Patents by Inventor Fan Fan HOU

Fan Fan HOU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Use of an urushiol compound in preparation of pharmaceutical compositions for inhibiting Smad3 phosphorylation
    Patent number: 9139502
    Abstract: The invention relates to a use of an urushiol compound (code named GQ-5) in preparation of pharmaceutical compositions for inhibiting Smad3 phosphorylation. We verify that GQ-5 inhibited the interaction of Smad3 with TGF-? type I receptor (T?RI), inhibited subsequent phosphorylation of Smad3, reduced nuclear translocation of Smads complex, and suppressed the transcription of major fibrotic genes such as ?-smooth muscle actin (?-SMA), collagen I and fibronectin. Therefore, GQ-5 could be a potent and selective inhibitor of TGF-?1-induced Smad3 phosphorylation, and be used to prepare pharmaceutical compositions for inhibiting Smad3 phosphorylation.
    Type: Grant
    Filed: November 3, 2014
    Date of Patent: September 22, 2015
    Assignees: SOUTHERN HOSPITAL, SOUTHERN MEDICAL UNIVERSITY, KUNMING INSTITUTE OF BOTANY, CHINESE ACADEMY OF SCIENCES
    Inventors: Fan Fan Hou, Yongxian Cheng, Jing Nie, Jun Al, Jiangbo He
  • USE OF AN URUSHIOL COMPOUND IN PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR INHIBITING SMAD3 PHOSPHORYLATION
    Publication number: 20150175511
    Abstract: The invention relates to a use of an urushiol compound (code named GQ-5) in preparation of pharmaceutical compositions for inhibiting Smad3 phosphorylation. We verify that GQ-5 inhibited the interaction of Smad3 with TGF-? type I receptor (T?RI), inhibited subsequent phosphorylation of Smad3, reduced nuclear translocation of Smads complex, and suppressed the transcription of major fibrotic genes such as ?-smooth muscle actin (?-SMA), collagen I and fibronectin. Therefore, GQ-5 could be a potent and selective inhibitor of TGF-?1-induced Smad3 phosphorylation, and be used to prepare pharmaceutical compositions for inhibiting Smad3 phosphorylation.
    Type: Application
    Filed: November 3, 2014
    Publication date: June 25, 2015
    Applicants: SOUTHERN HOSPITAL, SOUTHERN MEDICAL UNIVERSITY, Kunming Institute of Botany, Chinese Academy of Sciences
    Inventors: Fan Fan HOU, Yongxian CHENG, Jing NIE, Jun AI, Jiangbo HE