Patents by Inventor Fajun Nan

Fajun Nan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSITUTED CYCLIC COMPOUND, ITS PREPARATION PROCESS AND ITS MEDICAL USE
    Publication number: 20100168183
    Abstract: The present invention provides a substituted cyclic compound of the following general formula I or II: its preparation process and its use as a glucagon-like peptide-1 receptor regulator for preventing or treating metabolic disorders including, but not limited to, diabetes, insulin resistance and obesity, etc.
    Type: Application
    Filed: June 21, 2006
    Publication date: July 1, 2010
    Applicant: Shanghai Institute of Materia Medica, Chinese Academy of Science
    Inventors: Mingwei Wang, Na Li, Xin Xie, Qing Liu, Caihong Zhou, Fajun Nan
  • Bisheterocycle tandem compounds useful as antiviral agents, the uses thereof and the compositions comprising such compounds
    Patent number: 7741348
    Abstract: The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.
    Type: Grant
    Filed: January 24, 2006
    Date of Patent: June 22, 2010
    Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Fajun Nan, Jianping Zuo, Wenlong Wang, Guifeng Wang, Haijun Chen, Peilan He
  • Isoquinoline-1,3,4-trione compounds, the synthetic method and the use thereof
    Patent number: 7683073
    Abstract: The invention relates to various substituted isoquinoline-1,3,4-trione, the synthetic method thereof and the use for treating neurodegenerative diseases, especially as the medicine for Alzheimer's disease, apoplexy and brain ischemic injuries.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: March 23, 2010
    Assignee: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Fajun Nan, Jia Li, Yihua Chen, Yahui Zhang, Min Gu, Huajie Zhang
  • Heterocyclic Non-Nucleoside Compounds, Their Preparation, Pharmaceutical Composition And Their Use As Antiviral Agents
    Publication number: 20100056569
    Abstract: The invention relates a kind of antiviral agents, more concretely, relates to a kind of heterocyclic non-nucleoside compounds with the following structures, their preparation and pharmaceutical compositions including the compounds. The said compounds can be used as antiviral agents and as medicaments for treating diseases such as hepatitis B, influenza, herpes, HIV and so on.
    Type: Application
    Filed: June 13, 2007
    Publication date: March 4, 2010
    Applicant: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Fajun Nan, Jianping Zuo, Haijun Chen, Guifeng Wang, Min Gu, Fenghua Zhu, Wei Tang
  • Bisheterocycle Tandem Compounds Useful as Antiviral Agents, the Uses Thereof and the Compositions Comprising Such Compounds
    Publication number: 20080306121
    Abstract: The present invention provides small molecule compounds of bisheterocycle in tandem having the structural formula of P1-P2, and the use thereof as well as a composition containing the compounds, each of P1 and P2 is an unsaturated 5-member heterocyclic ring having one or two heteroatoms. This compound may effectively inhibit the replication of influenza virus, the DNA replication of hepatitis B virus (HBV), and the formation of HBsAg and HBeAg. These compounds can be used for the preparation of a medicament for viral diseases, and may overcome the limitations of the known nucleosides drugs, including cytotoxicity, the requirement of other drugs having different structures for against the drug-resistant virus variants induced by long-term therapy. The structure of the compounds according to the invention is relatively simple and easy to be prepared.
    Type: Application
    Filed: January 24, 2006
    Publication date: December 11, 2008
    Applicant: Shanghai Institute of Materia Medica, Chinese Academy of Sciences
    Inventors: Fajun Nan, Jianping Zuo, Wenlong Wang, Haijun Chen, Peilan He
  • LIGANDS FOR METABOTROPIC GLUTAMATE RECEPTORS AND INHIBITORS OF NAALADASE
    Publication number: 20080176821
    Abstract: The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.
    Type: Application
    Filed: February 11, 2008
    Publication date: July 24, 2008
    Inventors: Alan P. Kozikowski, Jarda T. Wroblewski, Fajun Nan
  • Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
    Patent number: 7381745
    Abstract: The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.
    Type: Grant
    Filed: February 25, 2003
    Date of Patent: June 3, 2008
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Jarda T. Wroblewski, Fajun Nan
  • Glucagon-like peptide-1 receptor agonists, the preparation and the use of the same
    Publication number: 20070043093
    Abstract: The present invention provides the glucagon-like peptide-1 receptor agonists. It is indicated that the agonists have good binding capability to glucagon-like peptide-1 receptor by pharmacological tests. The present invention also provides the preparation of the agonists.
    Type: Application
    Filed: December 25, 2003
    Publication date: February 22, 2007
    Inventors: Fajun Nan, Mingwei Wang, Wenlong Wang, Caihong Zhou
  • Isoquinoline-1,3,4-trione compounds, the synthetic method and the use thereof
    Publication number: 20060135557
    Abstract: The invention relates to various substituted isoquinoline-1,3,4-trione, the synthetic method thereof and the use for treating neurodegenerative diseases, especially as the medicine for Alzheimer's disease, apoplexy and brain ischemic injuries.
    Type: Application
    Filed: December 13, 2005
    Publication date: June 22, 2006
    Inventors: Fajun Nan, Jia Li, Yihua Chen, Yahui Zhang, Min Gu, Huajie Zhang
  • Methionine aminopeptidase inhibitor
    Publication number: 20050113420
    Abstract: The invention provides a new methionine aminopeptidase inhibitors with the following formula (I), wherein R1, R2, R3, R4, R5, R6 and X have the meanings given in the description. Pharmacological experiment shows that they display good inhibition activity for methionine aminopeptidase.
    Type: Application
    Filed: March 25, 2003
    Publication date: May 26, 2005
    Inventors: Fajun Nan, Qizhuang Ye, Jingya Li, Zhiying Liu, Qunli Luo, Yongmei Cui
  • Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
    Publication number: 20040002478
    Abstract: The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.
    Type: Application
    Filed: February 25, 2003
    Publication date: January 1, 2004
    Inventors: Alan P. Kozikowski, Jarda T. Wroblewski, Fajun Nan
  • Ligands for metabotropic glutamate receptors and inhibitors of NAALADase
    Patent number: 6528499
    Abstract: The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.
    Type: Grant
    Filed: September 15, 2000
    Date of Patent: March 4, 2003
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Jarda T. Wroblewski, Fajun Nan
  • Ligands for metabotropic glutamate receptors and inhibitors of NAALAdase
    Patent number: 6479470
    Abstract: The present invention relates to novel compounds and formulations thereof which compounds are ligands, e.g., agonists or antagonists, for a metabotropic glutamate receptor or a NAALADase enzyme or both. The present invention also relates to methods of modulating the activity of a metabotropic glutamate receptor or a NAALADase enzyme or both, e.g., in a subject in need thereof, using a compound or formulation of the present invention. The present invention also relates to methods of treating a subject suffering from a chronic or acute disease, malady or condition due at least in part to an abnormality in the activity of an endogenous metabotropic glutamate receptor or a NAALADase enzyme or both, using a compound or formulation of the present invention.
    Type: Grant
    Filed: April 27, 2000
    Date of Patent: November 12, 2002
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Jarda T. Wroblewski, Fajun Nan