Cruz, Faith M. Uckun, Taracad Venkatachalam
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Patent number: 6362228Abstract: Novel phenylethyl-thiourea (PHET) compounds as inhibitors of reverse transcriptase and effective agents for the treatment of HIV infection, including mutant, drug-sensitive, drug-resistant, and multi-drug resistant strains of HIV.Type: GrantFiled: December 20, 2000Date of Patent: March 26, 2002Assignee: Parker Hughes InstituteInventors: Faith M. Uckun, Taracad K. Ventatachalam
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Patent number: 6350736Abstract: Aryl phosphate derivatives of d4T with para-bromo substitution on the aryl group show markedly increased potency as anti-HIV agents without undesirable levels of cytotoxic activity. In particular, these derivatives are potent inhibitors of HIV reverse transcriptase. In a preferred aspect of the present invention, the phosphorus of the aryl phosphate group is further substituted with an amino acid residue that may be esterified or substituted, such as a methoxy alaninyl group.Type: GrantFiled: December 15, 1999Date of Patent: February 26, 2002Assignee: Parker Hughes InstituteInventors: Faith M. Uckun, Rakesh Vig
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Patent number: 6337348Abstract: Organometallic oxovanadium (IV) complexes having potent spermicidal activity, particularly those having at least one bidentate ligand. Preferred compounds are stable oxovanadium (IV) complexes having, as ancillary ligands linked via nitrogen or oxygen-metal bonds, bis and/or mono-1,10-phenanthroline; 2,2′-bipyridyl; or 2-hydroxyacetophenone.Type: GrantFiled: February 16, 2000Date of Patent: January 8, 2002Assignee: Parker Hughes InstituteInventors: Faith M. Uckun, Osmond D'Cruz, Wanhong Dong
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Patent number: 6334998Abstract: A method for preventing and treating ALS by administering a phytoestrogen, preferably genistein.Type: GrantFiled: December 7, 1999Date of Patent: January 1, 2002Assignee: Parker Hughes InstituteInventors: Faith M. Uckun, Vuoung N. Trieu, Xing-Ping Liu
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Patent number: 6335364Abstract: Novel tubulin binding compounds (SPIKETS) having potent tubulin depolymerization activity and inhibitory activity against tubulin polymerization. The compounds are effective agents for inhibiting cellular proliferation, for example, in cancer cells. The compounds are adapted to interact favorably with a novel SP binding pocket on tubulin, which pocket is useful for screening of anti-tubulin, anti-proliferation, and anti-cancer drugs.Type: GrantFiled: June 29, 1999Date of Patent: January 1, 2002Assignee: Parker Hughes InstituteInventors: Faith M. Uckun, Chen Mao, He Huang
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Patent number: 6262053Abstract: Novel pharmaceutical compositions including melamine derivatives and methods for the treatment of cancer including prostate, brain, breast, and leukemia are described. The methods are directed to administering a therapeutically effective amount of a pharmaceutical composition including melamine derivatives having potent cytotoxic activity.Type: GrantFiled: June 23, 1999Date of Patent: July 17, 2001Assignee: Parker Hughes InstituteInventors: Faith M. Uckun, Xing-Ping Liu, Rama Narla
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Patent number: 6258820Abstract: Compounds of the formula: wherein: Ra is iodo, (C1-C4)hydroxyalkyl, benzyloxy, OCF3, SCF3, SO3H, SO2F, SO2NR2R3 where R2 is hydrogen or (C1-C4)alkyl and R3 is hydrogen, (C1-C4)alkyl, or phenyl, NR2R4 where R2 is hydrogen or (C1-C4)alkyl and R4 is phenyl; or a group of the formula wherein R5 and R6 are each independently, hydrogen, (C1-C4)alkyl, or (C1-C4) perfluoroalkyl, and R7 is hydrogen, halo, hydroxy, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)hydroxyalkyl, or N(R2)2, where R2 is hydrogen or (C1-C4)alkyl; n is an integer of 1-4; Rb is each, independently, hydrogen, halo, hydroxy, mercapto, (C1-C4)alkyl, (C1-C4)alkoxy, (C1-C4)thioalkyl, (C1-C4)hydroxyalkyl, nitro, cyano, methylenedioxy, ethylenedioxy, COCH3, CF3, OCF3, SCF3, COOH, SO3H, SO2F, phenyl, or phenyl substituted by a group selected from halo, hydroxy, mercapto, (C1-C4)alkyl, (C1-C4) alkoxy, (C1-C4)thioalkyl, (C1-C4)hydroxyalkyl, amino, nitro, cyano, CF3, COOH, SO3H, SO2NR2R3, SO2F where R2 is H or (C1-C4)alkyl andType: GrantFiled: July 20, 1999Date of Patent: July 10, 2001Assignee: Parker Hughes InstituteInventors: Faith M. Uckun, Xing-Ping Liu, Rama Krishna Narla
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Patent number: 6172071Abstract: A novel carbonyl-substituted quinazoline, preferably 4-(3′-bromobenzoyl)-6,7-dimethoxyquinazoline (WHI-P164), and methods for lowering blood cholesterol, including reducing total cholesterol and LDL-cholesterol levels by administration of the carbonyl quinazolines and compositions thereof.Type: GrantFiled: July 30, 1998Date of Patent: January 9, 2001Assignee: Hughes InstituteInventors: Faith M. Uckun, Vuong N. Trieu, Xing-Ping Liu
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Patent number: 5914410Abstract: Novel tetrahydrofuran-epoxide compounds are described as intermediates for the preparation of non-adjacent bis-THF-acetogenins of pharmaceutical interest. Also described is a novel stereocontrolled synthesis for preparing such intermediates starting with commercially available enantiomers of glycidyl benzylether.Type: GrantFiled: January 20, 1998Date of Patent: June 22, 1999Assignee: Wayne Hughes InstituteInventors: Keqiang Li, Faith M. Uckun