Publication number: 20190352297
Abstract: The invention relates to a compound wherein R1 is selected from —I, —Br, —Cl, —F, C1-C6-alkyl, —O(CH2)mCH3, —(CH2)mOCH3, C1-C6-haloalkyl, a cycloalkyl, a heterocycle, a aryl or heteroaryl, wherein R2 is selected from H, C1-C6-alkyl, C1-C6-haloalkyl, C3-C6-cycloalkyl, —CH2—(C3-C6-cycloalkyl), or —(CH2)rOCH3, wherein R3 is —NH2, —NH—R4, —NHC(?O)—R4, —NHC(?O)NH—R4, —NHC(?S)—R4 or —NHC(?S)NH—R4, wherein R4 is selected from a cycloalkyl, a heterocycle, a aryl or a heteroaryl, or -L-R5, wherein L is selected from C1-C5-alkyl, a cycloalkyl, a heterocycle, a aryl, or a heteroaryl, and R5 is selected from —OH, —CH2OH, —NH2, —COOH, —CONH2, —CONH—R6 or carboxylic acid isosteres, wherein R6 is selected from C1-C4-alkyl, with n, m and r being 0, 1, 2, 3, 4 or 5 and their use.
Type:
Application
Filed:
January 6, 2017
Publication date:
November 21, 2019
Applicant:
UNIVERSITAT BERN
Inventors:
Jean-Louis REYMOND, Falco KILCHMANN