Abstract: An oral care implement having a head with a bristle bearing surface. The oral care implement may include a central bristle tuft extending from a central portion of the bristle bearing surface, the central bristle tuft terminating in a domed distal surface. Furthermore, the oral care implement may include a plurality of perimetric bristle tufts extending from the bristle bearing surface and arranged to circumferentially surround the central bristle tuft. Each of the perimetric bristle tufts may have an inclined distal surface that slopes downward towards the central bristle tuft. The bristle bearing surface of the head may have a total surface area (TSA), and the toothbrush may include a tooth cleaning element field having X number of tooth cleaning elements that collectively occupy a total cleaning element area (TCEA) such that 1 X × T ? C ? E ? A T ? S ? A = Z and Z is in a range of 0.04 to 0.065.

Abstract: The present disclosure discloses an automatic leveling control method for a four-leg support working platform, which comprises the steps: determining the mass center position of the working platform, determining the main bearing quadrant and distinguishing active legs from the driven leg; adjusting the driven leg to weak state, controlling all legs to synchronously actuate for leveling; calculating the limit compensating actuation length of the driven leg, and performing compensating actuation until accomplishing the leveling process. The method is advantageous in: high speed, high robustness, no repeated oscillation. The mass center always stays within the bearing zone of the active legs, thus completely eliminating capsizing risk of the working platform. The compensating actuation of the driven leg ensures there is no weak leg, and hence high attitude and load-bearing stability of the working platform is achieved.

Abstract: The present disclosure discloses a leveling control method for a multi-point support platform, which comprises the steps: respectively measuring and obtaining a load-bearing interaction matrix and a deformation interaction matrix of the platform to construct a load-bearing and deformation joint control matrix; calculating the optimal loads of the legs and measuring the current loads of the legs to obtain the load deviation rates of the legs, and determining if the platform warrants leveling in combination with the two-dimensional inclination angles of the platform; constructing a platform geometry and leg load joint control equation according to the two-dimensional inclination angles of the platform, the load deviations of the legs and the load-bearing and deformation joint control matrix, calculating the actuation quantities of the legs and performing synchronous leveling; and determining the load deviation rates of the legs and the two-dimensional inclination angles of the platform cyclically and performing

Abstract: An oral care implement having a head with a plurality of cleaning elements coupled thereto and extending therefrom. In the exemplified embodiment, the cleaning elements have a plurality of bristle tufts each including a plurality of bristle filaments. In one aspect, the oral care implement may include a first bristle tuft having inner and outer filaments with the outer filaments being taller than the inner filaments and a second bristle tuft having inner and outer filaments with the outer filaments being shorter than the inner filaments. The first bristle tufts may be arranged on the head in a position so as to surround the second bristle tufts, or the second bristle tufts may be arranged on the head in a position so as to surround the first bristle tufts. Distal ends of the first and second bristle tufts may be angled.

Abstract: A method of screening for a drug combination for treating colorectal carcinoma, the screened drug combination and its related application are provided. The drug combination includes at least three selected from Regorafenib, Gemcitabine, Cetuximab and 5-Fluorouracil. With the method of the disclosure, the best and novel drug combination can be selected from the existing clinical drugs, the technical effect of rapidly screening for a drug combination can be achieved, and the screened combination drug has an excellent therapeutic effect.

Abstract: In an embodiment, a chip is used for isolating RBC from a whole blood and includes an accommodating space, a porous membrane and a microchannel system. The accommodating space is configured for containing a whole blood sample including RBC debris. The porous membrane is disposed at a bottom of the accommodating space and includes a plurality of pores. A diameter of the pores is larger than a size of the RBC debris and larger than a mean diameter of WBCs and CTCs. The microchannel system includes a liquid inlet, a liquid outlet and a microchannel. The microchannel is disposed between and communicates with the liquid inlet and the liquid outlet. The microchannel is disposed under the porous membrane.

Abstract: Provided are a cell identification method for identifying target cells by combining the results of fluorescence intensity analysis, fluorescence image analysis, and white light image analysis.